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Inferring Gene Regulatory Networks (GRNs) from gene expression data is crucial for understanding biological processes. While supervised models are reported to achieve high performance for this task, they rely on costly ground truth (GT)…

Machine Learning · Statistics 2025-06-10 Tianyu Cui , Song-Jun Xu , Artem Moskalev , Shuwei Li , Tommaso Mansi , Mangal Prakash , Rui Liao

We apply Bayesian Additive Regression Tree (BART) principles to training an ensemble of small neural networks for regression tasks. Using Markov Chain Monte Carlo, we sample from the posterior distribution of neural networks that have a…

Machine Learning · Statistics 2024-04-09 Danielle Van Boxel

Recurrent neural networks (RNNs) have recently achieved remarkable successes in a number of applications. However, the huge sizes and computational burden of these models make it difficult for their deployment on edge devices. A practically…

Machine Learning · Computer Science 2019-12-10 Liangjian Wen , Xuanyang Zhang , Haoli Bai , Zenglin Xu

Gene expression-based heterogeneity analysis has been extensively conducted. In recent studies, it has been shown that network-based analysis, which takes a system perspective and accommodates the interconnections among genes, can be more…

Methodology · Statistics 2023-08-09 Rong Li , Qingzhao Zhang , Shuangge Ma

Artificial neural networks (ANNs) have been successfully applied to solve a variety of classification and function approximation problems. Although ANNs can generally predict better than decision trees for pattern classification problems,…

Neural and Evolutionary Computing · Computer Science 2010-09-28 S. M. Kamruzzaman , Md. Monirul Islam

State-of-the-art neural networks are getting deeper and wider. While their performance increases with the increasing number of layers and neurons, it is crucial to design an efficient deep architecture in order to reduce computational and…

Neural and Evolutionary Computing · Computer Science 2016-07-13 Hengyuan Hu , Rui Peng , Yu-Wing Tai , Chi-Keung Tang

Skull-stripping methods aim to remove the non-brain tissue from acquisition of brain scans in magnetic resonance (MR) imaging. Although several methods sharing this common purpose have been presented in literature, they all suffer from the…

Computer Vision and Pattern Recognition · Computer Science 2018-10-26 Gabriele Valvano , Nicola Martini , Andrea Leo , Gianmarco Santini , Daniele Della Latta , Emiliano Ricciardi , Dante Chiappino

This paper proposes a novel kernel-based optimization scheme to handle tasks in the analysis, e.g., signal spectral estimation and single-channel source separation of 1D non-stationary oscillatory data. The key insight of our optimization…

Machine Learning · Statistics 2022-12-12 Jieren Xu , Yitong Li , Haizhao Yang , David Dunson , Ingrid Daubechies

Regulatory networks describe the interactions between molecular or cellular regulators, like transcription factors and genes in gene regulatory networks, kinases and their receptors in signalling networks, or neurons in neural networks. A…

Molecular Networks · Quantitative Biology 2022-12-29 Niklas Bonacker , Johannes Berg

Deciphering complex gene-gene interactions remains challenging in transcriptomics as traditional methods often miss higher-order and nonlinear dependencies. This study introduces a quantum-inspired framework leveraging tensor networks (TNs)…

Molecular Networks · Quantitative Biology 2025-09-09 Olatz Sanz Larrarte , Borja Aizpurua , Reza Dastbasteh , Ruben M. Otxoa , Josu Etxezarreta Martinez

The application of Gaussian processes (GPs) to large data sets is limited due to heavy memory and computational requirements. A variety of methods has been proposed to enable scalability, one of which is to exploit structure in the kernel…

Machine Learning · Computer Science 2019-12-30 Jan Graßhoff , Alexandra Jankowski , Philipp Rostalski

In this work, the infinite GMRES algorithm, recently proposed by Correnty et al., is employed in contour integral-based nonlinear eigensolvers, avoiding the computation of costly factorizations at each quadrature node to solve the linear…

Numerical Analysis · Mathematics 2025-05-07 Yuqi Liu , Jose E. Roman , Meiyue Shao

The diagnosis of cyber-physical systems aims to detect faulty behaviour, its root cause and a mitigation or even prevention policy. Therefore, diagnosis relies on a representation of the system's functional and faulty behaviour combined…

Machine Learning · Computer Science 2021-10-13 Nicolas Olivain , Philipp Tiefenbacher , Jens Kohl

Deep learning has achieved remarkable success in graph-related tasks, yet this accomplishment heavily relies on large-scale high-quality annotated datasets. However, acquiring such datasets can be cost-prohibitive, leading to the practical…

Machine Learning · Computer Science 2024-03-11 Ling-Hao Chen , Yuanshuo Zhang , Taohua Huang , Liangcai Su , Zeyi Lin , Xi Xiao , Xiaobo Xia , Tongliang Liu

Living cells are the product of gene expression programs that involve the regulated transcription of thousands of genes. The elucidation of transcriptional regulatory networks in thus needed to understand the cell's working mechanism, and…

Quantitative Methods · Quantitative Biology 2011-02-21 Fantine Mordelet , Jean-Philippe Vert

The perspective of developing trustworthy AI for critical applications in science and engineering requires machine learning techniques that are capable of estimating their own uncertainty. In the context of regression, instead of estimating…

Machine Learning · Computer Science 2026-05-14 Quentin Duchemin , Guillaume Obozinski

Subgraph counting aims to count the occurrences of a subgraph template T in a given network G. The basic problem of computing structural properties such as counting triangles and other subgraphs has found applications in diverse domains.…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-03-12 Langshi Chen , Jiayu Li , Ariful Azad , Lei Jiang , Madhav Marathe , Anil Vullikanti , Andrey Nikolaev , Egor Smirnov , Ruslan Israfilov , Judy Qiu

Accurately inferring Gene Regulatory Networks (GRNs) is a critical and challenging task in biology. GRNs model the activatory and inhibitory interactions between genes and are inherently causal in nature. To accurately identify GRNs,…

Convolutional neural networks (CNN) have been extensively used for inverse problems. However, their prediction error for unseen test data is difficult to estimate a priori since the neural networks are trained using only selected data and…

Computer Vision and Pattern Recognition · Computer Science 2019-06-19 Eunju Cha , Jaeduck Jang , Junho Lee , Eunha Lee , Jong Chul Ye

Despite their success and widespread adoption, the opaque nature of deep neural networks (DNNs) continues to hinder trust, especially in critical applications. Current interpretability solutions often yield inconsistent or oversimplified…

Machine Learning · Computer Science 2024-10-10 Alec F. Diallo , Vaishak Belle , Paul Patras
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