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Biomolecular condensates in cells are often rich in catalytically-active enzymes. This is particularly true in the case of the large enzymatic complexes known as metabolons, which contain different enzymes that participate in the same…

Subcellular Processes · Quantitative Biology 2021-10-20 Vincent Ouazan-Reboul , Jaime Agudo-Canalejo , Ramin Golestanian

Differences in activities in colloidal particles are sufficient to drive phase separation between active and passive (or less active) particles, even if they have only excluded volume interactions. In this paper, we study the phase…

Soft Condensed Matter · Physics 2020-05-27 Efe Ilker , Jean-François Joanny

Phase-separated biomolecular condensates exhibit a wide range of dynamical properties, which depend on the sequences of the constituent proteins and RNAs. However, it is unclear to what extent condensate dynamics can be tuned without also…

Biomolecules · Quantitative Biology 2024-07-31 Yaxin An , Michael A. Webb , William M. Jacobs

Partially phase-separated liquid-crystal/polymer dispersions display highly fibrillar domain morphologies that are dramatically different from the typical structures found in isotropic mixtures. To explain this, we numerically explore the…

Soft Condensed Matter · Physics 2009-10-31 Amelia M. Lapena , Sharon C. Glotzer , Stephen A. Langer , Andrea J. Liu

New insights into phase separation in colloidal suspensions are provided via a new dynamical theory based on the Polydisperse Lattice-Gas model. The model gives a simplified description of polydisperse colloids, incorporating a hard-core…

Soft Condensed Matter · Physics 2017-08-03 Pablo de Castro , Peter Sollich

Intracellular protein patterns regulate a variety of vital cellular processes such as cell division and motility, which often involve dynamic changes of cell shape. These changes in cell shape may in turn affect the dynamics of…

Pattern Formation and Solitons · Physics 2023-07-19 Laeschkir Würthner , Andriy Goychuk , Erwin Frey

Various biological and chemical processes lead to the nucleation and growth of non-wetting fluid bubbles within the pore space of a granular medium, such as the formation of gas bubbles in liquid-saturated lake-bed sediments. In…

Soft Condensed Matter · Physics 2022-05-13 Oliver W. Paulin , Liam C. Morrow , Matthew G. Hennessy , Christopher W. MacMinn

Membrane shape fluctuations induce attractive interactions between rigid inclusions. Previous analytical studies showed that the fluctuation-induced pair interactions are rather small compared to thermal energies, but also that multi-body…

Soft Condensed Matter · Physics 2009-11-07 Thomas R Weikl

The interactions of a protein, its phase behavior, and ultimately, its ability to function, are all influenced by the interactions between the protein and its hydration waters. Here we study proteins with a variety of sizes, shapes,…

Chemical Physics · Physics 2018-11-08 Nicholas B. Rego , Erte Xi , Amish J. Patel

Liquid-liquid phase separation of liquids exhibiting interconversion between alternative states has been proposed as an underlying mechanism for fluid polyamorphism, and may be of relevance to protein function and intracellular…

Statistical Mechanics · Physics 2021-12-08 Betul Uralcan , Thomas J. Longo , Mikhail A. Anisimov , Frank H. Stillinger , Pablo G. Debenedetti

The interaction of phase-separating systems with chemical reactions is of great interest in various contexts, from biology to material science. In biology, phase separation is thought to be the driving force behind the formation of…

Soft Condensed Matter · Physics 2026-01-08 Franco Blanchini , Elisa Franco , Giulia Giordano , Dino Osmanovic

A striking feature of the collective behavior of spherical microswimmers is that for sufficiently strong self-propulsion they phase-separate into a dense cluster coexisting with a low-density dis- ordered surrounding. Extending our previous…

Soft Condensed Matter · Physics 2016-10-31 Johannes Blaschke , Maurice Maurer , Karthik Menon , Andreas Zöttl , Holger Stark

A molecular model is proposed of a bilayer consisting of fully saturated DPPC and mono unsaturated DOPC. The model not only encompasses the constant density within the hydrophobic core of the bilayer, but also the tendency of chain segments…

Biological Physics · Physics 2009-11-10 R. Elliott , K. Katsov , M. Schick , I. Szleifer

We review recent experimental, numerical, and analytical results on active suspensions of self-propelled colloidal beads moving in (quasi) two dimensions. Active colloids form part of the larger theme of active matter, which is noted for…

Soft Condensed Matter · Physics 2014-09-03 Julian Bialké , Thomas Speck , Hartmut Löwen

Phase separation plays an role in determining the self-assembly of biological and soft-matter systems. In biological systems, liquid-liquid phase separation inside a cell leads to the formation of various macromolecular aggregates. The…

Soft Condensed Matter · Physics 2024-03-26 Tanmay Biswas , Gerhard Kahl , Gaurav P. Shrivastav

The intrinsic property of proteins to form structural motifs such as alpha-helices and beta-sheets leads to a complex phase behavior in which proteins can assemble into various types of aggregates including crystals, liquidlike phases of…

Biomolecules · Quantitative Biology 2010-06-08 Stefan Auer , Dimo Kashchiev

The phase behavior of colloid-polymer mixtures, and of solutions of globular proteins, is often interpreted in terms of a simple model of hard spheres with short-ranged attraction. While such a model yields a qualitative understanding of…

Soft Condensed Matter · Physics 2009-10-31 M. G. Noro , N. Kern , D. Frenkel

Studies of active matter, from molecular assemblies to animal groups, have revealed two broad classes of behavior: a tendency to align yields orientational order and collective motion, whereas particle repulsion leads to self-trapping and…

Soft Condensed Matter · Physics 2021-11-23 Jie Zhang , Ricard Alert , Jing Yan , Ned S. Wingreen , Steve Granick

Complex behavior in glassforming liquids is associated with formation of a mosaic of different structures. Using bond order parameters together with topological characteristics of the bond network, we show that in the mosaic of crystalline…

Soft Condensed Matter · Physics 2013-09-24 Alexander Z. Patashinski , Mark A. Ratner , Bartosz A. Grzybowski , Rafal Orlik , Antoni C. Mitus

Phase separation driven by nonequilibrium fluctuations is a hallmark of both living and synthetic active matter. Unlike equilibrium systems, where ordered states arise from the minimization of free energy, active systems are fueled by a…

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