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Purpose: Microscopic fractional anisotropy ({\mu}FA) can disentangle microstructural information from orientation dispersion. While double diffusion encoding (DDE) MRI methods are widely used to extract accurate {\mu}FA, it has only…

Medical Physics · Physics 2019-03-21 Rafael Neto Henriques , Sune N Jespersen , Noam Shemesh

Microscopic diffusion anisotropy ({\mu}A) has been recently gaining increasing attention for its ability to decouple the average compartment anisotropy from orientation dispersion. Advanced diffusion MRI sequences, such as double diffusion…

Diffusion Magnetic Resonance Imaging (dMRI) is one of the most important contemporary non-invasive modalities for probing tissue structure at the microscopic scale. The majority of dMRI techniques employ standard single diffusion encoding…

Mapping tissue microstructure accurately and noninvasively is one of the frontiers of biomedical imaging. Diffusion Magnetic Resonance Imaging (MRI) is at the forefront of such efforts, as it is capable of reporting on microscopic…

Medical Physics · Physics 2019-03-26 Noam Shemesh

Diffusion anisotropy in diffusion tensor imaging (DTI) is commonly quantified with normalized diffusion anisotropy indices (DAIs). Most often, the fractional anisotropy (FA) is used, but several alternative DAIs have been introduced in…

Brain metabolites, such as N-acetylaspartate or myo-inositol, are constantly probing their local cellular environment under the effect of diffusion. Diffusion-weighted NMR spectroscopy therefore presents unparalleled potential to yield…

Medical Physics · Physics 2019-08-02 Melissa Vincent , Marco Palombo , Julien Valette

Purpose: Biophysical tissue models are increasingly used in the interpretation of diffusion MRI (dMRI) data, with the potential to provide specific biomarkers of brain microstructural changes. However, the general Standard Model has…

Biological Physics · Physics 2019-03-19 Santiago Coelho , Jose M. Pozo , Sune N. Jespersen , Derek K. Jones , Alejandro F. Frangi

Double diffusion encoding (DDE) magnetic resonance measurements of the water signal offers a unique ability to separate the effect of microscopic anisotropic diffusion in structural units of tissue from the overall macroscopic orientational…

Medical Physics · Physics 2020-12-04 Henrik Lundell , Chloé Najac , Marjolein Bulk , Hermien E. Kan , Andrew G. Webb , Itamar Ronen

Purpose: To assess the technical feasibility of whole-brain diffusional variance decomposition (DIVIDE) based on q-space trajectory encoding (QTE) at clinical MRI systems with varying performance. DIVIDE is used to separate diffusional…

Medical Physics · Physics 2019-04-03 Filip Szczepankiewicz , Jens Sjölund , Freddy Ståhlberg , Jimmy Lätt , Markus Nilsson

Purpose: Eddy currents might lead to image distortions in diffusion weighted echo planar imaging. A method is proposed to reduce their effects on double diffusion encoding (DDE) MRI experiments and the thereby derived microscopic fractional…

Medical Physics · Physics 2021-04-20 Lars Mueller , Andreas Wetscherek , Tristan Anselm Kuder , Frederik Bernd Laun

Diffusion-based image generative models produce high-fidelity images through iterative denoising but remain vulnerable to memorization, where they unintentionally reproduce exact copies or parts of training images. Recent memorization…

Machine Learning · Computer Science 2026-02-11 Rohan Asthana , Vasileios Belagiannis

We suggest to utilize the rich information content about microstructural tissue properties entangled in asymmetric balanced steady-state free precession (bSSFP) profiles to estimate multiple diffusion metrics simultaneously by neural…

Anisotropic Diffusion is widely used for noise reduction with simultaneous preservation of vascular structures in maximum intensity projected (MIP) angiograms. However, extension to minimum intensity projected (mIP) venograms in…

Computer Vision and Pattern Recognition · Computer Science 2015-01-15 P. K. Akshara , J. S. Paul

Knowledge of the noise distribution in diffusion MRI is the centerpiece to quantify uncertainties arising from the acquisition process. Accurate estimation beyond textbook distributions often requires information about the acquisition…

Image and Video Processing · Electrical Eng. & Systems 2020-07-07 Samuel St-Jean , Alberto De Luca , Chantal M. W. Tax , Max A. Viergever , Alexander Leemans

Diffusion-weighted magnetic resonance imaging (DW-MRI) is a critical imaging method for capturing and modeling tissue microarchitecture at a millimeter scale. A common practice to model the measured DW-MRI signal is via fiber orientation…

Double diffusion encoding (DDE) makes diffusion MRI sensitive to a wide range of microstructural features, and the acquired data can be analysed using different approaches. Correlation tensor imaging (CTI) uses DDE to resolve three…

Medical Physics · Physics 2024-12-05 Arthur Chakwizira , Filip Szczepankiewicz , Markus Nilsson

Magnetic Resonance Imaging (MRI), including diffusion MRI (dMRI), serves as a ``microscope'' for anatomical structures and routinely mitigates the influence of low signal-to-noise ratio scans by compromising temporal or spatial resolution.…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 Chenxu Wu , Qingpeng Kong , Zihang Jiang , S. Kevin Zhou

Diffusion MRI (dMRI) is essential for studying brain microstructure, but high-resolution imaging remains challenging due to the inherent trade-offs between acquisition time and signal-to-noise ratio (SNR). Conventional methods often…

Image and Video Processing · Electrical Eng. & Systems 2025-05-20 Yinzhe Wu , Jiahao Huang , Fanwen Wang , Mengze Gao , Congyu Liao , Guang Yang , Kawin Setsompop

Diffusion MRI (dMRI) of the developing brain can provide valuable insights into the white matter development. However, slice thickness in fetal dMRI is typically high (i.e., 3-5 mm) to freeze the in-plane motion, which reduces the…

Image and Video Processing · Electrical Eng. & Systems 2022-08-30 Hamza Kebiri , Gabriel Girard , Yasser Aleman-Gomez , Thomas Yu , Andras Jakab , Erick Jorge Canales-Rodriguez , Meritxell Bach Cuadra

Medical image denoising is considered among the most challenging vision tasks. Despite the real-world implications, existing denoising methods have notable drawbacks as they often generate visual artifacts when applied to heterogeneous…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 S M A Sharif , Rizwan Ali Naqvi , Woong-Kee Loh
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