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Drug repositioning offers an effective solution to drug discovery, saving both time and resources by finding new indications for existing drugs. Typically, a drug takes effect via its protein targets in the cell. As a result, it is…

Quantitative Methods · Quantitative Biology 2018-11-26 Maryam Lotfi Shahreza , Nasser Ghadiri , Seyed Rasul Mossavi , Jaleh Varshosaz , James Green

Clustering is an essential technique for discovering patterns in data. The steady increase in amount and complexity of data over the years led to improvements and development of new clustering algorithms. However, algorithms that can…

Machine Learning · Statistics 2021-03-03 Shu Wang , Jonathan G. Yabes , Chung-Chou H. Chang

Epidemiology aims at identifying subpopulations of cohort participants that share common characteristics (e.g. alcohol consumption) to explain risk factors of diseases in cohort study data. These data contain information about the…

We propose a homotopy sampling procedure, loosely based on importance sampling. Starting from a known probability distribution, the homotopy procedure generates the unknown normalization of a target distribution. In the context of…

Computation · Statistics 2021-05-05 Juan M. Restrepo , Jorge M. Ramirez

Recognizing human activities in a sequence is a challenging area of research in ubiquitous computing. Most approaches use a fixed size sliding window over consecutive samples to extract features---either handcrafted or learned…

Computer Vision and Pattern Recognition · Computer Science 2017-02-22 Rui Yao , Guosheng Lin , Qinfeng Shi , Damith Ranasinghe

The stochastic block model (SBM) is an important generative model for random graphs in network science and machine learning, useful for benchmarking community detection (or clustering) algorithms. The symmetric SBM generates a graph with…

Machine Learning · Computer Science 2016-11-17 Akshay Gadde , Eyal En Gad , Salman Avestimehr , Antonio Ortega

The selection of features is an essential data preprocessing stage in data mining. The core principle of feature selection seems to be to pick a subset of possible features by excluding features with almost no predictive information as well…

Machine Learning · Computer Science 2020-08-11 Mehrdad Rostami , Kamal Berahmand , Saman Forouzandeh

Hypergraph data are often projected onto a weighted graph by constructing an adjacency matrix whose $(i,j)$ entry counts the number of hyperedges containing both nodes $i$ and $j$. This reduction is computationally convenient, but it can…

Statistics Theory · Mathematics 2026-04-20 Kalle Alaluusua , B. R. Vinay Kumar

Network biology has been successfully used to help reveal complex mechanisms of disease, especially cancer. On the other hand, network biology requires in-depth knowledge to construct disease-specific networks, but our current knowledge is…

Computer Vision and Pattern Recognition · Computer Science 2018-06-18 Sungmin Rhee , Seokjun Seo , Sun Kim

Duplication, whether exact or partial, is a common issue in many datasets. In clinical notes data, duplication (and near duplication) can arise for many reasons, such as the pervasive use of templates, copy-pasting, or notes being generated…

Databases · Computer Science 2017-04-20 Sanjeev Shenoy , Tsung-Ting Kuo , Rodney Gabriel , Julian McAuley , Chun-Nan Hsu

We investigate the widely encountered problem of detecting communities in multiplex networks, such as social networks, with an unknown arbitrary heterogeneous structure. To improve detectability, we propose a generative model that leverages…

Social and Information Networks · Computer Science 2019-11-27 Yuming Huang , Ashkan Panahi , Hamid Krim , Liyi Dai

In this paper a novel hand crafted local quadruple pattern (LQPAT) is proposed for facial image recognition and retrieval. Most of the existing hand-crafted descriptors encodes only a limited number of pixels in the local neighbourhood.…

Computer Vision and Pattern Recognition · Computer Science 2022-01-05 Soumendu Chakraborty , Satish Kumar Singh , Pavan Chakraborty

Simplicial complexes can be viewed as high dimensional generalizations of graphs that explicitly encode multi-way ordered relations between vertices at different resolutions, all at once. This concept is central towards detection of higher…

Machine Learning · Computer Science 2022-07-05 Alexandros Dimitrios Keros , Vidit Nanda , Kartic Subr

Low-dimensional embeddings for data from disparate sources play critical roles in multi-modal machine learning, multimedia information retrieval, and bioinformatics. In this paper, we propose a supervised dimensionality reduction method…

Machine Learning · Computer Science 2021-01-15 Yanjun Li , Bihan Wen , Hao Cheng , Yoram Bresler

The neighborhood complex of a graph was introduced by Lov\'asz to provide topological lower bounds on chromatic number. More general homomorphism complexes of graphs were further studied by Babson and Kozlov. Such `Hom complexes' are also…

Combinatorics · Mathematics 2023-08-16 Anton Dochtermann , Anurag Singh

In this paper, we introduce a generalization of graphlets to heterogeneous networks called typed graphlets. Informally, typed graphlets are small typed induced subgraphs. Typed graphlets generalize graphlets to rich heterogeneous networks…

Social and Information Networks · Computer Science 2020-10-28 Ryan A. Rossi , Nesreen K. Ahmed , Aldo Carranza , David Arbour , Anup Rao , Sungchul Kim , Eunyee Koh

Clusters of genes that have evolved by repeated segmental duplication present difficult challenges throughout genomic analysis, from sequence assembly to functional analysis. Improved understanding of these clusters is of utmost importance,…

Machine Learning · Computer Science 2010-01-25 Tomáš Vinař , Broňa Brejová , Giltae Song , Adam Siepel

We propose an assembly algorithm {\sc Barnacle} for sequences generated by the clone-based approach. We illustrate our approach by assembling the human genome. Our novel method abandons the original physical-mapping-first framework. As we…

Data Structures and Algorithms · Computer Science 2007-05-23 Vicky Choi , Martin Farach-Colton

The problem of the reconstruction of the large scale density and velocity fields from peculiar velocities surveys is addressed here within a Bayesian framework by means of Hamiltonian Monte Carlo (HMC) sampling. The HAmiltonian Monte carlo…

Cosmology and Nongalactic Astrophysics · Physics 2022-06-01 Aurélien Valade , Yehuda Hoffman , Noam I Libeskind , Romain Graziani

Representing graphs by their homomorphism counts has led to the beautiful theory of homomorphism indistinguishability in recent years. Moreover, homomorphism counts have promising applications in database theory and machine learning, where…

Data Structures and Algorithms · Computer Science 2023-10-16 Jan Böker , Louis Härtel , Nina Runde , Tim Seppelt , Christoph Standke
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