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The performance of Emergency Departments (EDs) is of great importance for any health care system, as they serve as the entry point for many patients. However, among other factors, the variability of patient acuity levels and corresponding…
Mobile medical units (MMUs) are customized vehicles fitted with medical equipment that are used to provide primary care in rural environments. As MMUs can be easily relocated, they enable a demand-oriented, flexible, and local provision of…
Time-to-event endpoints are central to evaluate treatment efficacy across many disease areas. Many trial protocols include interim analyses within group-sequential designs that control type I error via spending functions or boundary…
We consider a stochastic bipartite matching model consisting of multi-class customers and multi-class servers. Compatibility constraints between the customer and server classes are described by a bipartite graph. Each time slot, exactly one…
Operations Research approaches to surgical scheduling are becoming increasingly popular in both theory and practice. Often these models neglect stochasticity in order to reduce the computational complexity of the problem. We wish to provide…
Ambulance demand estimation at fine time and location scales is critical for fleet management and dynamic deployment. We are motivated by the problem of estimating the spatial distribution of ambulance demand in Toronto, Canada, as it…
Line planning in public transport is the strategic problem of selecting lines and their operating frequencies. This problem is important as it defines the passenger service, based on available connections and expected travel times, and…
In the Home Service Assignment, Routing, and Appointment scheduling (H-SARA) problem, a set of homogeneous service teams must visit a set of customers. The home service provider needs to decide how many teams to hire (i.e., sizing problem),…
In this paper, we propose an approximate dynamic programming (ADP) algorithm to solve a Markov decision process (MDP) formulation for the admission control of elective patients. To manage the elective patients from multiple specialties…
We consider the problem of scheduling elective surgeries in a Children's Hospital, where disruptions due to emergencies and no-shows may arise. We account for two features that occur in many pediatric settings: i) that it is not uncommon…
Effective patient queue management to minimize patient wait delays and patient overcrowding is one of the major challenges faced by hospitals. Unnecessary and annoying waits for long periods result in substantial human resource and time…
Pragmatic trials increasingly define outcomes using real-world data such as electronic health records, where assessments are collected during routine care rather than at fixed timepoints. Consequently, these uncontrolled assessments may be…
Medical emergency departments are complex systems in which patients must be treated according to priority rules based on the severity of their condition. We develop a model of emergency departments using Petri nets with priorities,…
Motivated by the operational problems in click and collect systems, such as curbside pickup programs, we study a joint admission control and capacity allocation problem. We consider a system where arriving customers have preferred service…
Two useful strategies to speed up drug development are to increase the patient accrual rate and use novel adaptive designs. Unfortunately, these two strategies often conflict when the evaluation of the outcome cannot keep pace with the…
In intelligent transportation systems (ITS), adaptive transit signal priority (TSP) and dynamic bus control systems have been independently developed to maintain efficient and reliable urban bus services. However, those two systems could…
The study of stable matchings usually relies on the assumption that agents' preferences over the opposite side are complete and known. In many real markets, however, preferences might be uncertain and revealed only through costly…
Machine learning for data-driven diagnosis has been actively studied in medicine to provide better healthcare. Supporting analysis of a patient cohort similar to a patient under treatment is a key task for clinicians to make decisions with…
A queue is required when a service provider is not able to handle jobs arriving over the time. In a highly flexible and dynamic environment, some jobs might demand for faster execution at run-time especially when the resources are limited…
This paper addresses a production scheduling problem derived from an industrial use case, focusing on unrelated parallel machine scheduling with the personnel availability constraint. The proposed model optimizes the production plan over a…