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An important limitation of standard multiple testing procedures is that the null distribution should be known. Here, we consider a null distribution-free approach for multiple testing in the following semi-supervised setting: the user does…

Statistics Theory · Mathematics 2022-12-08 David Mary , Etienne Roquain

We are interested in testing properties of distributions with systematically mislabeled samples. Our goal is to make decisions about unknown probability distributions, using a sample that has been collected by a confused collector, such as…

Data Structures and Algorithms · Computer Science 2023-11-27 Renato Ferreira Pinto , Nathaniel Harms

The traditional approaches to false discovery rate (FDR) control in multiple hypothesis testing are usually based on the null distribution of a test statistic. However, all types of null distributions, including the theoretical,…

Methodology · Statistics 2021-04-13 Kun He , Mengjie Li , Yan Fu , Fuzhou Gong , Xiaoming Sun

Despite the popularity of the false discovery rate (FDR) as an error control metric for large-scale multiple testing, its close Bayesian counterpart the local false discovery rate (lfdr), defined as the posterior probability that a…

Methodology · Statistics 2023-09-22 Jake A. Soloff , Daniel Xiang , William Fithian

We study the properties of false discovery rate (FDR) thresholding, viewed as a classification procedure. The "0"-class (null) is assumed to have a known density while the "1"-class (alternative) is obtained from the "0"-class either by…

Methodology · Statistics 2013-03-06 Pierre Neuvial , Etienne Roquain

We investigate the multiplicity model with m values of some test statistic independently drawn from a mixture of no effect (null) and positive effect (alternative), where we seek to identify, the alternative test results with a controlled…

Methodology · Statistics 2024-02-06 Zhiwen Jiang , Stephan Morgenthaler

In a novel approach to the multiple testing problem, Efron (2004; 2007) formulated estimators of the distribution of test statistics or nominal p-values under a null distribution suitable for modeling the data of thousands of unaffected…

Methodology · Statistics 2012-10-30 David R. Bickel

We consider the problem of comparing a reference distribution with several other distributions. Given a sample from both the reference and the comparison groups, we aim to identify the comparison groups whose distributions differ from that…

Methodology · Statistics 2025-11-26 Yonghoon Lee , Edgar Dobriban , Eric Tchetgen Tchetgen

In a multiple testing framework, we propose a method that identifies the interval with the highest estimated false discovery rate of P-values and rejects the corresponding null hypotheses. Unlike the Benjamini-Hochberg method, which does…

Statistics Theory · Mathematics 2018-08-03 Shiyun Chen , Andrew Ying , Ery Arias-Castro

This work studies distributed multiple testing with false discovery rate (FDR) control in the presence of Byzantine attacks, where an adversary captures a fraction of the nodes and corrupts their reported p-values. We focus on two baseline…

Signal Processing · Electrical Eng. & Systems 2025-04-28 Daofu Zhang , Mehrdad Pournaderi , Yu Xiang , Pramod Varshney

It is frequently of interest to jointly analyze multiple sequences of multiple tests in order to identify simultaneous signals, defined as features tested in multiple studies whose test statistics are non-null in each. In many problems,…

Methodology · Statistics 2019-01-16 Sihai Dave Zhao , Yet Tien Nguyen

The scan statistic is by far the most popular method for anomaly detection, being popular in syndromic surveillance, signal and image processing, and target detection based on sensor networks, among other applications. The use of the scan…

Methodology · Statistics 2016-11-28 Ery Arias-Castro , Rui M. Castro , Ervin Tánczos , Meng Wang

A generative model may generate utter nonsense when it is fit to maximize the likelihood of observed data. This happens due to "model error," i.e., when the true data generating distribution does not fit within the class of generative…

Machine Learning · Computer Science 2018-02-21 Steve Hanneke , Adam Kalai , Gautam Kamath , Christos Tzamos

Within a Bayesian decision theoretic framework we investigate some asymptotic optimality properties of a large class of multiple testing rules. A parametric setup is considered, in which observations come from a normal scale mixture model…

Statistics Theory · Mathematics 2012-11-22 Małgorzata Bogdan , Arijit Chakrabarti , Florian Frommlet , Jayanta K. Ghosh

Large-scale multiple testing is a fundamental problem in high dimensional statistical inference. It is increasingly common that various types of auxiliary information, reflecting the structural relationship among the hypotheses, are…

Methodology · Statistics 2021-10-07 Hongyuan Cao , Jun Chen , Xianyang Zhang

In this paper we propose a computationally efficient multiple hypothesis testing procedure for persistent homology. The computational efficiency of our procedure is based on the observation that one can empirically simulate a null…

Computational Geometry · Computer Science 2022-08-29 Mikael Vejdemo-Johansson , Sayan Mukherjee

The relative-error property testing model was introduced in [CDHLNSY24] to facilitate the study of property testing for "sparse" Boolean-valued functions, i.e. ones for which only a small fraction of all input assignments satisfy the…

Data Structures and Algorithms · Computer Science 2026-04-03 Xi Chen , Anindya De , Yizhi Huang , Shivam Nadimpalli , Rocco A. Servedio , Tianqi Yang

Multiple hypothesis testing is a core problem in statistical inference and arises in almost every scientific field. Given a set of null hypotheses $\mathcal{H}(n) = (H_1,\dotsc, H_n)$, Benjamini and Hochberg introduced the false discovery…

Statistics Theory · Mathematics 2017-07-10 Adel Javanmard , Andrea Montanari

We consider the problem of testing for a dose-related effect based on a candidate set of (typically nonlinear) dose-response models using likelihood-ratio tests. For the considered models this reduces to assessing whether the slope…

Methodology · Statistics 2015-10-22 Georg Gutjahr , Björn Bornkamp

We study distribution testing without direct access to a source of relevant data, but rather to one where only a tiny fraction is relevant. To enable this, we introduce the following verification query model. The goal is to perform a…

Data Structures and Algorithms · Computer Science 2025-09-23 Hadley Black , Christopher Ye
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