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While Whole Slide Imaging (WSI) scanners remain the gold standard for digitizing pathology samples, their high cost limits accessibility in many healthcare settings. Other low-cost solutions also face critical limitations: automated…

Computer Vision and Pattern Recognition · Computer Science 2025-10-08 Yousef Yeganeh , Maximilian Frantzen , Michael Lee , Kun-Hsing Yu , Nassir Navab , Azade Farshad

High-throughput 2D and 3D scanning electron microscopy, which relies on automation and dependable control algorithms, requires high image quality with minimal human intervention. Classical focus and astigmatism correction algorithms attempt…

Instrumentation and Detectors · Physics 2023-05-10 Philipp Johannes Schubert , Rangoli Saxena , Joergen Kornfeld

Synthetic aperture sonar (SAS) requires precise positional and environmental information to produce well-focused output during the image reconstruction step. However, errors in these measurements are commonly present resulting in defocused…

Image and Video Processing · Electrical Eng. & Systems 2021-08-02 Isaac Gerg , Vishal Monga

Synthetic aperture sonar (SAS) requires precise time-of-flight measurements of the transmitted/received waveform to produce well-focused imagery. It is not uncommon for errors in these measurements to be present resulting in image…

Computer Vision and Pattern Recognition · Computer Science 2021-06-02 Isaac D. Gerg , Vishal Monga

We demonstrate a deep learning-based offline autofocusing method, termed Deep-R, that is trained to rapidly and blindly autofocus a single-shot microscopy image of a specimen that is acquired at an arbitrary out-of-focus plane. We…

Image and Video Processing · Electrical Eng. & Systems 2021-01-25 Yilin Luo , Luzhe Huang , Yair Rivenson , Aydogan Ozcan

We demonstrate that deep learning methods can determine the best focus position from 1-2 image samples, enabling 5-10x faster focus than traditional search-based methods. In contrast with phase detection methods, deep autofocus does not…

Image and Video Processing · Electrical Eng. & Systems 2020-03-02 Chengyu Wang , Qian Huang , Ming Cheng , Zhan Ma , David J. Brady

Many microscopy applications are limited by the total amount of usable light and are consequently challenged by the resulting levels of noise in the acquired images. This problem is often addressed via (supervised) deep learning based…

Image and Video Processing · Electrical Eng. & Systems 2020-08-20 Anna S. Goncharova , Alf Honigmann , Florian Jug , Alexander Krull

This paper presents a novel keypoints-based attention mechanism for visual recognition in still images. Deep Convolutional Neural Networks (CNNs) for recognizing images with distinctive classes have shown great success, but their…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Asish Bera , Zachary Wharton , Yonghuai Liu , Nik Bessis , Ardhendu Behera

Autofocus is necessary for high-throughput and real-time scanning in microscopic imaging. Traditional methods rely on complex hardware or iterative hill-climbing algorithms. Recent learning-based approaches have demonstrated remarkable…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Yongping Zhai , Xiaoxi Fu , Qiang Su , Jia Hu , Yake Zhang , Yunfeng Zhou , Chaofan Zhang , Xiao Li , Wenxin Wang , Dongdong Wu , Shen Yan

We propose a learning-based depth from focus/defocus (DFF), which takes a focal stack as input for estimating scene depth. Defocus blur is a useful cue for depth estimation. However, the size of the blur depends on not only scene depth but…

Computer Vision and Pattern Recognition · Computer Science 2022-03-01 Yuki Fujimura , Masaaki Iiyama , Takuya Funatomi , Yasuhiro Mukaigawa

This paper describes AutoFocus, an efficient multi-scale inference algorithm for deep-learning based object detectors. Instead of processing an entire image pyramid, AutoFocus adopts a coarse to fine approach and only processes regions…

Computer Vision and Pattern Recognition · Computer Science 2019-08-02 Mahyar Najibi , Bharat Singh , Larry S. Davis

In this work, we propose a novel unsupervised deep learning model to address multi-focus image fusion problem. First, we train an encoder-decoder network in unsupervised manner to acquire deep feature of input images. And then we utilize…

Computer Vision and Pattern Recognition · Computer Science 2020-09-25 Boyuan Ma , Xiaojuan Ban , Haiyou Huang , Yu Zhu

Real world images often have highly imbalanced content density. Some areas are very uniform, e.g., large patches of blue sky, while other areas are scattered with many small objects. Yet, the commonly used successive grid downsampling…

Computer Vision and Pattern Recognition · Computer Science 2023-10-27 Chen Ziwen , Kaushik Patnaik , Shuangfei Zhai , Alvin Wan , Zhile Ren , Alex Schwing , Alex Colburn , Li Fuxin

Automation in optical microscopy is critical for enabling high-throughput imaging across a wide range of biomedical applications. Among the essential components of automated systems, robust autofocusing plays a pivotal role in maintaining…

Autofocus is an important task for digital cameras, yet current approaches often exhibit poor performance. We propose a learning-based approach to this problem, and provide a realistic dataset of sufficient size for effective learning. Our…

Computer Vision and Pattern Recognition · Computer Science 2020-05-05 Charles Herrmann , Richard Strong Bowen , Neal Wadhwa , Rahul Garg , Qiurui He , Jonathan T. Barron , Ramin Zabih

Fluorescence microscopy plays an important role in biomedical research. The depth-variant point spread function (PSF) of a fluorescence microscope produces low-quality images especially in the out-of-focus regions of thick specimens.…

Image and Video Processing · Electrical Eng. & Systems 2019-07-09 Da He , De Cai , Jiasheng Zhou , Jiajia Luo , Sung-Liang Chen

Optical microscopy is an essential tool in biology and medicine. Imaging thin, yet non-flat objects in a single shot (without relying on more sophisticated sectioning setups) remains challenging as the shallow depth of field that comes with…

Image and Video Processing · Electrical Eng. & Systems 2020-10-14 Adrian Shajkofci , Michael Liebling

In contemporary imaging systems, achieving optimal auto-focus (AF) performance hinges on precise lens positioning. Extensive research has delved into refining algorithms for determining the ideal lens position across passive, active, and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-03 Ali Karaoglu

Depth-from-focus (DFF) is a technique that infers depth using the focus change of a camera. In this work, we propose a convolutional neural network (CNN) to find the best-focused pixels in a focal stack and infer depth from the focus…

Computer Vision and Pattern Recognition · Computer Science 2022-03-21 Fengting Yang , Xiaolei Huang , Zihan Zhou

Image Phase Alignment Super-Sampling (ImPASS) is a computational imaging algorithm for converting a sequence of displaced low-resolution images into a single high-resolution image. The method consists of a unique combination of Phase…

Optics · Physics 2025-09-01 James N. Caron
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