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Biological cells encode information about their environment through biochemical signaling networks that control their internal state and response. This information is often encoded in the dynamical patterns of the signaling molecules,…

Molecular Networks · Quantitative Biology 2023-04-24 Lauritz Hahn , Aleksandra M. Walczak , Thierry Mora

Both action potentials and mechanosensitive signalling are an important communication mechanisms in plants. Considering an information theoretic framework, this paper explores the effective range of multiple action potentials for a long…

Molecular Networks · Quantitative Biology 2019-11-13 Hamdan Awan , Kareem Zeid , Raviraj S. Adve , Nigel Wallbridge , Carrol Plummer , Andrew W. Eckford

We propose an information-theoretic framework for analyzing control systems based on the close relationship of controllers to communication channels. A communication channel takes an input state and transforms it into an output state. A…

Data Analysis, Statistics and Probability · Physics 2007-05-23 Hugo Touchette , Seth Lloyd

Eukaryotic cells are able to sense chemical gradients in a wide range of environments. We show that, if a cell is exposed to a highly variable environment, it may gain chemotactic accuracy by expressing multiple receptor types with varying…

Cell Behavior · Quantitative Biology 2020-11-04 Austin Hopkins , Brian A. Camley

Molecular communication (MC) offers a groundbreaking approach to communication inspired by biological signaling. It is particularly suited for environments where traditional electromagnetic methods fail, such as fluid mediums or within the…

Molecular Networks · Quantitative Biology 2025-03-18 Aravind Muraleedharan , Abhishek K. Gupta

Biological cells are able to accurately sense chemicals with receptors at their surfaces, allowing cells to move towards sources of attractant and away from sources of repellent. The accuracy of sensing chemical concentration is ultimately…

Subcellular Processes · Quantitative Biology 2015-05-14 Robert G. Endres , Ned S. Wingreen

Cellular signaling involves the transmission of environmental information through cascades of stochastic biochemical reactions, inevitably introducing noise that compromises signal fidelity. Each stage of the cascade often takes the form of…

Molecular Networks · Quantitative Biology 2014-08-20 Michael Hinczewski , D. Thirumalai

A path information is defined in connection with the probability distribution of paths of nonequilibrium hamiltonian systems moving in phase space from an initial cell to different final cells. On the basis of the assumption that these…

Statistical Mechanics · Physics 2007-05-23 Q. A. Wang

We develop numerical and analytical approaches to calculate mutual information between complete paths of two molecular components embedded into a larger reaction network. In particular, we focus on a continuous-time Markov chain formalism,…

Molecular Networks · Quantitative Biology 2022-08-09 Anne-Lena Moor , Christoph Zechner

Communication between cells is realized by exchange of biochemical substances. Due to internal organization of living systems and variability of external parameters, the exchange is heavily influenced by perturbations of various parameters…

Chaotic Dynamics · Physics 2015-05-19 Dragutin T. Mihailovic , Igor Balaz

Cellular development follows a stochastic yet rule-governed trajectory, though the underlying principles remain elusive. Here, we propose that cellular development follows paths of least action, aligning with foundational physical laws that…

Biological Physics · Physics 2025-04-14 Rohola Zandie , Farhan Khodaee , Yufan Xia , Elazer R. Edelman

A closer look at nature has recently brought more interest in exploring and utilizing intra-body communication networks composed of cells as intrinsic, perfectly biocompatible infrastructures to deliver therapeutics. Naturally occurring…

Signal Processing · Electrical Eng. & Systems 2022-07-06 Hamid Khoshfekr Rudsari , Mohammad Zoofaghari , Mladen Veletic , Jacob Bergsland , Ilangko Balasingham

Cells in natural environments like tissue or soil sense and respond to extracellular ligands with intricately structured and non-monotonic spatial distributions that are sculpted by processes such as fluid flow and substrate adhesion.…

Cell Behavior · Quantitative Biology 2021-07-05 Zitong Jerry Wang , Matt Thomson

Translation is one of the most fundamental processes in the biological cell. Because of the central role that translation plays across all domains of life, the enzyme that carries out this process, the ribosome, is required to process…

Quantitative Methods · Quantitative Biology 2023-10-11 Daniel A. Inafuku , Kay L. Kirkpatrick , Onyema Osuagwu , Qier An , David A. Brewster , Mayisha Zeb Nakib

The function of the organism hinges on the performance of its information-processing networks, which convey information via molecular recognition. Many paths within these networks utilize molecular codebooks, such as the genetic code, to…

Biomolecules · Quantitative Biology 2010-07-27 Tsvi Tlusty

Living cells are continually exposed to environmental signals that vary in time. These signals are detected and processed by biochemical networks, which are often highly stochastic. To understand how cells cope with a fluctuating…

Molecular Networks · Quantitative Biology 2012-06-01 Wiet de Ronde , Filipe Tostevin , Pieter Rein ten Wolde

For any class of channel conditional distributions, with finite memory dependence on channel input RVs $A^n {\stackrel{\triangle}{=}} \{A_i: i=0, \ldots, n\}$ or channel output RVs $B^n {\stackrel{\triangle}{=}} \{B_i: i=0, \ldots, n\}$ or…

Information Theory · Computer Science 2016-08-22 Charalambos D. Charalambous , Christos K. Kourtellaris

Inspired by findings of sensorimotor coupling in humans and animals, there has recently been a growing interest in the interaction between action and perception in robotic systems [Bogh et al., 2016]. Here we consider perception and action…

Artificial Intelligence · Computer Science 2018-04-18 Zhen Peng , Tim Genewein , Felix Leibfried , Daniel A. Braun

In diffusion-based molecular communications, messages can be conveyed via the variation in the concentration of molecules in the medium. In this paper, we intend to analyze the achievable capacity in transmission of information from one…

Information Theory · Computer Science 2011-05-11 Arash Einolghozati , Mohsen Sardari , Ahmad Beirami , Faramarz Fekri

Hybrid models of chemotaxis combine agent-based models of cells with partial differential equation models of extracellular chemical signals. In this paper, travelling wave properties of hybrid models of bacterial chemotaxis are…

Biological Physics · Physics 2013-02-13 Benjamin Franz , Chuan Xue , Kevin J. Painter , Radek Erban