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Medical deep learning models depend heavily on domain-specific knowledge to perform well on knowledge-intensive clinical tasks. Prior work has primarily leveraged unimodal knowledge graphs, such as the Unified Medical Language System…

Artificial Intelligence · Computer Science 2025-05-26 Xiaochen Wang , Yuan Zhong , Lingwei Zhang , Lisong Dai , Ting Wang , Fenglong Ma

Human brains lie at the core of complex neurobiological systems, where the neurons, circuits, and subsystems interact in enigmatic ways. Understanding the structural and functional mechanisms of the brain has long been an intriguing pursuit…

Neurons and Cognition · Quantitative Biology 2022-07-26 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

It is prevalent to utilize external knowledge to help machine answer questions that need background commonsense, which faces a problem that unlimited knowledge will transmit noisy and misleading information. Towards the issue of introducing…

Computation and Language · Computer Science 2021-07-06 Luxi Xing , Yue Hu , Jing Yu , Yuqiang Xie , Wei Peng

Diabetes is a worldwide health issue affecting millions of people. Machine learning methods have shown promising results in improving diabetes prediction, particularly through the analysis of diverse data types, namely gene expression data.…

Machine Learning · Computer Science 2024-04-24 Rita T. Sousa , Heiko Paulheim

Current general-purpose large language models (LLMs) commonly exhibit knowledge hallucination and insufficient domain-specific adaptability in domain-specific tasks, limiting their effectiveness in specialized question answering scenarios.…

Information Retrieval · Computer Science 2025-09-16 Mengzheng Yang , Yanfei Ren , David Osei Opoku , Ruochang Li , Peng Ren , Chunxiao Xing

Much of biomedical and healthcare data is encoded in discrete, symbolic form such as text and medical codes. There is a wealth of expert-curated biomedical domain knowledge stored in knowledge bases and ontologies, but the lack of reliable…

Artificial Intelligence · Computer Science 2020-06-25 David Chang , Ivana Balazevic , Carl Allen , Daniel Chawla , Cynthia Brandt , Richard Andrew Taylor

We introduced a methodology to efficiently exploit natural-language expressed biomedical knowledge for repurposing existing drugs towards diseases for which they were not initially intended. Leveraging on developments in Computational…

Quantitative Methods · Quantitative Biology 2014-06-17 Ruggero Gramatica , T. Di Matteo , Stefano Giorgetti , Massimo Barbiani , Dorian Bevec , Tomaso Aste

Identification of disease genes, which are a set of genes associated with a disease, plays an important role in understanding and curing diseases. In this paper, we present a biomedical knowledge graph designed specifically for this…

Knowledge graphs and large language models (LLMs) are key tools for biomedical knowledge integration and reasoning, facilitating structured organization of scientific articles and discovery of complex semantic relationships. However,…

Computation and Language · Computer Science 2025-04-01 Yichun Feng , Jiawei Wang , Ruikun He , Lu Zhou , Yixue Li

With the wide application of electronic health records (EHR) in healthcare facilities, health event prediction with deep learning has gained more and more attention. A common feature of EHR data used for deep-learning-based predictions is…

Machine Learning · Computer Science 2021-12-17 Chang Lu , Tian Han , Yue Ning

The healthcare environment is commonly referred to as "information-rich" but also "knowledge poor". Healthcare systems collect huge amounts of data from various sources: lab reports, medical letters, logs of medical tools or programs,…

Computation and Language · Computer Science 2024-01-22 Elena-Simona Apostol , Ciprian-Octavian Truică

The detection and normalization of diseases in biomedical texts are key biomedical natural language processing tasks. Disease names need not only be identified, but also normalized or linked to clinical taxonomies describing diseases such…

Computation and Language · Computer Science 2020-10-27 Dhruba Pujary , Camilo Thorne , Wilker Aziz

Sparse autoencoders (SAEs) extract millions of interpretable features from a language model, but flat feature inventories aren't very useful on their own. Domain concepts get mixed with generic and weakly grounded features, while related…

Artificial Intelligence · Computer Science 2026-04-29 John Winnicki , Abeynaya Gnanasekaran , Eric Darve

Constructing large-scaled medical knowledge graphs can significantly boost healthcare applications for medical surveillance, bring much attention from recent research. An essential step in constructing large-scale MKG is extracting…

Computer Vision and Pattern Recognition · Computer Science 2021-10-27 Jialun Wu , Yang Liu , Zeyu Gao , Tieliang Gong , Chunbao Wang , Chen Li

Modern distributed decision-making systems face significant challenges arising from data heterogeneity, dynamic environments, and the need for decentralized coordination. This paper introduces the Knowledge Sharing paradigm as an innovative…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-10 Rosario Napoli , Gabriele Morabito , Antonio Celesti , Massimo Villari , Maria Fazio

Traditional Online Public Access Catalogues (OPACs) are becoming less effective due to the rapid growth of scholarly literature. Conventional search methods, such as keyword indexing and Boolean queries, often fail to support efficient…

Digital Libraries · Computer Science 2026-04-03 M. S. Rajeevan , B. Mini Devi

With the proliferation of research means and computational methodologies, published biomedical literature is growing exponentially in numbers and volume. Cancer cell lines are frequently used models in biological and medical research that…

Computation and Language · Computer Science 2024-02-13 Ellery Smith , Rahel Paloots , Dimitris Giagkos , Michael Baudis , Kurt Stockinger

Semantic web technologies have significantly contributed with effective solutions for the problems of data integration and knowledge graph creation. However, with the rapid growth of big data in diverse domains, different interoperability…

Databases · Computer Science 2022-09-22 Samaneh Jozashoori , Maria-Esther Vidal

Recent advancements in the acquisition of various brain data sources have created new opportunities for integrating multimodal brain data to assist in early detection of complex brain disorders. However, current data integration approaches…

Image and Video Processing · Electrical Eng. & Systems 2023-05-26 Reza Shirkavand , Liang Zhan , Heng Huang , Li Shen , Paul M. Thompson

The extraction of lung lesion information from clinical and medical imaging reports is crucial for research on and clinical care of lung-related diseases. Large language models (LLMs) can be effective at interpreting unstructured text in…

Computation and Language · Computer Science 2024-11-18 Diya Li , Asim Kadav , Aijing Gao , Rui Li , Richard Bourgon