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For years, semantic interoperability standards have sought to streamline the exchange of clinical data, yet their deployment remains time-consuming, resource-intensive, and technically challenging. To address this, we introduce a…

Computation and Language · Computer Science 2025-07-08 Alvaro Riquelme , Pedro Costa , Catalina Martinez

Healthcare interoperability between openEHR and HL7 FHIR remains challenging due to fundamental differences in their data modeling approaches and the absence of standardized transformation mechanisms. This paper presents FHIRconnect, a…

The Fast Healthcare Interoperability Resources (FHIR) standard has emerged as a widely adopted specification for exchanging structured clinical data across healthcare systems. However, raw FHIR resources are often complex, verbose, and…

Human-Computer Interaction · Computer Science 2026-05-26 Adarsh Pawar , Yuqiao Meng , Luoxi Tang , Zhaohan Xi

Electronic Health Record Systems (EHR-S) are commonly developed in monolithic architectures. This architectural style presents greater complexity and demands more effort when we think of interoperability. A solution proposal is the creation…

This review underscores the vital role of interoperability in digital health, advocating for a standardized framework. It focuses on implementing a Fast Healthcare Interoperability Resources (FHIR) server, addressing technical, semantic,…

Computers and Society · Computer Science 2024-02-06 Prabath Jayathissa , Roshan Hewapathirana

Enhancing clinical decision support (CDS), reducing documentation burdens, and improving patient health literacy remain persistent challenges in digital health. This paper presents an open-source, agent-based framework that integrates Large…

Software Engineering · Computer Science 2025-06-18 Abul Ehtesham , Aditi Singh , Saket Kumar

For clinical data integration and healthcare services, the HL7 FHIR standard has established itself as a desirable format for interoperability between complex health data. Previous attempts at automating the translation from free-form…

Computation and Language · Computer Science 2026-04-21 Johann Frei , Nils Feldhus , Lisa Raithel , Roland Roller , Alexander Meyer , Frank Kramer

Objective: To enhance health literacy and accessibility of health information for a diverse patient population by developing a patient-centered artificial intelligence (AI) solution using large language models (LLMs) and Fast Healthcare…

Computers and Society · Computer Science 2024-02-06 Paul Schmiedmayer , Adrit Rao , Philipp Zagar , Vishnu Ravi , Aydin Zahedivash , Arash Fereydooni , Oliver Aalami

Clinicians routinely navigate fragmented electronic health record (EHR) interfaces to assemble a coherent picture of a patient's problems, medications, recent encounters, and longitudinal trends. This manuscript describes EHRSummarizer, a…

Computation and Language · Computer Science 2026-05-27 Houman Kazemzadeh , Nima Minaifar , Kamyar Naderi , Sho Tabibzadeh

In the past decade, the healthcare industry has made significant advances in the digitization of patient information. However, a lack of interoperability among healthcare systems still imposes a high cost to patients, hospitals, and…

Information Retrieval · Computer Science 2019-12-03 Daniel Cotter , V. K. Cody Bumgardner

The recent shift toward the Health Level Seven Fast Healthcare Interoperability Resources (HL7 FHIR) standard opens a new frontier for clinical AI, demanding LLM agents to navigate complex, resource-based data models instead of conventional…

Computation and Language · Computer Science 2025-11-14 Gyubok Lee , Elea Bach , Eric Yang , Tom Pollard , Alistair Johnson , Edward Choi , Yugang jia , Jong Ha Lee

Data integration among various stakeholders in the healthcare space remains a challenge, despite the impressive advances in Health AI in the past decade. There is a lot of ``messy'' non-standard but structured data that are continually…

Other Computer Science · Computer Science 2026-03-03 Oshani Seneviratne , Manan Shukla , Jianjing Lin

In a healthcare environment, the healthcare interoperability platforms based on HL7 FHIR allow concurrent, asynchronous access to a set of shared patient resources, which are independent systems, i.e., EHR systems, pharmacy systems, lab…

Cryptography and Security · Computer Science 2026-04-06 Jawad Mohammed , Gahangir Hossain

The increasing adoption of digital health technologies has amplified the need for robust, interoperable solutions to manage complex healthcare data. We present the Spezi Data Pipeline, an open-source Python toolkit designed to streamline…

Predictive modeling with electronic health record (EHR) data is anticipated to drive personalized medicine and improve healthcare quality. Constructing predictive statistical models typically requires extraction of curated predictor…

Fast Healthcare Interoperability Resources (FHIR) is the dominant standard for interoperable exchange of healthcare data. In FHIR, electronic health records form a directed graph of resources. Answering clinically meaningful questions over…

Machine Learning · Computer Science 2026-05-15 Marius S. Knorr , Robert Müller , Jan P. Bremer , Nils Schweingruber

In this study, we investigated the ability of the large language model (LLM) to enhance healthcare data interoperability. We leveraged the LLM to convert clinical texts into their corresponding FHIR resources. Our experiments, conducted on…

Computation and Language · Computer Science 2023-10-23 Yikuan Li , Hanyin Wang , Halid Yerebakan , Yoshihisa Shinagawa , Yuan Luo

Despite the growing availability of Electronic Health Record (EHR) data, researchers often face substantial barriers in effectively using these data for translational research due to their complexity, heterogeneity, and lack of standardized…

Electronic Health Records (EHRs) store sensitive patient information, necessitating stringent access control and sharing mechanisms to uphold data security and comply with privacy regulations such as the General Data Protection Regulation…

Cryptography and Security · Computer Science 2026-02-25 Tayeb Kenaza , Islam Debicha , Youcef Fares , Mehdi Sehaki , Sami Messai

Secure and scalable data sharing is essential for collaborative clinical decision making. Conventional clinical data efforts are often siloed, however, which creates barriers to efficient information exchange and impedes effective treatment…

Computers and Society · Computer Science 2018-07-11 Peng Zhang , Jules White , Douglas C. Schmidt , Gunther Lenz , S. Trent Rosenbloom
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