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We study the problem of estimating the parameters of a regression model from a set of observations, each consisting of a response and a predictor. The response is assumed to be related to the predictor via a regression model of unknown…

Machine Learning · Statistics 2016-05-19 Carlos Alberto Gomez-Uribe

We derive an asymptotic expansion for the log likelihood of Gaussian mixture models (GMMs) with equal covariance matrices in the low signal-to-noise regime. The expansion reveals an intimate connection between two types of algorithms for…

Statistics Theory · Mathematics 2020-06-30 Anya Katsevich , Afonso Bandeira

Deep learning has emerged as the preferred modeling approach for automatic ECG analysis. In this study, we investigate three elements aimed at improving the quantitative accuracy of such systems. These components consistently enhance…

Signal Processing · Electrical Eng. & Systems 2023-08-30 Temesgen Mehari , Nils Strodthoff

We revisit data selection in a modern context of finetuning from a fundamental perspective. Extending the classical wisdom of variance minimization in low dimensions to high-dimensional finetuning, our generalization analysis unveils the…

Machine Learning · Computer Science 2025-02-10 Yijun Dong , Hoang Phan , Xiang Pan , Qi Lei

Momentum methods have been shown to accelerate the convergence of the standard gradient descent algorithm in practice and theory. In particular, the minibatch-based gradient descent methods with momentum (MGDM) are widely used to solve…

Methodology · Statistics 2022-11-29 Yuan Gao , Xuening Zhu , Haobo Qi , Guodong Li , Riquan Zhang , Hansheng Wang

Many modern time-series datasets contain large numbers of output response variables sampled for prolonged periods of time. For example, in neuroscience, the activities of 100s-1000's of neurons are recorded during behaviors and in response…

Machine Learning · Computer Science 2022-03-15 Rui Meng , Kristofer Bouchard

The recent interest in human dynamics has led researchers to investigate the stochastic processes that explain human behaviour in various contexts. Here we propose a generative model to capture the dynamics of survival analysis,…

Physics and Society · Physics 2015-09-30 Trevor Fenner , Mark Levene , George Loizou

This paper develops theory for feasible estimators of finite-dimensional parameters identified by general conditional quantile restrictions, under much weaker assumptions than previously seen in the literature. This includes instrumental…

Statistics Theory · Mathematics 2021-10-07 Luciano de Castro , Antonio F. Galvao , David M. Kaplan , Xin Liu

A valuable step in the modeling of multiscale dynamical systems in fields such as computational chemistry, biology, materials science and more, is the representative sampling of the phase space over long timescales of interest; this task is…

Machine Learning · Computer Science 2023-12-29 Ellis R. Crabtree , Juan M. Bello-Rivas , Ioannis G. Kevrekidis

The presence of protein aggregates in cells is a known feature of many human age-related diseases, such as Huntington's disease. Simulations using fixed parameter values in a model of the dynamic evolution of expanded polyglutamine (PolyQ)…

Markov models of character substitution on phylogenies form the foundation of phylogenetic inference frameworks. Early models made the simplifying assumption that the substitution process is homogeneous over time and across sites in the…

Populations and Evolution · Quantitative Biology 2019-06-13 Guy Baele , Mandev S. Gill , Philippe Lemey , Marc A. Suchard

A generalized Gaussian process model (GGPM) is a unifying framework that encompasses many existing Gaussian process (GP) models, such as GP regression, classification, and counting. In the GGPM framework, the observation likelihood of the…

Machine Learning · Statistics 2013-11-28 Lifeng Shang , Antoni B. Chan

We consider distributed estimation of the inverse covariance matrix, also called the concentration or precision matrix, in Gaussian graphical models. Traditional centralized estimation often requires global inference of the covariance…

Machine Learning · Statistics 2015-06-15 Zhaoshi Meng , Dennis Wei , Ami Wiesel , Alfred O. Hero

Accurate estimation of production times is critical for effective manufacturing scheduling, yet traditional methods relying on expert analysis or historical data often fall short in dynamic or customized production environments. This paper…

Machine Learning · Computer Science 2025-09-05 Grzegorz Miebs , Rafał A. Bachorz

Large-scale statistical analysis of data sets associated with genome sequences plays an important role in modern biology. A key component of such statistical analyses is the computation of $p$-values and confidence bounds for statistics…

Applications · Statistics 2011-01-06 Peter J. Bickel , Nathan Boley , James B. Brown , Haiyan Huang , Nancy R. Zhang

Identifying differentially methylated cytosine-guanine dinucleotide (CpG) sites between benign and tumour samples can assist in understanding disease. However, differential analysis of bounded DNA methylation data often requires data…

Autoregressive models capture stochastic processes in which past realizations determine the generative distribution of new data; they arise naturally in a variety of industrial, biomedical, and financial settings. A key challenge when…

Statistics Theory · Mathematics 2020-07-30 Daren Wang , Yi Yu , Alessandro Rinaldo , Rebecca Willett

Ordinary differential equation models have become a standard tool for the mechanistic description of biochemical processes. If parameters are inferred from experimental data, such mechanistic models can provide accurate predictions about…

Quantitative Methods · Quantitative Biology 2018-10-12 Fabian Fröhlich , Carolin Loos , Jan Hasenauer

This paper proposes a probabilistic motion prediction method for long motions. The motion is predicted so that it accomplishes a task from the initial state observed in the given image. While our method evaluates the task achievability by…

Computer Vision and Pattern Recognition · Computer Science 2024-03-08 Takeru Oba , Norimichi Ukita

In this paper, we discuss computational aspects to obtain accurate inferences for the parameters of the generalized gamma (GG) distribution. Usually, the solution of the maximum likelihood estimators (MLE) for the GG distribution have no…

Computation · Statistics 2017-07-26 Jorge Alberto Achcar , Pedro Luiz Ramos , Edson Zangiacomi Martinez