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Automatic detection and segmentation of cells and nuclei in microscopy images is important for many biological applications. Recent successful learning-based approaches include per-pixel cell segmentation with subsequent pixel grouping, or…

Computer Vision and Pattern Recognition · Computer Science 2018-11-09 Uwe Schmidt , Martin Weigert , Coleman Broaddus , Gene Myers

Early detection and segmentation of skin lesions is crucial for timely diagnosis and treatment, necessary to improve the survival rate of patients. However, manual delineation is time consuming and subject to intra- and inter-observer…

Computer Vision and Pattern Recognition · Computer Science 2019-02-26 Sulaiman Vesal , Shreyas Malakarjun Patil , Nishant Ravikumar , Andreas Maier

In this article, we look into some essential aspects of convolutional neural networks (CNNs) with the focus on medical image segmentation. First, we discuss the CNN architecture, thereby highlighting the spatial origin of the data,…

Computer Vision and Pattern Recognition · Computer Science 2022-11-18 Jeroen Bertels , David Robben , Robin Lemmens , Dirk Vandermeulen

Deep cerebellar nuclei are a key structure of the cerebellum that are involved in processing motor and sensory information. It is thus a crucial step to accurately segment deep cerebellar nuclei for the understanding of the cerebellum…

Image and Video Processing · Electrical Eng. & Systems 2020-06-02 Jinyoung Kim , Remi Patriat , Jordan Kaplan , Oren Solomon , Noam Harel

The automated analysis of microscopy images is a challenge in the context of single-cell tracking and quantification. This work has as goals the study of the performance of deep learning for segmenting microscopy images and the improvement…

Quantitative Methods · Quantitative Biology 2022-10-05 André O. Françani

We consider the problem of accurately identifying cell boundaries and labeling individual cells in confocal microscopy images, specifically, 3D image stacks of cells with tagged cell membranes. Precise identification of cell boundaries,…

Computer Vision and Pattern Recognition · Computer Science 2019-09-06 Jiaxiang Jiang , Po-Yu Kao , Samuel A. Belteton , Daniel B. Szymanski , B. S. Manjunath

Three-dimensional volumetric imaging of cells allows for in situ visualization, thus preserving contextual insights into cellular processes. Despite recent advances in machine learning methods, morphological analysis of sub-nuclear…

Quantitative Methods · Quantitative Biology 2022-07-21 Niraj Gupta , Eric J. Roberts , Song Pang , C. Shan Xu , Harald F. Hess , Fan Wu , Abby Dernburg , Danielle Jorgens , Petrus H. Zwart , Vignesh Kasinath

Every year millions of people die due to disease of Cancer. Due to its invasive nature it is very complex to cure even in primary stages. Hence, only method to survive this disease completely is via forecasting by analyzing the early…

Computer Vision and Pattern Recognition · Computer Science 2018-08-24 Shivam Singh , Stuti Pathak

Deep convolutional neural networks have been proven to be very effective in image related analysis and tasks, such as image segmentation, image classification, image generation, etc. Recently many sophisticated CNN based architectures have…

Image and Video Processing · Electrical Eng. & Systems 2020-05-12 Eshal Zahra , Bostan Ali , Wajahat Siddique

Fluorescence microscopy is an essential tool for the analysis of 3D subcellular structures in tissue. An important step in the characterization of tissue involves nuclei segmentation. In this paper, a two-stage method for segmentation of…

Image and Video Processing · Electrical Eng. & Systems 2020-01-10 David Joon Ho , Shuo Han , Chichen Fu , Paul Salama , Kenneth W. Dunn , Edward J. Delp

Early diagnosis is essential for the successful treatment of bowel cancers including colorectal cancer (CRC) and capsule endoscopic imaging with robotic actuation can be a valuable diagnostic tool when combined with automated image…

Automatic cell detection in histology images is a challenging task due to varying size, shape and features of cells and stain variations across a large cohort. Conventional deep learning methods regress the probability of each pixel…

Computer Vision and Pattern Recognition · Computer Science 2018-06-20 Shan E Ahmed Raza , Khalid AbdulJabbar , Mariam Jamal-Hanjani , Selvaraju Veeriah , John Le Quesne , Charles Swanton , Yinyin Yuan

Accurate detection and classification of nuclei in histopathology images are critical for diagnostic and research applications. We present KongNet, a multi-headed deep learning architecture featuring a shared encoder and parallel,…

Image and Video Processing · Electrical Eng. & Systems 2026-05-13 Jiaqi Lv , Esha Sadia Nasir , Kesi Xu , Mostafa Jahanifar , Brinder Singh Chohan , Behnaz Elhaminia , Shan E Ahmed Raza

Deep convolutional neural networks (DCNNs) have become the state-of-the-art computational models of biological object recognition. Their remarkable success has helped vision science break new ground and recent efforts have started to…

Computer Vision and Pattern Recognition · Computer Science 2023-08-22 Leonard E. van Dyck , Walter R. Gruber

Detection of cell nuclei in microscopic images is a challenging research topic, because of limitations in cellular image quality and diversity of nuclear morphology, i.e. varying nuclei shapes, sizes, and overlaps between multiple cell…

Computer Vision and Pattern Recognition · Computer Science 2018-07-10 Mohammad Tofighi , Tiantong Guo , Jairam K. P. Vanamala , Vishal Monga

Ultrasound scanning is essential in several medical diagnostic and therapeutic applications. It is used to visualize and analyze anatomical features and structures that influence treatment plans. However, it is both labor intensive, and its…

Computer Vision and Pattern Recognition · Computer Science 2021-06-29 Abdullah F. Al-Battal , Yan Gong , Lu Xu , Timothy Morton , Chen Du , Yifeng Bu 1 , Imanuel R Lerman , Radhika Madhavan , Truong Q. Nguyen

Accurate and robust cell nuclei classification is the cornerstone for a wider range of tasks in digital and Computational Pathology. However, most machine learning systems require extensive labeling from expert pathologists for each…

Quantitative Methods · Quantitative Biology 2016-12-05 Stefan Bauer , Nicolas Carion , Peter Schüffler , Thomas Fuchs , Peter Wild , Joachim M. Buhmann

The ability to automatically detect certain types of cells or cellular subunits in microscopy images is of significant interest to a wide range of biomedical research and clinical practices. Cell detection methods have evolved from…

Computer Vision and Pattern Recognition · Computer Science 2018-02-22 Yao Xue , Nilanjan Ray

Automated detection of curvilinear structures, e.g., blood vessels or nerve fibres, from medical and biomedical images is a crucial early step in automatic image interpretation associated to the management of many diseases. Precise…

Image and Video Processing · Electrical Eng. & Systems 2020-10-20 Lei Mou , Yitian Zhao , Huazhu Fu , Yonghuai Liu , Jun Cheng , Yalin Zheng , Pan Su , Jianlong Yang , Li Chen , Alejandro F Frang , Masahiro Akiba , Jiang Liu

Past few years have witnessed exponential growth of interest in deep learning methodologies with rapidly improving accuracies and reduced computational complexity. In particular, architectures using Convolutional Neural Networks (CNNs) have…

Computer Vision and Pattern Recognition · Computer Science 2018-05-11 Sai Samarth R Phaye , Apoorva Sikka , Abhinav Dhall , Deepti Bathula