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Mammograms are commonly employed in the large scale screening of breast cancer which is primarily characterized by the presence of malignant masses. However, automated image-level detection of malignancy is a challenging task given the…

Computer Vision and Pattern Recognition · Computer Science 2020-04-27 Sarath Chandra K , Arunava Chakravarty , Nirmalya Ghosh , Tandra Sarkar , Ramanathan Sethuraman , Debdoot Sheet

Digital histopathology whole slide images (WSIs) provide gigapixel-scale high-resolution images that are highly useful for disease diagnosis. However, digital histopathology image analysis faces significant challenges due to the limited…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Bodong Zhang , Xiwen Li , Hamid Manoochehri , Xiaoya Tang , Deepika Sirohi , Beatrice S. Knudsen , Tolga Tasdizen

Cancer diagnosis has greatly benefited from the integration of whole-slide images (WSIs) with multiple instance learning (MIL), enabling high-resolution analysis of tissue morphology. Graph-based MIL (GNN-MIL) approaches have emerged as…

Computer Vision and Pattern Recognition · Computer Science 2025-08-27 Jongwoo Kim , Bryan Wong , Huazhu Fu , Willmer Rafell Quiñones , Youngsin Ko , Mun Yong Yi

Convolutional neural networks can be trained to perform histology slide classification using weak annotations with multiple instance learning (MIL). However, given the paucity of labeled histology data, direct application of MIL can easily…

Computer Vision and Pattern Recognition · Computer Science 2019-11-05 Ming Y. Lu , Richard J. Chen , Jingwen Wang , Debora Dillon , Faisal Mahmood

Multiple Instance Learning (MIL) plays a significant role in computational pathology, enabling weakly supervised analysis of Whole Slide Image (WSI) datasets. The field of WSI analysis is confronted with a severe long-tailed distribution…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Xitong Ling , Yifeng Ping , Jiawen Li , Jing Peng , Yuxuan Chen , Minxi Ouyang , Yizhi Wang , Yonghong He , Tian Guan , Xiaoping Liu , Lianghui Zhu

Whole slide image (WSI) refers to a type of high-resolution scanned tissue image, which is extensively employed in computer-assisted diagnosis (CAD). The extremely high resolution and limited availability of region-level annotations make…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Ruijie Zhang , Qiaozhe Zhang , Yingzhuang Liu , Hao Xin , Yan Liu , Xinggang Wang

Multiple Instance Learning (MIL) is a weakly supervised learning problem where the aim is to assign labels to sets or bags of instances, as opposed to traditional supervised learning where each instance is assumed to be independent and…

Machine Learning · Computer Science 2022-02-24 Soumyasundar Pal , Antonios Valkanas , Florence Regol , Mark Coates

We address the challenging problem of whole slide image (WSI) classification. WSIs have very high resolutions and usually lack localized annotations. WSI classification can be cast as a multiple instance learning (MIL) problem when only…

Computer Vision and Pattern Recognition · Computer Science 2021-04-05 Bin Li , Yin Li , Kevin W. Eliceiri

We address the problem of \emph{instance label stability} in multiple instance learning (MIL) classifiers. These classifiers are trained only on globally annotated images (bags), but often can provide fine-grained annotations for image…

Computer Vision and Pattern Recognition · Computer Science 2017-03-16 Veronika Cheplygina , Lauge Sørensen , David M. J. Tax , Marleen de Bruijne , Marco Loog

Multiple-instance learning (MIL) is a paradigm of machine learning that aims to classify a set (bag) of objects (instances), assigning labels only to the bags. This problem is often addressed by selecting an instance to represent each bag,…

Human-Computer Interaction · Computer Science 2021-12-22 Sonia Castelo , Moacir Ponti , Rosane Minghim

In recent years, the integration of pre-trained foundational models with multiple instance learning (MIL) has improved diagnostic accuracy in computational pathology. However, existing MIL methods focus on optimizing feature extractors and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-24 Le Feng , Li Xiao

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Modern machine learning pipelines, in particular those based on deep learning (DL) models, require large amounts of labeled data. For classification problems, the most common learning paradigm consists of presenting labeled examples during…

Computer Vision and Pattern Recognition · Computer Science 2022-11-30 Jacopo Teneggi , Paul H. Yi , Jeremias Sulam

Multi-instance learning (MIL) has a wide range of applications due to its distinctive characteristics. Although many state-of-the-art algorithms have achieved decent performances, a plurality of existing methods solve the problem only in…

Machine Learning · Statistics 2015-12-04 Hanqiang Song , Zhuotun Zhu , Xinggang Wang

Multiple Instance Learning (MIL) methods have become increasingly popular for classifying giga-pixel sized Whole-Slide Images (WSIs) in digital pathology. Most MIL methods operate at a single WSI magnification, by processing all the tissue…

Computer Vision and Pattern Recognition · Computer Science 2022-07-27 Kevin Thandiackal , Boqi Chen , Pushpak Pati , Guillaume Jaume , Drew F. K. Williamson , Maria Gabrani , Orcun Goksel

Histopathology image analysis can be considered as a Multiple instance learning (MIL) problem, where the whole slide histopathology image (WSI) is regarded as a bag of instances (i.e, patches) and the task is to predict a single class label…

Computer Vision and Pattern Recognition · Computer Science 2019-06-28 Meng Li , Lin Wu , Arnold Wiliem , Kun Zhao , Teng Zhang , Brian C. Lovell

Deep learning for medical image classification faces three major challenges: 1) the number of annotated medical images for training are usually small; 2) regions of interest (ROIs) are relatively small with unclear boundaries in the whole…

Computer Vision and Pattern Recognition · Computer Science 2019-10-23 Shaohua Li , Yong Liu , Xiuchao Sui , Cheng Chen , Gabriel Tjio , Daniel Shu Wei Ting , Rick Siow Mong Goh

Transfer learning from large-scale pre-trained models has become essential for many computer vision tasks. Recent studies have shown that datasets like ImageNet are weakly labeled since images with multiple object classes present are…

Computer Vision and Pattern Recognition · Computer Science 2021-11-25 Sai Rajeswar , Pau Rodriguez , Soumye Singhal , David Vazquez , Aaron Courville

Of late, weakly supervised object detection is with great importance in object recognition. Based on deep learning, weakly supervised detectors have achieved many promising results. However, compared with fully supervised detection, it is…

Computer Vision and Pattern Recognition · Computer Science 2017-04-04 Peng Tang , Xinggang Wang , Xiang Bai , Wenyu Liu

Identifying unique polyps in colon capsule endoscopy (CCE) images is a critical yet challenging task for medical personnel due to the large volume of images, the cognitive load it creates for clinicians, and the ambiguity in labeling…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Puneet Sharma , Kristian Dalsbø Hindberg , Eibe Frank , Benedicte Schelde-Olesen , Ulrik Deding
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