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In many tasks, in particular in natural science, the goal is to determine hidden system parameters from a set of measurements. Often, the forward process from parameter- to measurement-space is a well-defined function, whereas the inverse…

Graphical models are widely used to study complex multivariate biological systems. Network inference algorithms aim to reverse-engineer such models from noisy experimental data. It is common to assess such algorithms using techniques from…

Methodology · Statistics 2014-03-03 Chris J. Oates , Richard Amos , Simon E. F. Spencer

Resource allocation and transceivers in wireless networks are usually designed by solving optimization problems subject to specific constraints, which can be formulated as variable or functional optimization. If the objective and constraint…

Machine Learning · Computer Science 2020-01-06 Dong Liu , Chengjian Sun , Chenyang Yang , Lajos Hanzo

A major challenge in machine learning is resilience to out-of-distribution data, that is data that exists outside of the distribution of a model's training data. Training is often performed using limited, carefully curated datasets and so…

Computer Vision and Pattern Recognition · Computer Science 2022-11-30 Christopher J. Holder , Majid Khonji , Jorge Dias , Muhammad Shafique

The exploration of complex physical or technological processes usually requires exploiting available information from different sources: (i) physical laws often represented as a family of parameter dependent partial differential equations…

Numerical Analysis · Mathematics 2020-02-04 Albert Cohen , Wolfgang Dahmen , Ron DeVore

Solving inverse problems, such as parameter estimation and optimal control, is a vital part of science. Many experiments repeatedly collect data and rely on machine learning algorithms to quickly infer solutions to the associated inverse…

Machine Learning · Computer Science 2022-10-14 Philipp Holl , Vladlen Koltun , Nils Thuerey

We consider the problem of inferring the values of an arbitrary set of variables (e.g., risk of diseases) given other observed variables (e.g., symptoms and diagnosed diseases) and high-dimensional signals (e.g., MRI images or EEG). This is…

Machine Learning · Statistics 2019-02-07 Hao Wang , Chengzhi Mao , Hao He , Mingmin Zhao , Tommi S. Jaakkola , Dina Katabi

In this work we consider data-driven optimization problems where one must maximize a function given only queries at a fixed set of points. This problem setting emerges in many domains where function evaluation is a complex and expensive…

Machine Learning · Computer Science 2021-02-17 Justin Fu , Sergey Levine

Score-based diffusion models achieve state-of-the-art performance for inverse problems, but their practical deployment is hindered by long inference times and cumbersome hyperparameter tuning. While pretrained diffusion models can be reused…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Julio Oscanoa , Irmak Sivgin , Cagan Alkan , Daniel Ennis , John Pauly , Mert Pilanci , Shreyas Vasanawala

Deep neural networks have become a foundational tool for addressing imaging inverse problems. They are typically trained for a specific task, with a supervised loss to learn a mapping from the observations to the image to recover. However,…

Computer Vision and Pattern Recognition · Computer Science 2023-12-01 Matthieu Terris , Thomas Moreau

Parameter estimation for differential equations from measured data is an inverse problem prevalent across quantitative sciences. Physics-Informed Neural Networks (PINNs) have emerged as effective tools for solving such problems, especially…

Machine Learning · Computer Science 2025-04-08 Marius Almanstötter , Roman Vetter , Dagmar Iber

Learning-to-optimize is an emerging framework that seeks to speed up the solution of certain optimization problems by leveraging training data. Learned optimization solvers have been shown to outperform classical optimization algorithms in…

Optimization and Control · Mathematics 2023-02-27 Hong Ye Tan , Subhadip Mukherjee , Junqi Tang , Carola-Bibiane Schönlieb

Parameter estimation remains a challenging task across many areas of engineering. Because data acquisition can often be costly, limited, or prone to inaccuracies (noise, uncertainty) it is crucial to identify sensor configurations that…

Machine Learning · Statistics 2025-11-20 Georgios Venianakis , Constantinos Theodoropoulos , Michail Kavousanakis

Maximum inner product search (MIPS) is a crucial subroutine in machine learning, requiring the identification of key vectors that align best with a given query. We propose amortized MIPS: a learning-based approach that trains neural…

Machine Learning · Computer Science 2026-03-10 Theo X. Olausson , João Monteiro , Michal Klein , Marco Cuturi

Machine learning methods for computational imaging require uncertainty estimation to be reliable in real settings. While Bayesian models offer a computationally tractable way of recovering uncertainty, they need large data volumes to be…

Machine Learning · Computer Science 2020-08-24 Francesco Tonolini , Jack Radford , Alex Turpin , Daniele Faccio , Roderick Murray-Smith

Inverse problems are pervasive mathematical methods in inferring knowledge from observational and experimental data by leveraging simulations and models. Unlike direct inference methods, inverse problem approaches typically require many…

Computational Physics · Physics 2019-12-20 Sheroze Sheriffdeen , Jean C. Ragusa , Jim E. Morel , Marvin L. Adams , Tan Bui-Thanh

Many physical and engineering systems require solving direct problems to predict behavior and inverse problems to determine unknown parameters from measurement. In this work, we study both aspects for systems governed by differential…

Numerical Analysis · Mathematics 2026-03-04 Noura Al Helwani , Sophie Moufawad , Georges Sakr

Physics-informed neural networks (PINNs) have proven a suitable mathematical scaffold for solving inverse ordinary (ODE) and partial differential equations (PDE). Typical inverse PINNs are formulated as soft-constrained multi-objective…

Machine Learning · Computer Science 2023-04-17 Gabriel S. Gusmão , Andrew J. Medford

Across scientific domains, a fundamental challenge is to characterize and compute the mappings from underlying physical processes to observed signals and measurements. While nonlinear neural networks have achieved considerable success, they…

Machine Learning · Computer Science 2025-08-11 Alexander DeLise , Kyle Loh , Krish Patel , Meredith Teague , Andrea Arnold , Matthias Chung

Optimization in machine learning typically deals with the minimization of empirical objectives defined by training data. However, the ultimate goal of learning is to minimize the error on future data (test error), for which the training…

Machine Learning · Statistics 2021-11-08 Bernhard Stankewitz , Nicole Mücke , Lorenzo Rosasco