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Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method to resolve biological macromolecules. In a cryo-EM experiment, the microscope produces…
Cryo-electron microscopy (cryo-EM) is an indispensable technique for determining the 3D structures of dynamic biomolecular complexes. While typically applied to image a single molecular species, cryo-EM has the potential for structure…
We present a new pipeline developed to detect and characterize faint astronomical companions at small angular separation from the host star using sets of wide-field imaging observations not specifically designed for High Contrast Imaging…
There are numerous contexts where one wishes to describe the state of a randomly evolving system. Effective solutions combine models that quantify the underlying uncertainty with available observational data to form relatively optimal…
Forward adaptive transform coding of images requires a codebook of transform matrices from which the best transform can be chosen for each macroblock. Codebook construction is a problem of designing a quantizer for Karhunen-L\'{o}eve…
Differentiating signals from the background in micrographs is a critical initial step for cryogenic electron microscopy (cryo-EM), yet it remains laborious due to low signal-to-noise ratio (SNR), the presence of contaminants and densely…
Linear block transform coding remains a fundamental component of image and video compression. Although the Discrete Cosine Transform (DCT) is widely employed in all current compression standards, its sub-optimality has sparked ongoing…
Application of Karhunen-Loeve decomposition (KLD, or singular value decomposition) is presented for analysis of the spatio-temporal dynamics of wide-aperture vertical cavity surface emitting laser (VCSEL), considered as a thin-layer system.…
Cryo-electron tomography (cryo-ET) is an imaging technique that allows three-dimensional visualization of macro-molecular assemblies under near-native conditions. Cryo-ET comes with a number of challenges, mainly low signal-to-noise and…
Single-particle cryo-electron microscopy (cryo-EM) has become one of the mainstream structural biology techniques because of its ability to determine high-resolution structures of dynamic bio-molecules. However, cryo-EM data acquisition…
Filtering in spatially-extended dynamical systems is a challenging problem with significant practical applications such as numerical weather prediction. Particle filters allow asymptotically consistent inference but require infeasibly large…
Cryo-electron microscopy (cryoEM) is an increasingly popular method for protein structure determination. However, identifying a sufficient number of particles for analysis (often >100,000) can take months of manual effort. Current…
Starlight subtraction algorithms based on the method of Karhunen-Lo\`eve eigenimages have proved invaluable to exoplanet direct imaging. However, they scale poorly in runtime when paired with differential imaging techniques. In such…
Cryogenic electron microscopy (cryo-EM) provides images from different copies of the same biomolecule in arbitrary orientations. Here, we present an end-to-end unsupervised approach that learns individual particle orientations from cryo-EM…
Aligning electron density maps from Cryogenic electron microscopy (cryo-EM) is a first key step for studying multiple conformations of a biomolecule. As this step remains costly and challenging, with standard alignment tools being…
Discrete trigonometric transforms (DTTs), such as the DCT-2 and the DST-7, are widely used in video codecs for their balance between coding performance and computational efficiency. In contrast, data-dependent transforms, such as the…
Channel-state-information (CSI) feedback methods are considered, especially for massive or very large-scale multiple-input multiple-output (MIMO) systems. To extract essential information from the CSI without redundancy that arises from the…
Cryo-electron microscopy is a revolutionary technique that can provide 3D density maps at near-atomic resolution. However, map validation is still an open issue in the field. Despite several efforts from the community, it is possible to…
A large hadron machine like the LHC with its high track multiplicities always asks for powerful tools that drastically reduce the large background while selecting signal events efficiently. Actually such tools are widely needed and used in…
In recent years, an abundance of new molecular structures have been elucidated using cryo-electron microscopy (cryo-EM), largely due to advances in hardware technology and data processing techniques. Owing to these new exciting…