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Training data are usually limited or heterogeneous in many chemical and biological applications. Existing machine learning models for chemistry and materials science fail to consider generalizing beyond training domains. In this article, we…

Machine Learning · Computer Science 2023-10-31 Fang Wu , Nicolas Courty , Shuting Jin , Stan Z. Li

AI-assisted molecular optimization is a very active research field as it is expected to provide the next-generation drugs and molecular materials. An important difficulty is that the properties to be optimized rely on costly evaluations.…

Machine Learning · Computer Science 2025-05-19 Jules Leguy , Thomas Cauchy , Beatrice Duval , Benoit Da Mota

Multilingual neural machine translation (MNMT) learns to translate multiple language pairs with a single model, potentially improving both the accuracy and the memory-efficiency of deployed models. However, the heavy data imbalance between…

Computation and Language · Computer Science 2021-09-10 Chunting Zhou , Daniel Levy , Xian Li , Marjan Ghazvininejad , Graham Neubig

This paper studies the black-box optimization task which aims to find the maxima of a black-box function using a static set of its observed input-output pairs. This is often achieved via learning and optimizing a surrogate function with…

Machine Learning · Computer Science 2025-10-24 Manh Cuong Dao , The Hung Tran , Phi Le Nguyen , Thao Nguyen Truong , Trong Nghia Hoang

Back-translation (BT) has become one of the de facto components in unsupervised neural machine translation (UNMT), and it explicitly makes UNMT have translation ability. However, all the pseudo bi-texts generated by BT are treated equally…

Computation and Language · Computer Science 2021-09-24 Jinliang Lu , Jiajun Zhang

Deep learning has revolutionized human society, yet the black-box nature of deep neural networks hinders further application to reliability-demanded industries. In the attempt to unpack them, many works observe or impact internal variables…

Computer Vision and Pattern Recognition · Computer Science 2023-03-09 Borui Zhang , Wenzhao Zheng , Jie Zhou , Jiwen Lu

While it has become common to perform automated translations on natural language, performing translations between different representations of mathematical formulae has thus far not been possible. We implemented the first translator for…

Machine Learning · Computer Science 2019-03-27 Felix Petersen , Moritz Schubotz , Bela Gipp

We propose a novel decoding approach for neural machine translation (NMT) based on continuous optimisation. We convert decoding - basically a discrete optimization problem - into a continuous optimization problem. The resulting constrained…

Computation and Language · Computer Science 2017-07-25 Cong Duy Vu Hoang , Gholamreza Haffari , Trevor Cohn

Neural Machine translation is a challenging task due to the inherent complex nature and the fluidity that natural languages bring. Nonetheless, in recent years, it has achieved state-of-the-art performance in several language pairs.…

Computation and Language · Computer Science 2023-04-19 Vakul Goyle , Parvathy Krishnaswamy , Kannan Girija Ravikumar , Utsa Chattopadhyay , Kartikay Goyle

We describe a multi-task learning approach to train a Neural Machine Translation (NMT) model with a Relevance-based Auxiliary Task (RAT) for search query translation. The translation process for Cross-lingual Information Retrieval (CLIR)…

Information Retrieval · Computer Science 2019-06-18 Sheikh Muhammad Sarwar , Hamed Bonab , James Allan

The deployment of large-scale generative models is often restricted by their potential risk of causing harm to users in unpredictable ways. We focus on the problem of black-box red teaming, where a red team generates test cases and…

Artificial Intelligence · Computer Science 2023-05-30 Deokjae Lee , JunYeong Lee , Jung-Woo Ha , Jin-Hwa Kim , Sang-Woo Lee , Hwaran Lee , Hyun Oh Song

Prior work has proved that Translation memory (TM) can boost the performance of Neural Machine Translation (NMT). In contrast to existing work that uses bilingual corpus as TM and employs source-side similarity search for memory retrieval,…

Computation and Language · Computer Science 2021-06-03 Deng Cai , Yan Wang , Huayang Li , Wai Lam , Lemao Liu

In this work, we propose a simple but effective method to interpret black-box machine learning models globally. That is, we use a compact binary tree, the interpretation tree, to explicitly represent the most important decision rules that…

Machine Learning · Computer Science 2018-05-24 Chengliang Yang , Anand Rangarajan , Sanjay Ranka

Retrieval-augmented language models can better adapt to changes in world state and incorporate long-tail knowledge. However, most existing methods retrieve only short contiguous chunks from a retrieval corpus, limiting holistic…

Computation and Language · Computer Science 2024-02-01 Parth Sarthi , Salman Abdullah , Aditi Tuli , Shubh Khanna , Anna Goldie , Christopher D. Manning

Searching for novel molecular compounds with desired properties is an important problem in drug discovery. Many existing frameworks generate molecules one atom at a time. We instead propose a flexible editing paradigm that generates…

Biomolecules · Quantitative Biology 2021-11-02 Benson Chen , Xiang Fu , Regina Barzilay , Tommi Jaakkola

There is a great need for improved statistical sampling in a range of physical, chemical and biological systems. Even simulations based on correct algorithms suffer from statistical error, which can be substantial or even dominant when slow…

Computational Physics · Physics 2007-11-09 F. Marty Ytreberg , Daniel M. Zuckerman

Conventional retrieval-augmented neural machine translation (RANMT) systems leverage bilingual corpora, e.g., translation memories (TMs). Yet, in many settings, monolingual corpora in the target language are often available. This work…

Computation and Language · Computer Science 2025-10-02 Maxime Bouthors , Josep Crego , François Yvon

Black-box optimization (BBO) involves functions that are unknown, inexact and/or expensive-to-evaluate. Existing BBO algorithms face several challenges, including high computational cost from extensive evaluations, difficulty in handling…

Optimization and Control · Mathematics 2025-09-26 Zixuan Zhang , Xiaowei Song , Jiaming Li , Yujiao Zeng , Yaling Nie , Min Zhu , Dongyun Lu , Yibo Zhang , Xin Xiao , Jie Li

Despite significant progress of generative models in the natural sciences, their controllability remains challenging. One fundamentally missing aspect of molecular or protein generative models is an inductive bias that can reflect…

Machine Learning · Computer Science 2023-08-25 Jannis Born , Matteo Manica

We aim to better exploit the limited amounts of parallel text available in low-resource settings by introducing a differentiable reconstruction loss for neural machine translation (NMT). This loss compares original inputs to reconstructed…

Computation and Language · Computer Science 2019-04-05 Xing Niu , Weijia Xu , Marine Carpuat
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