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In the social sciences we are often interested in comparing models specified by parametric equality or inequality constraints. For instance, when examining three group means $\{ \mu_1, \mu_2, \mu_3\}$ through an analysis of variance…

Methodology · Statistics 2025-01-08 Guido Consonni , Roberta Paroli

Structural and functional neuroimaging modalities provide complementary windows into brain organization: structural imaging characterizes neural tissue anatomy and microstructure, while functional imaging captures dynamic patterns of neural…

Methodology · Statistics 2026-03-24 Sakul Mahat , Sharmistha Guha , Jessica Bernard

Many leading self-supervised methods for unsupervised representation learning, in particular those for embedding image features, are built on variants of the instance discrimination task, whose optimization is known to be prone to…

Computer Vision and Pattern Recognition · Computer Science 2024-08-06 Daniel Shalam , Simon Korman

Understanding representational similarity between neural recordings and computational models is essential for neuroscience, yet remains challenging to measure reliably due to the constraints on the number of neurons that can be recorded…

Disordered Systems and Neural Networks · Physics 2025-10-27 Hyunmo Kang , Abdulkadir Canatar , SueYeon Chung

Analysis of brain connectivity is important for understanding how information is processed by the brain. We propose a novel Bayesian vector autoregression (VAR) hierarchical model for analyzing brain connectivity in a resting-state fMRI…

Applications · Statistics 2021-12-09 Bertil Wegmann , Anders Lundquist , Anders Eklund , Mattias Villani

Reliable classification and detection of certain medical conditions, in images, with state-of-the-art semantic segmentation networks, require vast amounts of pixel-wise annotation. However, the public availability of such datasets is…

Computer Vision and Pattern Recognition · Computer Science 2023-03-17 Erik Ostrowski , Bharath Srinivas Prabakaran , Muhammad Shafique

This technical report revisits the analysis of family-wise error rates in statistical parametric mapping - using random field theory - reported in (Eklund et al., 2015). Contrary to the understandable spin that these sorts of analyses…

Applications · Statistics 2016-06-28 Guillaume Flandin , Karl J. Friston

The Segment Anything Model (SAM) has achieved remarkable successes in the realm of natural image segmentation, but its deployment in the medical imaging sphere has encountered challenges. Specifically, the model struggles with medical…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Shreyank N Gowda , David A. Clifton

Semantic segmentation in a supervised learning manner has achieved significant progress in recent years. However, its performance usually drops dramatically due to the data-distribution discrepancy between seen and unseen domains when we…

Computer Vision and Pattern Recognition · Computer Science 2021-09-01 Jian Zhang , Lei Qi , Yinghuan Shi , Yang Gao

We explore the feasibility and potential of building a ground-truth-free evaluation model to assess the quality of segmentations generated by the Segment Anything Model (SAM) and its variants in medical imaging. This evaluation model…

Image and Video Processing · Electrical Eng. & Systems 2024-09-25 Ahjol Senbi , Tianyu Huang , Fei Lyu , Qing Li , Yuhui Tao , Wei Shao , Qiang Chen , Chengyan Wang , Shuo Wang , Tao Zhou , Yizhe Zhang

Given genetic variations and various phenotypical traits, such as Magnetic Resonance Imaging (MRI) features, we consider two important and related tasks in biomedical research: i)to select genetic and phenotypical markers for disease…

Machine Learning · Computer Science 2013-10-17 Shandian Zhe , Zenglin Xu , Yuan Qi

The variability introduced by differences in MRI scanner models, acquisition protocols, and imaging sites hinders consistent analysis and generalizability across multicenter studies. We present a novel image-based harmonization framework…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Luca Caldera , Lara Cavinato , Francesca Ieva

Normative modelling is an emerging method for understanding the underlying heterogeneity within brain disorders like Alzheimer Disease (AD) by quantifying how each patient deviates from the expected normative pattern that has been learned…

Image and Video Processing · Electrical Eng. & Systems 2026-02-06 Sayantan Kumar , Philip Payne , Aristeidis Sotiras

Deep neural networks often suffer from poor generalization due to complex and non-convex loss landscapes. Sharpness-Aware Minimization (SAM) is a popular solution that smooths the loss landscape by minimizing the maximized change of…

Artificial Intelligence · Computer Science 2023-07-03 Peng Mi , Li Shen , Tianhe Ren , Yiyi Zhou , Tianshuo Xu , Xiaoshuai Sun , Tongliang Liu , Rongrong Ji , Dacheng Tao

The paper investigates the fundamental convergence properties of Sharpness-Aware Minimization (SAM), a recently proposed gradient-based optimization method [Foret et al., 2021] that significantly improves the generalization of deep neural…

Optimization and Control · Mathematics 2024-10-22 Pham Duy Khanh , Hoang-Chau Luong , Boris S. Mordukhovich , Dat Ba Tran

Weakly supervised semantic segmentation (WSSS) trains dense pixel-level segmentation models from partial or coarse annotations such as bounding boxes, scribbles, or image-level tags. While recent work leverages foundation models such as the…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Stefano Colamonaco , Andrei-Bogdan Florea , Jaron Maene

Normative modeling is an emerging and promising approach to effectively study disorder heterogeneity in individual participants. In this study, we propose a novel normative modeling method by combining conditional variational autoencoder…

Machine Learning · Computer Science 2022-11-17 Xuetong Wang , Kanhao Zhao , Rong Zhou , Alex Leow , Ricardo Osorio , Yu Zhang , Lifang He

Brain vessel segmentation of MR scans is a critical step in the diagnosis of cerebrovascular diseases. Due to the fine vessel structure, manual vessel segmentation is time consuming. Therefore, automatic deep learning (DL) based…

Image and Video Processing · Electrical Eng. & Systems 2025-03-31 Omini Rathore , Richard Paul , Abigail Morrison , Hanno Scharr , Elisabeth Pfaehler

Semi-supervised learning (SSL) for medical image segmentation is a challenging yet highly practical task, which reduces reliance on large-scale labeled dataset by leveraging unlabeled samples. Among SSL techniques, the weak-to-strong…

Computer Vision and Pattern Recognition · Computer Science 2024-10-18 Shiao Xie , Hongyi Wang , Ziwei Niu , Hao Sun , Shuyi Ouyang , Yen-Wei Chen , Lanfen Lin

Semi-supervised learning has made significant strides in the medical domain since it alleviates the heavy burden of collecting abundant pixel-wise annotated data for semantic segmentation tasks. Existing semi-supervised approaches enhance…

Computer Vision and Pattern Recognition · Computer Science 2021-12-03 Xu Zheng , Chong Fu , Haoyu Xie , Jialei Chen , Xingwei Wang , Chiu-Wing Sham