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The paper proposes a time-adaptive optimization approach for determining the time-dependent immune response function in a mathematical model of acute HIV infection, using clinical data from four untreated patients. We formulate the problem…

Numerical Analysis · Mathematics 2025-08-19 L. Beilina , I. Gainova , G. Bocharov

In this paper we consider the evolution of the HIV infection under a highly effective treatment based on a combination of RTI and/or PI drugs. This is usually modelled with a set of ODEs where the drug efficacy is a constant. In this paper…

Populations and Evolution · Quantitative Biology 2007-05-23 G. Della Rocca , M. Sammartino , L. Seta

This paper presents a reliable and efficient residual-based a posteriori error analysis for the symmetric $H(\operatorname{div}\operatorname{div})$ mixed finite element method for the Kirchhoff-Love plate bending problem with mixed boundary…

Numerical Analysis · Mathematics 2025-08-13 Jun Hu , Rui Ma , Min Zhang

An increasing number of control techniques are introduced to HIV infection problem to explore the options of helping clinical testing, optimizing drug treatments and to study the drug resistance situations. In such cases, complete/accurate…

Optimization and Control · Mathematics 2019-07-17 Fei Sun , Kamran Turkoglu

Person re-identification is an open and challenging problem in computer vision. Majority of the efforts have been spent either to design the best feature representation or to learn the optimal matching metric. Most approaches have neglected…

Computer Vision and Pattern Recognition · Computer Science 2016-07-26 Niki Martinel , Abir Das , Christian Micheloni , Amit K. Roy-Chowdhury

In this paper, we examine a well-established model for HIV wild-type infection. The algorithm for steepest descent method for fixed final-time is stated and a modified method for free final-time is presented. The first type of cost…

Optimization and Control · Mathematics 2011-10-18 Gaurav Pachpute , Kriti Saxena

In this paper, we study optimization problems where the cost function contains time-varying parameters that are unmeasurable and evolve according to linear, yet unknown, dynamics. We propose a solution that leverages control theoretic tools…

Optimization and Control · Mathematics 2025-03-20 Shivanshu Tripathi , Abed AlRahman Al Makdah , Fabio Pasqualetti

We introduce a new version of forward stepwise regression. Our modification finds solutions to regression problems where the selected predictors appear in a structured pattern, with respect to a predefined distance measure over the…

Methodology · Statistics 2011-08-02 Daniel Percival , Kathryn Roeder , Roni Rosenfeld , Larry Wasserman

Motivated by reduction of computational complexity, this work develops sign-error adaptive filtering algorithms for estimating time-varying system parameters. Different from the previous work on sign-error algorithms, the parameters are…

Optimization and Control · Mathematics 2016-11-17 Araz Hashemi , G. Yin , Le Yi Wang

Motivation: In predicting HIV therapy outcomes, a critical clinical question is whether using historical information can enhance predictive capabilities compared with current or latest available data analysis. This study analyses whether…

We describe a method for the identification of models for dynamical systems from observational data. The method is based on the concept of symbolic regression and uses genetic programming to evolve a system of ordinary differential…

Machine Learning · Computer Science 2021-07-14 Gabriel Kronberger , Lukas Kammerer , Michael Kommenda

Identifiability is a structural property of any ODE model characterized by a set of unknown parameters. It describes the possibility of determining the values of these parameters from fusing the observations of the system inputs and…

Systems and Control · Electrical Eng. & Systems 2024-09-12 Agostino Martinelli

This paper investigates the effect of drug treatment on the standard within-host HIV model, assuming that therapy occurs periodically. It is shown that eradication is possible under these periodic regimes, and we quantitatively characterize…

Other Quantitative Biology · Quantitative Biology 2008-01-30 Patrick De Leenheer

Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its evolution is constrained by interactions between mutations in its fitness landscape. Here we show that an Ising model describing these interactions,…

Populations and Evolution · Quantitative Biology 2016-02-24 Thomas C. Butler , John P. Barton , Mehran Kardar , Arup K. Chakraborty

We propose an improved method for estimating partial differential equations and delay partial differential equations from data, using Bayesian optimization and the Bayesian information criterion to automatically find suitable…

Computational Physics · Physics 2026-02-23 Oliver Mai , Tim W. Kroll , Uwe Thiele , Oliver Kamps

To deal with the ill-posed nature of the inverse heat conduction problem (IHCP), the regularization parameter alpha can be incorporated into a minimization problem, which is known as Tikhonov regularization method, a popular technique to…

Numerical Analysis · Mathematics 2021-10-05 C. Ahn , C. Park , DI. Park , JG. Kim

In this paper we propose a framework to analyze iterative first-order optimization algorithms for time-varying convex optimization. We assume that the temporal variability is caused by a time-varying parameter entering the objective, which…

Optimization and Control · Mathematics 2026-03-05 Fabian Jakob , Andrea Iannelli

The interior penalty methods using $C^0$ Lagrange elements ($C^0$IPG) developed in the last decade for the fourth order problems are an interesting topic in academia at present. In this paper, we discuss the adaptive fashion of $C^0$IPG…

Numerical Analysis · Mathematics 2017-08-22 Hao Li , Yidu Yang

Human mesh recovery from single images remains challenging due to inherent depth ambiguity and limited generalization across domains. While recent methods combine regression and optimization approaches, they struggle with poor…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Shaurjya Mandal , Nutan Sharma , John Galeotti

In this work we introduce a differential equation model with time-delay that describes the three-stage dynamics and the two time scales observed in HIV infection. Assuming that the virus has high mutation and rapid reproduction rates that…

Biological Physics · Physics 2015-03-13 Flora S. Bacelar , Roberto F. S. Andrade , Rita M. Zorzenon dos Santos
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