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Knowledge Bases (KBs) require constant up-dating to reflect changes to the world they represent. For general purpose KBs, this is often done through Relation Extraction (RE), the task of predicting KB relations expressed in text mentioning…

Computation and Language · Computer Science 2019-05-13 Peng Xu , Denilson Barbosa

Detecting protein-protein interactions (PPIs) is crucial for understanding genetic mechanisms, disease pathogenesis, and drug design. However, with the fast-paced growth of biomedical literature, there is a growing need for automated and…

Computation and Language · Computer Science 2023-12-14 Hasin Rehana , Nur Bengisu Çam , Mert Basmaci , Jie Zheng , Christianah Jemiyo , Yongqun He , Arzucan Özgür , Junguk Hur

The study of multi-type Protein-Protein Interaction (PPI) is fundamental for understanding biological processes from a systematic perspective and revealing disease mechanisms. Existing methods suffer from significant performance degradation…

Machine Learning · Computer Science 2021-06-02 Guofeng Lv , Zhiqiang Hu , Yanguang Bi , Shaoting Zhang

The widespread of Coronavirus has led to a worldwide pandemic with a high mortality rate. Currently, the knowledge accumulated from different studies about this virus is very limited. Leveraging a wide-range of biological knowledge, such as…

Molecular Networks · Quantitative Biology 2021-03-09 Junheng Hao , Chelsea Ju , Muhao Chen , Yizhou Sun , Carlo Zaniolo , Wei Wang

Automatic relationship extraction (RE) from biomedical literature is critical for managing the vast amount of scientific knowledge produced each year. In recent years, utilizing pre-trained language models (PLMs) has become the prevalent…

Computation and Language · Computer Science 2025-11-04 Mario Sänger , Ulf Leser

Text matching is the task of matching two texts and determining the relationship between them, which has extensive applications in natural language processing tasks such as reading comprehension, and Question-Answering systems. The…

Computation and Language · Computer Science 2023-08-14 Kexin Jiang , Yahui Zhao , Guozhe Jin , Zhenguo Zhang , Rongyi Cui

Background: Automatic extraction of chemical-disease relations (CDR) from unstructured text is of essential importance for disease treatment and drug development. Meanwhile, biomedical experts have built many highly-structured knowledge…

Computation and Language · Computer Science 2019-12-24 Huiwei Zhou , Chengkun Lang , Zhuang Liu , Shixian Ning , Yingyu Lin , Lei Du

Protein-protein interactions (PPIs) are of fundamental importance for the human body, and the knowledge of their existence can facilitate very important tasks like drug target developing and therapy design. The high-throughput experiments…

Molecular Networks · Quantitative Biology 2019-10-11 Andrea Moscatelli

Motivation: The biomedical literature contains a wealth of chemical-protein interactions (CPIs). Automatically extracting CPIs described in biomedical literature is essential for drug discovery, precision medicine, as well as basic…

Computation and Language · Computer Science 2020-04-27 Cong Sun , Zhihao Yang , Leilei Su , Lei Wang , Yin Zhang , Hongfei Lin , Jian Wang

This paper focuses on how to take advantage of external knowledge bases (KBs) to improve recurrent neural networks for machine reading. Traditional methods that exploit knowledge from KBs encode knowledge as discrete indicator features. Not…

Computation and Language · Computer Science 2019-02-26 Bishan Yang , Tom Mitchell

Protein-protein interaction (PPI) prediction plays a pivotal role in deciphering cellular functions and disease mechanisms. To address the limitations of traditional experimental methods and existing computational approaches in cross-modal…

Machine Learning · Computer Science 2025-04-29 Shengrui XU , Tianchi Lu , Zikun Wang , Jixiu Zhai

Protein-protein interaction (PPI) modeling has been widely studied as a binary or multi-label classification task. While emerging multimodal large language models (LLMs) can now describe single proteins, they remain unable to generate…

Computational Engineering, Finance, and Science · Computer Science 2026-05-12 Xiao Fei , Sarah Almeida Carneiro , Yang Zhang , Lawrence P. Petalidis , Achilleas Tsortos , Costas Bouyioukos , Michalis Vazirgiannis

Protein-Protein Interactions (PPIs) perform essential roles in biological functions. Although some experimental techniques have been developed to detect PPIs, they suffer from high false positive and high false negative rates. Consequently,…

Quantitative Methods · Quantitative Biology 2017-12-29 Samaneh Aghajanbaglo , Sobhan Moosavi , Maseud Rahgozar , Amir Rahimi

Identifying protein-protein interactions (PPI) is crucial for gaining in-depth insights into numerous biological processes within cells and holds significant guiding value in areas such as drug development and disease treatment. Currently,…

Quantitative Methods · Quantitative Biology 2025-01-30 Jiang Li , Yuan-Ting Li

Automatically extracting the relationships between chemicals and diseases is significantly important to various areas of biomedical research and health care. Biomedical experts have built many large-scale knowledge bases (KBs) to advance…

Computation and Language · Computer Science 2019-12-24 Huiwei Zhou , Yunlong Yang , Shixian Ning , Zhuang Liu , Chengkun Lang , Yingyu Lin , Degen Huang

We report an evaluation of the effectiveness of the existing knowledge base embedding models for relation prediction and for relation extraction on a wide range of benchmarks. We also describe a new benchmark, which is much larger and…

Computation and Language · Computer Science 2018-02-07 Peng Xu , Denilson Barbosa

Compared to the general news domain, information extraction (IE) from biomedical text requires much broader domain knowledge. However, many previous IE methods do not utilize any external knowledge during inference. Due to the exponential…

Computation and Language · Computer Science 2021-06-02 Tuan Lai , Heng Ji , ChengXiang Zhai , Quan Hung Tran

Accurately predicting complex protein-protein interactions (PPIs) is crucial for decoding biological processes, from cellular functioning to disease mechanisms. However, experimental methods for determining PPIs are computationally…

Pre-trained language representation models (PLMs) cannot well capture factual knowledge from text. In contrast, knowledge embedding (KE) methods can effectively represent the relational facts in knowledge graphs (KGs) with informative…

Computation and Language · Computer Science 2020-11-24 Xiaozhi Wang , Tianyu Gao , Zhaocheng Zhu , Zhengyan Zhang , Zhiyuan Liu , Juanzi Li , Jian Tang

We introduce a biomedical information extraction (IE) pipeline that extracts biological relationships from text and demonstrate that its components, such as named entity recognition (NER) and relation extraction (RE), outperform…

Machine Learning · Computer Science 2020-11-13 Jupinder Parmar , William Koehler , Martin Bringmann , Katharina Sophia Volz , Berk Kapicioglu