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Characterization of microstructures in live tissues is one of the keys to diagnosing early stages of pathology and understanding disease mechanisms. However, the extraction of reliable information on biomarkers based on microstructure…

Quantum Physics · Physics 2020-09-01 Analia Zwick , Dieter Suter , Gershon Kurizki , Gonzalo A. Alvarez

We determine the bound to the maximum achievable sensitivity in the estimation of a scalar parameter from the information contained in an optical image in the presence of quantum noise. This limit, based on the Cramer-Rao bound, is valid…

Quantum Physics · Physics 2016-08-16 Vincent Delaubert , Nicolas Treps , Claude Fabre , Hans A. Bachor , Philippe Réfrégier

The applications of spin-based quantum sensors to measurements probing fundamental physics are surveyed. Experimental methods and technologies developed for quantum information science have rapidly advanced in recent years, and these tools…

Nuclear magnetic resonance (NMR) spectroscopy provides unparalleled access to molecular structure and dynamics but is traditionally limited by weak signal strength, requiring large sample volumes and high magnetic fields. Here, we…

Applied Physics · Physics 2026-04-29 Dileep Singh , Riley W. Hooper , Christoph Findler , Utsab Banerjee , Dominik B. Bucher

The estimation of parameters characterizing dynamical processes is central to science and technology. The estimation error changes with the number N of resources employed in the experiment (which could quantify, for instance, the number of…

Quantum Physics · Physics 2012-01-10 B. M. Escher , R. L. de Matos Filho , L. Davidovich

Nanomechanical oscillators are at the heart of ultrasensitive detectors of force, mass and motion. As these detectors progress to even better sensitivity, they will encounter measurement limits imposed by the laws of quantum mechanics. For…

Mesoscale and Nanoscale Physics · Physics 2009-11-06 J. D. Teufel , T. Donner , M. A. Castellanos-Beltran , J. W. Harlow , K. W. Lehnert

This article is aimed at extending the framework of optimal control techniques to the situation where the control field values are restricted to a finite set. We propose a generalization of the standard GRAPE algorithm suited to this…

Optimization and Control · Mathematics 2015-10-28 G. Dridi , M. Lapert , Julien Salomon , D Sugny , S. J. Glaser

In quantum metrology, it is widely believed that the quantum Cramer-Rao bound is attainable bound while it is not true. In order to clarify this point, we explain why the quantum Cramer-Rao bound cannot be attained geometrically. In this…

Quantum Physics · Physics 2016-06-27 Masahito Hayashi , Sai Vinjanampathy , L. C. Kwek

Nuclear magnetic resonance (NMR) technique benefits from high magnetic field not only due to the field-enhanced measurement sensitivity and resolution, but also because it is a powerful tool to investigate field-induced physics in modern…

Instrumentation and Detectors · Physics 2023-05-05 Wenqi Wei , Qinying Liu , Le Yuan , Jian Zhang , Shiyu Liu , Rui Zhou , Yongkang Luo , Xiaotao Han

Quantum-enhanced measurements exploit quantum mechanical effects to provide ultra-precise estimates of physical variables for use in advanced technologies, such as frequency calibration of atomic clocks, gravitational waves detection, and…

Quantum Physics · Physics 2014-07-28 J. Calsamiglia , B. Gendra , R. Munoz-Tapia , E. Bagan

We provide the ultimate precision attainable in spectroscopy of a quantum emitter using single-photon pulses. We find the maximum for estimating the linewidth to be independent of the details of the emitter's bare Hamiltonian while that for…

Quantum Physics · Physics 2026-03-17 Sourav Das , Aiman Khan , Francesco Albarelli , Animesh Datta

Quantum experiments usually assume the existence of perfect, classical, reference frames, which allow for the specification of measurement settings (e.g. orientation of the Stern Gerlach magnet in spin measurements) with arbitrary…

Quantum Physics · Physics 2009-12-14 Fabio Costa , Nicholas Harrigan , Terry Rudolph , Caslav Brukner

Quantum entanglement has long been recognized as an important resource for quantum sensing. In this work, we demonstrate the use of multiple-quantum solid-state NMR for quantum sensing by creating, manipulating, and detecting large clusters…

Quantum Physics · Physics 2025-12-02 Conan Alexander , T S Mahesh

The ability to determine precisely the separation of two frequencies is fundamental to spectroscopy, yet the resolution limit poses a critical challenge: distinguishing two incoherent signals becomes impossible when their frequencies are…

Quantum Physics · Physics 2025-12-29 Qingyun Cao , Genko T. Genov , Yaoming Chu , Jianming Cai , Yu Liu , Alex Retzker , Fedor Jelezko

Precision and accuracy, as two crucial criteria for quantum metrology, have previously lacked rigorous definitions and distinctions. In this paper, we provide a unified definition of precision and accuracy from the perspective of…

Quantum Physics · Physics 2025-07-15 Cong-Gang Song , Qing-yu Cai

The Heisenberg limit provides a quadratic improvement over the standard quantum limit, and is the maximum quantum advantage that quantum sensors could provide over classical methods. This limit remains elusive, however, because of the…

Quantum Physics · Physics 2026-02-19 Yingkai Ouyang , Gavin K. Brennen

We establish the ultimate limits that quantum theory imposes on the accuracy attainable in optical ellipsometry. We show that the standard quantum limit, as usual reached when the incident light is in a coherent state, can be surpassed with…

Quantum Physics · Physics 2023-07-19 L. Rudnicki , L. L. Sanchez-Soto , G. Leuchs , R. W. Boyd

Quantum parameter estimation holds the promise of quantum technologies, in which physical parameters can be measured with much greater precision than what is achieved with classical technologies. However, how to obtain a best precision when…

Quantum Physics · Physics 2024-03-05 Jianning Li , Dianzhen Cui , X. X. Yi

Nuclear magnetic resonance is a promising experimental approach to search for ultra-light axion-like dark matter. Searches such as the cosmic axion spin-precession experiments (CASPEr) are ultimately limited by quantum-mechanical noise…

A pivotal task in quantum metrology, and quantum parameter estimation in general, is to de- sign schemes that achieve the highest precision with given resources. Standard models of quantum metrology usually assume the dynamics is fixed, the…

Quantum Physics · Physics 2017-07-18 Jing Liu , Haidong Yuan