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In realistic scenarios, multivariate timeseries evolve over case-by-case time-scales. This is particularly clear in medicine, where the rate of clinical events varies by ward, patient, and application. Increasingly complex models have been…

Machine Learning · Computer Science 2020-03-06 Jacob Deasy , Ari Ercole , Pietro Liò

Deep learning-based predictive models, leveraging Electronic Health Records (EHR), are receiving increasing attention in healthcare. An effective representation of a patient's EHR should hierarchically encompass both the temporal…

Machine Learning · Computer Science 2024-05-08 Jiayuan Chen , Changchang Yin , Yuanlong Wang , Ping Zhang

Machine learning is used in medicine to support physicians in examination, diagnosis, and predicting outcomes. One of the most dynamic area is the usage of patient generated health data from intensive care units. The goal of this paper is…

Accurate and explainable health event predictions are becoming crucial for healthcare providers to develop care plans for patients. The availability of electronic health records (EHR) has enabled machine learning advances in providing these…

Machine Learning · Computer Science 2021-05-18 Chang Lu , Chandan K. Reddy , Prithwish Chakraborty , Samantha Kleinberg , Yue Ning

The field of deep-learning-based ECG analysis has been largely dominated by convolutional architectures. This work explores the prospects of applying the recently introduced structured state space models (SSMs) as a particularly promising…

Machine Learning · Computer Science 2022-11-15 Temesgen Mehari , Nils Strodthoff

The wide adoption of Electronic Health Records (EHR) has resulted in large amounts of clinical data becoming available, which promises to support service delivery and advance clinical and informatics research. Deep learning techniques have…

Machine Learning · Computer Science 2022-02-14 Thanh Nguyen-Duc , Natasha Mulligan , Gurdeep S. Mannu , Joao H. Bettencourt-Silva

Spatio-temporal data and processes are prevalent across a wide variety of scientific disciplines. These processes are often characterized by nonlinear time dynamics that include interactions across multiple scales of spatial and temporal…

Machine Learning · Statistics 2017-08-18 Patrick L. McDermott , Christopher K. Wikle

Spatio-temporal signals arising from event-driven biological processes, such as surface electromyography (sEMG), exhibit asynchronous and highly structured activation patterns that are challenging to model using conventional discrete or…

Machine Learning · Computer Science 2026-05-05 Magnus Bengtsson

In this paper, we propose a deep generative time series approach using latent temporal processes for modeling and holistically analyzing complex disease trajectories. We aim to find meaningful temporal latent representations of an…

Accurate and reliable forecasting of epidemic incidences is critical for public health preparedness, yet it remains a challenging task due to complex nonlinear temporal dependencies and heterogeneous spatial interactions. Often, point…

Machine Learning · Statistics 2026-03-10 Rajdeep Pathak , Tanujit Chakraborty

Deep neural networks are often applied to medical images to automate the problem of medical diagnosis. However, a more clinically relevant question that practitioners usually face is how to predict the future trajectory of a disease.…

Image and Video Processing · Electrical Eng. & Systems 2023-09-20 Huy Hoang Nguyen , Matthew B. Blaschko , Simo Saarakkala , Aleksei Tiulpin

The integration of multimodal Electronic Health Records (EHR) data has significantly advanced clinical predictive capabilities. Existing models, which utilize clinical notes and multivariate time-series EHR data, often fall short of…

Computation and Language · Computer Science 2025-02-27 Yinghao Zhu , Changyu Ren , Zixiang Wang , Xiaochen Zheng , Shiyun Xie , Junlan Feng , Xi Zhu , Zhoujun Li , Liantao Ma , Chengwei Pan

Electronic Health Records (EHR) contain valuable clinical information for predicting patient outcomes and guiding healthcare decisions. However, effectively modeling Electronic Health Records (EHRs) requires addressing data heterogeneity…

Machine Learning · Computer Science 2025-07-22 Junhan Yu , Zhunyi Feng , Junwei Lu , Tianxi Cai , Doudou Zhou

Clinicians spend a significant amount of time inputting free-form textual notes into Electronic Health Records (EHR) systems. Much of this documentation work is seen as a burden, reducing time spent with patients and contributing to…

Computation and Language · Computer Science 2018-08-09 Peter J. Liu

Simulation is a powerful tool for exploring uncertainty. Its potential in clinical medicine is transformative and includes personalized treatment planning and virtual clinical trials. However, simulating patient trajectories is challenging…

Artificial Intelligence · Computer Science 2026-01-27 Yu Akagi , Tomohisa Seki , Hiromasa Ito , Toru Takiguchi , Kazuhiko Ohe , Yoshimasa Kawazoe

Mental disorders present challenges in diagnosis and treatment due to their complex and heterogeneous nature. Electroencephalogram (EEG) has shown promise as a potential biomarker for these disorders. However, existing methods for analyzing…

Methodology · Statistics 2024-01-30 Xingche Guo , Bin Yang , Ji Meng Loh , Qinxia Wang , Yuanjia Wang

Clinical data for ambulatory care, which accounts for 90% of the nations healthcare spending, is characterized by relatively small sample sizes of longitudinal data, unequal spacing between visits for each patient, with unequal numbers of…

Machine Learning · Computer Science 2018-12-03 Beau Norgeot , Dmytro Lituiev , Benjamin S. Glicksberg , Atul J. Butte

Electronic Health Records (EHRs) enable deep learning for clinical predictions, but the optimal method for representing patient data remains unclear due to inconsistent evaluation practices. We present the first systematic benchmark to…

Machine Learning · Computer Science 2025-10-13 Tianyi Chen , Mingcheng Zhu , Zhiyao Luo , Tingting Zhu

This article presents a novel method for predicting suicidal ideation from Electronic Health Records (EHR) and Ecological Momentary Assessment (EMA) data using deep sequential models. Both EHR longitudinal data and EMA question forms are…

This study introduces an integrated framework for predictive causal inference designed to overcome limitations inherent in conventional single model approaches. Specifically, we combine a Hidden Markov Model (HMM) for spatial health state…

Methodology · Statistics 2025-10-31 Byunghee Lee , Hye Yeon Sin , Joonsung Kang