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The carbonic anhydrase II enzyme (CA II) is one of the most significant enzymes in nature, reversibly converting CO$_2$ to bicarbonate at a remarkable rate. The precise mechanism it uses to achieve this rapid turnover remains unclear due to…

Biomolecules · Quantitative Biology 2025-03-19 Timothy T. Duignan

Solid-state electro-aerodynamic propulsion systems are devices that utilize atmospheric pressure corona discharge and have been actively researched in recent years as a means of achieving silent drones. However, these systems contain…

Plasma Physics · Physics 2025-03-31 Hisaichi Shibata , Soya Shimizu , Takahiro Nozaki

The accurate description of large molecular systems in complex environments remains an ongoing challenge for the field of computational chemistry. This problem is even more pronounced for photo-induced processes, as multiple excited…

The solid acids CsH$_2$PO$_4$ and Cs$_7$(H$_4$PO$_4$)(H$_2$PO$_4$)$_8$ pose significant challenges for the simulation of proton transport phenomena. In this work, we use the recently developed machine-learned force field (MLFF) MACE to…

The transport of excess protons and hydroxide ions in water underlies numerous important chemical and biological processes. Accurately simulating the associated transport mechanisms ideally requires utilizing ab initio molecular dynamics…

Chemical Physics · Physics 2023-08-15 Austin O. Atsango , Tobias Morawietz , Ondrej Marsalek , Thomas E. Markland

We examine charge transport through a system of three sites connected in series in the situation when an oscillating charged piston modulates the energy of the middle site. We show that with an appropriate set of parameters, charge can be…

Biological Physics · Physics 2015-04-03 D. Kaur , I. Filonenko , L. Mourokh

Molecular dynamics simulations have been performed on pure liquid water, aqueous solutions of sodium chloride, and polymer solutions exposed to a strong external electric field with the goal to gain molecular insight into the structural…

Soft Condensed Matter · Physics 2016-08-08 I. Nezbeda , J. Jirsák , F. Moučka , W. R. Smith

The primary target of this paper is to present novel compounds in view of their possible use as oxidizers in propulsion applications using molecular modeling calculations and supersonic flow simulations. Carbon-based heterocyclic compounds…

High Energy Physics - Experiment · Physics 2022-03-23 Pujan Biswas , Sudarshan Kumar , Neeraj Kumbhakarna

Mitochondrial adenine nucleotide (AdN) content is regulated through the Ca2+-activated, electroneutral ATP-Mg/Pi carrier (APC). The APC is a protein in the mitochondrial carrier super family that localizes to the inner mitochondrial…

Cell Behavior · Quantitative Biology 2013-04-10 Shivendra G. Tewari , Ranjan K. Dash , Daniel A. Beard , Jason N. Bazil

Nano-scale fluid transport has vast applications spanning from water desalination to biotechnology [1,2]. It is possible to pump fluids in nano-conduits using pressure gradients [3], thermal methods [4], electric [5,6] and magnetic fields…

Mesoscale and Nanoscale Physics · Physics 2019-01-09 Yigit Akkus , Ali Beskok

FoF1-ATP synthase is the enzyme that provides the 'chemical energy currency' adenosine triphosphate, ATP, for living cells. The formation of ATP is accomplished by a stepwise internal rotation of subunits within the enzyme. Briefly, proton…

Biomolecules · Quantitative Biology 2009-11-13 N. Zarrabi , S. Ernst , M. G. Dueser , A. Golovina-Leiker , W. Becker , R. Erdmann , S. D. Dunn , M. Borsch

This study employed an artificial intelligence-enhanced molecular simulation framework to enable efficient Path Integral Molecular Dynamics (PIMD) simulations. Owing to its modular architecture and high-throughput capabilities, the…

Chemical Physics · Physics 2025-04-01 Cheng Fan , Maodong Li , Sihao Yuan , Zhaoxin Xie , Dechin Chen , Yi Isaac Yang , Yi Qin Gao

The most important factor for quantitative results in molecular dynamics simulation are well developed force fields and models. In the present work, the development of new models and the usage of force fields from the literature in large…

Computational Physics · Physics 2010-05-25 Jonathan Walter , Thorsten Merker , Martin Horsch , Jadran Vrabec , Hans Hasse

Manganese(II) mobilised by mining activity poses a persistent water-quality challenge, yet the mechanisms by which low-cost sorbents, such as biochar, sequester Mn(II) remain poorly resolved. This study identifies the specific chemical…

We have developed molecular dynamics codes for a short-range interaction potential that adopt both the flat-MPI and MPI/OpenMP hybrid parallelizations on the basis of a full domain decomposition strategy. Benchmark simulations involving up…

Computational Physics · Physics 2013-11-28 Hiroshi Watanabe , Masaru Suzuki , Nobuyasu Ito

We study ionic liquids composed 1-alkyl-3-methylimidazolium cations and bis(trifluoromethyl-sulfonyl)imide anions ([C$_n$MIm][NTf$_2$]) with varying chain-length $n\!=\!2, 4, 6, 8$ by using molecular dynamics simulations. We show that a…

Soft Condensed Matter · Physics 2017-11-13 Benjamin Golub , Jan Neumann , Lisa-Marie Odebrecht , Ralf Ludwig , Dietmar Paschek

Controlled charge pumping in an AlGaAs/GaAs gated nanowire by single-parameter modulation is studied experimentally and theoretically. Transfer of integral multiples of the elementary charge per modulation cycle is clearly demonstrated. A…

Mesoscale and Nanoscale Physics · Physics 2008-04-15 B. Kaestner , V. Kashcheyevs , S. Amakawa , L. Li , M. D. Blumenthal , T. J. B. M. Janssen , G. Hein , K. Pierz , T. Weimann , U. Siegner , H. W. Schumacher

This paper reviews Irradiation Driven Molecular Dynamics (IDMD) - a novel computational methodology for atomistic simulations of the irradiation driven transformations of complex molecular systems implemented in the MBN Explorer software…

Chemical Physics · Physics 2023-09-06 Alexey V. Verkhovtsev , Ilia A. Solov'yov , Andrey V. Solov'yov

Efficient computational methods that are capable of supporting experimental measures obtained at constant values of pH and redox potential are important tools as they serve to, among other things, provide additional atomic level information…

Chemical Physics · Physics 2018-09-21 Vinícius Wilian D. Cruzeiro , Adrian E. Roitberg

We analyze one of the simplest active suspensions with complex dynamics: a suspension of immotile "Extensor" particles that exert active extensile dipolar stresses on the fluid in which they are immersed. This is relevant to several…

Soft Condensed Matter · Physics 2017-09-18 Tong Gao , Meredith D. Betterton , An-Sheng Jhang , Michael J. Shelley