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Multi-arm multi-stage trial designs can bring notable gains in efficiency to the drug development process. However, for normally distributed endpoints, the determination of a design typically depends on the assumption that the patient…

Methodology · Statistics 2017-10-11 Michael Grayling , James Wason , Adrian Mander

Engineering design problems are often modeled as multi-objective optimization tasks in which a scalarized utility function selects an optimal design from the Pareto set. In practice, preferences are imperfectly known, so uncertainty in the…

Applications · Statistics 2026-05-01 Chia-Ruei Liu , Yongjia Song , Qiong Zhang , Cameron Turner

The structures for the expression of fault-tolerance provisions into the application software are the central topic of this dissertation. Structuring techniques provide means to control complexity, the latter being a relevant factor for the…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-11-08 Vincenzo De Florio

In engineering applications almost all processes are described with the help of models. Especially forming machines heavily rely on mathematical models for control and condition monitoring. Inaccuracies during the modeling, manufacturing…

In dynamic systems that adapt to users' needs and changing environments, dependability needs cannot be avoided. This paper proposes an orthogonal fault tolerance model as a means to manage and reason about multiple fault tolerance…

Software Engineering · Computer Science 2014-04-29 Sobia K Khan

We present a fabrication uncertainty aware and robust design optimization approach that can be used to obtain robust design estimates for nonlinear, nonconvex, and expensive model functions. It is founded on Gaussian processes and a Monte…

Signal Processing · Electrical Eng. & Systems 2025-01-07 Matthias Plock , Felix Binkowski , Lin Zschiedrich , Philipp-Immanuel Schneider , Sven Burger

Many applications of machine learning methods involve an iterative protocol in which data are collected, a model is trained, and then outputs of that model are used to choose what data to consider next. For example, one data-driven approach…

Machine Learning · Computer Science 2025-04-07 Clara Fannjiang , Stephen Bates , Anastasios N. Angelopoulos , Jennifer Listgarten , Michael I. Jordan

A prediction interval covers a future observation from a random process in repeated sampling, and is typically constructed by identifying a pivotal quantity that is also an ancillary statistic. Analogously, a tolerance interval covers a…

Methodology · Statistics 2022-01-19 Geoffrey S Johnson

This paper studies the design of mechanisms that are robust to misspecification. We introduce a novel notion of robustness that connects a variety of disparate approaches and study its implications in a wide class of mechanism design…

Theoretical Economics · Economics 2021-08-31 Giuseppe Lopomo , Luca Rigotti , Chris Shannon

Mechanical compliance is a key design parameter for dynamic contact-rich manipulation, affecting task success and safety robustness over contact geometry variation. Design of soft robotic structures, such as compliant fingers, requires…

Robotics · Computer Science 2025-09-15 Richard Matthias Hartisch , Alexander Rother , Jörg Krüger , Kevin Haninger

We investigate the problem of synthesizing distributionally robust control policies for stochastic systems under safety and reach-avoid specifications. Using a game-theoretical framework, we consider the setting where the probability…

Systems and Control · Electrical Eng. & Systems 2025-11-04 Yu Chen , Yuda Li , Shaoyuan Li , Xiang Yin

Embedded systems interaction with environment inherently complicates understanding of requirements and their correct implementation. However, product uncertainty is highest during early stages of development. Design verification is an…

Software Engineering · Computer Science 2011-12-20 Hara Gopal Mani Pakala , Dr. Plh Varaprasad , Dr. Raju Kvsvn , Dr. Ibrahim Khan

In some high-precision industrial applications, robots are deployed to perform precision assembly tasks on mass batches of manufactured pegs and holes. If the peg and hole are designed with transition fit, machining errors may lead to…

Robotics · Computer Science 2026-03-11 Bin Wang , Jiwen Zhang , Song Wang , Dan Wu

Uncertainties influencing the dynamical systems pose a significant challenge in estimating the achievable performance of a controller aiming to control such uncertain systems. When the uncertainties are of stochastic nature, obtaining hard…

Systems and Control · Electrical Eng. & Systems 2025-07-22 Venkatraman Renganathan

Input variables in numerical models are often subject to several levels of uncertainty, usually modeled by probability distributions. In the context of uncertainty quantification applied to these models, studying the robustness of output…

Noise measurement on a population of gearbox manufactured in large number often reveals high variability due to tolerances on each gear design parameter (manufacturing errors). Gearbox noise results mainly from housing vibration induced by…

Classical Physics · Physics 2016-08-14 N. Driot , Emmanuel Rigaud , Joël Perret-Liaudet

Modern computers enable methods for design optimization that account for uncertainty in the system---so-called optimization under uncertainty. We propose a metric for OUU that measures the distance between a designer-specified probability…

Optimization and Control · Mathematics 2015-08-10 Pranay Seshadri , Paul Constantine , Gianluca Iaccarino , Geoffrey Parks

Reliability is a serious concern for future extreme-scale high-performance computing (HPC) systems. While the HPC community has developed various resilience solutions, the solution space remains fragmented. There are no formal methods and…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-11-01 Saurabh Hukerikar , Christian Engelmann

The "design phase" refers to a stage in observational studies, during which a researcher constructs a subsample that achieves a better balance in covariate distributions between the treated and untreated units. In this paper, we study the…

Econometrics · Economics 2025-09-03 Junho Choi

This paper proposes a model-based optimization method for the production of automotive seals in an extrusion process. The high production throughput, coupled with quality constraints and the inherent uncertainty of the process, encourages…

Systems and Control · Electrical Eng. & Systems 2024-10-31 Raul Cruz-Oliver , Luis Monzon , Edgar Ramirez-Laboreo , Jose-Manuel Rodriguez-Fortun
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