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This study proposes MCEMOL (Multi-Constrained Evolutionary Molecular Design Framework), a molecular optimization approach integrating rule-based evolution with molecular crossover. MCEMOL employs dual-layer evolution: optimizing…

Neural and Evolutionary Computing · Computer Science 2026-01-16 Shanxian Lin , Wei Xia , Yuichi Nagata , Haichuan Yang

Molecular evolution is the process of simulating the natural evolution of molecules in chemical space to explore potential molecular structures and properties. The relationships between similar molecules are often described through…

Biomolecules · Quantitative Biology 2025-01-28 Kun Li , Longtao Hu , Xiantao Cai , Jia Wu , Wenbin Hu

A methodology is introduced which uses three simple objective function features to predict effective control parameters for differential evolution. This is achieved using cluster analysis techniques to classify objective functions using…

Neural and Evolutionary Computing · Computer Science 2019-06-25 Sean P. Walton , M. Rowan Brown

Open-pit mine scheduling is a complex real world optimization problem that involves uncertain economic values and dynamically changing resource capacities. Evolutionary algorithms are particularly effective in these scenarios, as they can…

Neural and Evolutionary Computing · Computer Science 2026-04-16 Ishara Hewa Pathiranage , Aneta Neumann

Evolution is the process of optimal adaptation of biological populations to their living environments. This is expressed via the concept of fitness, defined as relative reproductive success. However, it has been pointed out that this…

Populations and Evolution · Quantitative Biology 2025-04-17 Luís MA Bettencourt , Brandon J Grandison , Jordan T Kemp

Evolutionary algorithms (EAs) are population-based metaheuristics, originally inspired by aspects of natural evolution. Modern varieties incorporate a broad mixture of search mechanisms, and tend to blend inspiration from nature with…

Neural and Evolutionary Computing · Computer Science 2018-05-29 David W. Corne , Michael A. Lones

Real-valued genotypes together with the variation operators, mutation and crossover, constitute some of the fundamental building blocks of Evolutionary Algorithms. Real-valued genotypes are utilized in a broad range of contexts, from…

Neural and Evolutionary Computing · Computer Science 2020-05-20 Jørgen Nordmoen , Tønnes Frostad Nygaard , Eivind Samuelsen , Kyrre Glette

As artificial intelligence systems (AIs) become increasingly produced by recursive self-improvement, a form of evolution may emerge, with the traits of AI systems shaped by the success of earlier AIs in designing and propagating their…

Artificial Intelligence · Computer Science 2026-04-14 Kenneth D Harris

Ecological systems are emergent features of ecological and adaptive dynamics of a community of interacting species. By natural selection through the abiotic environment and by co-adaptation within the community, species evolve, thereby…

Populations and Evolution · Quantitative Biology 2018-07-03 Katharina Brinck , Henrik Jeldtoft Jensen

The range of applications of traditional optimization methods are limited by the features of the object variables, and of both the objective and the constraint functions. In contrast, population-based algorithms whose optimization…

Neural and Evolutionary Computing · Computer Science 2021-01-27 Mauro S. Innocente , Johann Sienz

Maintaining genetic diversity as a means to avoid premature convergence is critical in Genetic Programming. Several approaches have been proposed to achieve this, with some focusing on the mating phase from coupling dissimilar solutions to…

Neural and Evolutionary Computing · Computer Science 2023-03-31 José Maria Simões , Nuno Lourenço , Penousal Machado

At any moment in time, evolution is faced with a formidable challenge: refining the already highly optimised design of biological species, a feat accomplished through all preceding generations. In such a scenario, the impact of random…

Populations and Evolution · Quantitative Biology 2024-02-20 Alessandro Fontana , Marios Kyriazis

This paper presents a procedure to add broader diversity at the beginning of the evolutionary process. It consists of creating two initial populations with different parameter settings, evolving them for a small number of generations,…

Neural and Evolutionary Computing · Computer Science 2024-02-12 Antonio J. Tallón-Ballesteros , César Hervás-Martínez

Synthetic biology is an interdisciplinary field aiming to design biochemical systems with desired behaviors. To this end, molecular controllers have been developed which, when embedded into a pre-existing ambient biochemical network,…

Molecular Networks · Quantitative Biology 2019-08-29 Tomislav Plesa , Guy-Bart Stan , Thomas E. Ouldridge , Wooli Bae

The development of efficient and effective evolutionary multi-objective optimization (EMO) algorithms has been an active research topic in the evolutionary computation community. Over the years, many EMO algorithms have been proposed. The…

Neural and Evolutionary Computing · Computer Science 2020-08-18 Lie Meng Pang , Hisao Ishibuchi , Ke Shang

One of the outstanding challenges in comparative genomics is to interpret the evolutionary importance of regulatory variation between species. Rigorous molecular evolution-based methods to infer evidence for natural selection from…

Populations and Evolution · Quantitative Biology 2013-10-16 Joshua G. Schraiber , Yulia Mostovoy , Tiffany Y. Hsu , Rachel B. Brem

Despite great interest in techniques for stabilizing the dynamics of biological populations and metapopulations, very few practicable methods have been developed. We propose an easily implementable method, Adaptive Limiter Control (ALC),…

Populations and Evolution · Quantitative Biology 2012-12-27 Pratha Sah , Joseph Paul Salve , Sutirth Dey

The interaction networks of biological systems are known to take on several non-random structural properties, some of which are believed to positively influence system robustness. Researchers are only starting to understand how these…

Neural and Evolutionary Computing · Computer Science 2011-02-08 James M. Whitacre , Ruhul A. Sarker , Q. Tuan Pham

Designing controllers for complex industrial electronic systems is challenging due to nonlinearities and parameter uncertainties, and traditional methods are often slow and costly. To address this, we propose a novel autonomous design…

Systems and Control · Electrical Eng. & Systems 2025-07-23 Chenggang Cui , Jiaming Liu , Peifeng Hui , Pengfeng Lin , Chuanlin Zhang

Evolutionary algorithms, such as Differential Evolution, excel in solving real-parameter optimization challenges. However, the effectiveness of a single algorithm varies across different problem instances, necessitating considerable efforts…

Neural and Evolutionary Computing · Computer Science 2024-03-08 Hongshu Guo , Yining Ma , Zeyuan Ma , Jiacheng Chen , Xinglin Zhang , Zhiguang Cao , Jun Zhang , Yue-Jiao Gong