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Reachability is the problem of deciding whether there is a path from one vertex to the other in the graph. Standard graph traversal algorithms such as DFS and BFS take linear time to decide reachability however their space complexity is…

Computational Complexity · Computer Science 2019-02-06 Rahul Jain , Raghunath Tewari

The structure and function of a protein are determined by its amino acid sequence. While random mutations change a protein's sequence, evolutionary forces shape its structural fold and biological activity. Studies have shown that neutral…

Biomolecules · Quantitative Biology 2024-11-15 Pranav Kantroo , Günter P. Wagner , Benjamin B. Machta

Local search is widely used to solve combinatorial optimisation problems and to model biological evolution, but the performance of local search algorithms on different kinds of fitness landscapes is poorly understood. Here we consider how…

Data Structures and Algorithms · Computer Science 2020-11-13 Artem Kaznatcheev , David A. Cohen , Peter G. Jeavons

Evolution on neutral networks of genotypes has been found in models to concentrate on genotypes with high mutational robustness, to a degree determined by the topology of the network. Here analysis is generalized beyond neutral networks to…

Populations and Evolution · Quantitative Biology 2015-09-01 Lee Altenberg

Epistasis occurs when the effect of a mutation depends on its carrier's genetic background. Despite increasing evidence that epistasis for fitness is common, its role during evolution is contentious. Fitness landscapes, mappings of genotype…

Populations and Evolution · Quantitative Biology 2022-06-13 Claudia Bank

The notion of forbidden-transition graphs allows for a robust generalization of walks in graphs. In a forbidden-transition graph, every pair of edges incident to a common vertex is permitted or forbidden; a walk is compatible if all pairs…

Data Structures and Algorithms · Computer Science 2020-09-29 Thomas Bellitto , Shaohua Li , Karolina Okrasa , Marcin Pilipczuk , Manuel Sorge

We consider evolution of a large population, where fitness of each organism is defined by many phenotypical traits. These traits result from expression of many genes. We propose a new model of gene regulation, where gene expression is…

Populations and Evolution · Quantitative Biology 2016-09-29 John Reinitz , Sergey Vakulenko , Dmitri Grigoriev , Andreas Weber

Although there are some real world applications where the use of variable length representation (VLR) in Evolutionary Algorithm is natural and suitable, an academic framework is lacking for such representations. In this work we propose a…

Neural and Evolutionary Computing · Computer Science 2007-07-05 Michael Defoin Platel , Sebastien Verel , Manuel Clergue , Philippe Collard

The tempo and mode of an adaptive process is strongly determined by the structure of the fitness landscape that underlies it. In order to be able to predict evolutionary outcomes (even on the short term), we must know more about the nature…

Populations and Evolution · Quantitative Biology 2013-02-28 Bjørn Østman , Christoph Adami

We study the problem of accessibility in a set of classical and quantum channels admitting a group structure. Group properties of the set of channels, and the structure of the closure of the analyzed group $G$ plays a pivotal role in this…

Quantum Physics · Physics 2022-09-14 Koorosh Sadri , Fereshte Shahbeigi , Zbigniew Puchała , Karol Życzkowski

The energy and geometry of maximizing paths in integrable last passage percolation models are governed by the characteristic KPZ scaling exponents of one-third and two-thirds. When represented in scaled coordinates that respect these…

Probability · Mathematics 2020-10-13 Shirshendu Ganguly , Alan Hammond

Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic fitness landscapes that aim to capture generic features of epistatic interactions in multilocus systems. Genotypes are represented as sequences of…

Populations and Evolution · Quantitative Biology 2018-04-04 Sungmin Hwang , Benjamin Schmiegelt , Luca Ferretti , Joachim Krug

The evolutionary dynamics of molecular populations are strongly dependent on the structure of genotype spaces. The map between genotype and phenotype determines how easily genotype spaces can be navigated and the accessibility of…

Populations and Evolution · Quantitative Biology 2019-07-03 Juan Antonio García-Martín , Pablo Catalán , Susanna Manrubia , José A. Cuesta

The idea of adaptive walks on fitness landscapes as a means of studying evolutionary processes on large time scales is extended to fitness landscapes that are slowly changing over time. The influence of ruggedness and of the amount of…

Biological Physics · Physics 2009-10-31 Claus O. Wilke , Thomas Martinetz

An accessibility graph of a network contains a link, wherever there is a path of arbitrary length between two nodes. We generalize the concept of accessibility to temporal networks. Building an accessibility graph by consecutively adding…

Physics and Society · Physics 2012-10-09 Hartmut H K Lentz , Thomas Selhorst , Igor M Sokolov

We give a complete characterization of bipartite graphs having tree-like Galois lattices. We prove that the poset obtained by deleting bottom and top elements from the Galois lattice of a bipartite graph is tree-like if and only if the…

Discrete Mathematics · Computer Science 2014-06-03 Nicola Apollonio , Massimiliano Caramia , Paolo Giulio Franciosa

We consider the evolutionary trajectories traced out by an infinite population undergoing mutation-selection dynamics in static, uncorrelated random fitness landscapes. Starting from the population that consists of a single genotype, the…

Populations and Evolution · Quantitative Biology 2009-11-11 Kavita Jain , Joachim Krug

Robust and efficient design of networks on a realistic geographical space is one of the important issues for the realization of dependable communication systems. In this paper, based on a percolation theory and a geometric graph property,…

Data Analysis, Statistics and Probability · Physics 2011-11-04 Yukio Hayashi

Fisher's geometric model was originally introduced to argue that complex adaptations must occur in small steps because of pleiotropic constraints. When supplemented with the assumption of additivity of mutational effects on phenotypic…

Populations and Evolution · Quantitative Biology 2017-06-12 Sungmin Hwang , Su-Chan Park , Joachim Krug

In this paper we investigate the reachability and observability properties of a network system, running a Laplacian based average consensus algorithm, when the communication graph is a path or a cycle. More in detail, we provide necessary…

Optimization and Control · Mathematics 2015-03-19 Gianfranco Parlangeli , Giuseppe Notarstefano