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Background: High-throughput proteomics techniques, such as mass spectrometry (MS)-based approaches, produce very high-dimensional data-sets. In a clinical setting one is often interested in how mass spectra differ between patients of…

This article discusses a partially adapted particle filter for estimating the likelihood of a nonlinear structural econometric state space models whose state transition density cannot be expressed in closed form. The filter generates the…

Methodology · Statistics 2012-09-05 Jamie Hall , Michael K. Pitt , Robert Kohn

The data-driven discovery of dynamics via machine learning is currently pushing the frontiers of modeling and control efforts, and it provides a tremendous opportunity to extend the reach of model predictive control. However, many leading…

Optimization and Control · Mathematics 2019-03-06 Eurika Kaiser , J. Nathan Kutz , Steven L. Brunton

In recent years, diffusion models, and more generally score-based deep generative models, have achieved remarkable success in various applications, including image and audio generation. In this paper, we view diffusion models as an implicit…

Statistics Theory · Mathematics 2026-02-12 Hyeok Kyu Kwon , Dongha Kim , Ilsang Ohn , Minwoo Chae

A recent line of work shows that a deep neural network with ReLU nonlinearities arises from a finite sequence of cascaded sparse coding models, the outputs of which, except for the last element in the cascade, are sparse and unobservable.…

Signal Processing · Electrical Eng. & Systems 2020-04-27 Demba Ba

Data dispersed across multiple files are commonly integrated through probabilistic linkage methods, where even minimal error rates in record matching can significantly contaminate subsequent statistical analyses. In regression problems, we…

Statistics Theory · Mathematics 2024-09-18 Abhisek Chakraborty , Saptati Datta

This study introduces a nonparametric definition of interaction and provides an approach to both interaction discovery and efficient estimation of this parameter. Using stochastic shift interventions and ensemble machine learning, our…

Methodology · Statistics 2024-07-01 David B. McCoy , Alan E. Hubbard , Alejandro Schuler , Mark J. van der Laan

Predicting whether a chemical structure shares a desired biological effect can have a significant impact for in-silico compound screening in early drug discovery. In this study, we developed a deep learning model where compound structures…

Quantitative Methods · Quantitative Biology 2020-04-03 C. Fotis , N. Meimetis , A. Sardis , L. G. Alexopoulos

Numerous fields of nonlinear physics, very different in nature, produce signals and images, that share the common feature of being essentially constituted of piecewise homogeneous phases. Analyzing signals and images from corresponding…

Data Analysis, Statistics and Probability · Physics 2020-06-17 Barbara Pascal , Nelly Pustelnik , Patrice Abry , Jean-Christophe Géminard , Valérie Vidal

Traffic flow modeling relies heavily on fundamental diagrams. However, deterministic fundamental diagrams, such as single or multi-regime models, cannot capture the uncertainty pattern that underlies traffic flow. To address this…

Applications · Statistics 2024-11-25 Yuan-Zheng Lei , Yaobang Gong , Xianfeng Terry Yang

In this paper, an evolutionary-based sparse regression algorithm is proposed and applied onto experimental data collected from a Duffing oscillator setup and numerical simulation data. Our purpose is to identify the Coulomb friction terms…

Computational Engineering, Finance, and Science · Computer Science 2020-05-19 Saeideh Khatiry Goharoodi , Kevin Dekemele , Mia Loccufier , Luc Dupre , Guillaume Crevecoeur

Differentiable particle filters are an emerging class of sequential Bayesian inference techniques that use neural networks to construct components in state space models. Existing approaches are mostly based on offline supervised training…

Machine Learning · Computer Science 2023-12-19 Jiaxi Li , Xiongjie Chen , Yunpeng Li

By providing substantial amounts of data and standardized evaluation protocols, datasets in computer vision have helped fuel advances across all areas of visual recognition. But even in light of breakthrough results on recent benchmarks, it…

Computer Vision and Pattern Recognition · Computer Science 2018-07-06 Brandon RichardWebster , Samuel E. Anthony , Walter J. Scheirer

Fluorescent and luminescent gene reporters allow us to dynamically quantify changes in molecular species concentration over time on the single cell level. The mathematical modeling of their interaction through multivariate dynamical models…

Quantitative Methods · Quantitative Biology 2009-07-07 Michal Komorowski , Barbel Finkenstadt , Claire V. Harper , David A. Rand

Datasets in the Natural Sciences are often curated with the goal of aiding scientific understanding and hence may not always be in a form that facilitates the application of machine learning. In this paper, we identify three trends within…

Chemical Physics · Physics 2021-05-07 Ryan-Rhys Griffiths , Philippe Schwaller , Alpha A. Lee

Sparse regression has recently emerged as an attractive approach for discovering models of spatiotemporally complex dynamics directly from data. In many instances, such models are in the form of nonlinear partial differential equations…

Dynamical Systems · Mathematics 2020-01-29 Patrick A. K. Reinbold , Daniel R. Gurevich , Roman O. Grigoriev

Detector simulation and reconstruction are a significant computational bottleneck in particle physics. We develop Particle-flow Neural Assisted Simulations (Parnassus) to address this challenge. Our deep learning model takes as input a…

Data Analysis, Statistics and Probability · Physics 2024-11-22 Etienne Dreyer , Eilam Gross , Dmitrii Kobylianskii , Vinicius Mikuni , Benjamin Nachman , Nathalie Soybelman

The convergence of statistical learning and molecular physics is transforming our approach to modeling biomolecular systems. Physics-informed machine learning (PIML) offers a systematic framework that integrates data-driven inference with…

Biomolecules · Quantitative Biology 2025-11-11 Aaryesh Deshpande

Several approximate inference methods have been proposed for deep discrete latent variable models. However, non-parametric methods which have previously been successfully employed for classical sparse coding models have largely been…

Machine Learning · Computer Science 2023-03-16 Arunesh Mittal , Kai Yang , Paul Sajda , John Paisley

We propose a method for inference on moderately high-dimensional, nonlinear, non-Gaussian, partially observed Markov process models for which the transition density is not analytically tractable. Markov processes with intractable transition…

Methodology · Statistics 2020-04-02 Joonha Park , Edward L. Ionides