Related papers: Aortic and arterial mechanics
OBJECTIVE: Assessing the biomechanical behaviour of the aortic wall in vivo can potentially improve the diagnosis and prognosis of patients with abdominal aortic aneurysms (AAA). With ultrasound, AAA wall stiffness can be estimated as the…
Active solids are a large class of materials, including both living soft tissues and artificial matter, that share the ability to undergo strain even in absence of external loads. While in engineered materials the actuation is typically…
Background: Recent studies have used basic epicardial adipose tissue (EAT) assessments (e.g., volume and mean HU) to predict risk of atherosclerosis-related, major adverse cardiovascular events (MACE). Objectives: Create novel, hand-crafted…
This work presents a novel approach for characterizing the mechanical behavior of atrial tissue using constitutive neural networks. Based on experimental biaxial tensile test data of healthy human atria, we automatically discover the most…
Fluid-structure interaction (FSI) modeling, a technique widely used to enhance imaging modalities for adult and pediatric heart diseases, has been underutilized in the context of fetal circulation because of limited data on flow conditions…
The deformation of the left atrium (LA), or its biomechanical function, is closely linked to the health of this cardiac chamber. In atrial fibrillation (AF), atrial biomechanics are significantly altered but the underlying cause of this…
Microcirculation of blood and oxygen transport play important roles in biological function of optic nerve and are directly affected by damages or pathologies. This work develops a multi-domain model for optic nerve, that includes important…
Materials that behave like machines, e.g. functional materials that are able to change shape in response to external stimuli (Bhattacharya and James, 2005), often do so by exploiting phase transitions. Shape memory materials and the tail…
In CT angiography, the accurate segmentation of abdominal aortic aneurysms (AAAs) is difficult due to large anatomical variability, low-contrast vessel boundaries, and the close proximity of organs whose intensities resemble vascular…
Mechanical forces influence the dynamics of growing tissues. Computer simulations are employed to study the importance of interfacial effects in tissue competition. It was speculated that mechanical pressure determines the competition,…
An abdominal aortic aneurysm (AAA) is a focal dilation of the aorta that, if not treated, tends to grow and may rupture. A significant unmet need in the assessment of AAA disease, for the diagnosis, prognosis and follow-up, is the…
Mechanical signaling plays a key role in biological processes like embryo development and cancer growth. One prominent way to probe mechanical properties of tissues is to study their response to externally applied forces. Using a…
Understanding corneal stiffness is valuable for improving refractive surgery, detecting corneal abnormalities, and assessing intraocular pressure. However, accurately measuring the elastic properties, particularly the tensile and shear…
The metallurgy and materials communities have long known and exploited fundamental links between chemical and structural ordering in metallic solids and their mechanical properties. The highest reported strength achievable through the…
Motile cilia are a striking example of functional cellular organelle, conserved across all the eukaryotic species. Motile cilia allow swimming of cells and small organisms and transport of liquids across epithelial tissues. Whilst the…
This paper proposes a proof of concept application of a biphasic constitutive model to identify the mechanical properties of in vivo human skin under extension. Although poromechanics theory has been extensively used to model other soft…
Active contributions to fluctuations are a direct consequence of metabolic energy consumption in living cells. Such metabolic processes continuously create active forces, which deform the membrane to control motility, proliferation as well…
Hypertension is one of the most common age-related chronic diseases and by predisposing individuals for heart failure, stroke and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite…
Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to…
During development, epithelial tissues undergo extensive morphogenesis based on coordinated changes of cell shape and position over time. Continuum mechanics describes tissue mechanical state and shape changes in terms of strain and stress.…