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Generative neural networks are able to mimic intricate probability distributions such as those of handwritten text, natural images, etc. Since their inception several models were proposed. The most successful of these were based on…

Machine Learning · Computer Science 2024-09-18 Daniel N. Nissani

Being able to design genetic regulatory networks (GRNs) to achieve a desired cellular function is one of the main goals of synthetic biology. However, determining minimal GRNs that produce desired time-series behaviors is non-trivial. In…

Computational Engineering, Finance, and Science · Computer Science 2022-01-24 Javier Garcia-Bernardo , Margaret J. Eppstein

Probabilistic graphical models (PGMs) are widely used to discover latent structure in data, but their success hinges on selecting an appropriate model design. In practice, model specification is difficult and often requires iterative…

Machine Learning · Computer Science 2026-04-08 Kevin Zhang , Yixin Wang

The two most fundamental processes describing change in biology, development and evolu-tion, occur over drastically different timescales, difficult to reconcile within a unified framework. Development involves temporal sequences of cell…

Biological Physics · Physics 2020-09-08 Enrico Borriello , Sara I. Walker , Manfred D. Laubichler

Graph Neural Networks (GNN) have recently gained popularity in the forecasting domain due to their ability to model complex spatial and temporal patterns in tasks such as traffic forecasting and region-based demand forecasting. Most of…

Machine Learning · Computer Science 2023-12-08 Abishek Sriramulu , Nicolas Fourrier , Christoph Bergmeir

Gene Regulatory Networks (GRNs) are intricate biological systems that control gene expression and regulation in response to environmental and developmental cues. Advances in computational biology, coupled with high throughput sequencing…

Machine Learning · Computer Science 2025-04-18 Akshata Hegde , Tom Nguyen , Jianlin Cheng

We investigate the application of a multi-objective genetic algorithm to the problem of task allocation in a self-organizing, decentralized, threshold-based swarm. Each agent in our system is capable of performing four tasks with a response…

Multiagent Systems · Computer Science 2021-06-14 H. David Mathias , Annie S. Wu , Daniel Dang

This paper explores the use of a novel form of Hierarchical Graph Neurons (HGN) for in-operation behaviour selection in a swarm of robotic agents. This new HGN is called Robotic-HGN (R-HGN), as it matches robot environment observations to…

Robotics · Computer Science 2021-09-07 Phillip Smith , Aldeida Aleti , Vincent C. S. Lee , Robert Hunjet , Asad Khan

A powerful approach, and one of the most common ones in structural health monitoring (SHM), is to use data-driven models to make predictions and inferences about structures and their condition. Such methods almost exclusively rely on the…

Machine Learning · Computer Science 2022-03-04 G. Tsialiamanis , D. J. Wagg , N. Dervilis , K. Worden

Living organisms must respond to environmental changes. Generally, accurate and rapid responses are provided by simple, unidirectional networks that connect inputs with outputs. Besides accuracy and speed, biological responses should also…

Molecular Networks · Quantitative Biology 2021-09-01 Masayo Inoue , Kunihiko Kaneko

Composite materials with 3D architectures are desirable in a variety of applications for the capability of tailoring their properties to meet multiple functional requirements. By the arrangement of materials' internal components, structure…

Materials Science · Physics 2023-02-28 Zhengyang Zhang , Han Fang , Zhao Xu , Jiajie Lv , Yao Shen , Yanming Wang

We consider here the morphogenesis (pattern formation) problem for some genetic network models. First, we show that any given spatio-temporal pattern can be generated by a genetic network involving a sufficiently large number of genes.…

Dynamical Systems · Mathematics 2007-05-23 S. Genieys , S. Vakulenko

The reliability redundancy allocation problem (RRAP) is a well-known tool in system design, development, and management. The RRAP is always modeled as a nonlinear mixed-integer non-deterministic polynomial-time hardness (NP-hard) problem.…

Neural and Evolutionary Computing · Computer Science 2020-06-18 Wei-Chang Yeh

Genetic regulatory networks with adaptive responses are widely studied in biology. Usually, models consisting only of a few nodes have been considered. They present one input receptor for activation and one output node where the adaptive…

Molecular Networks · Quantitative Biology 2016-07-20 Pablo Kaluza , Masayo Inoue

Gene regulatory networks (GRNs) play a central role in cellular decision-making. Understanding their structure and how it impacts their dynamics constitutes thus a fundamental biological question. GRNs are frequently modeled as Boolean…

Molecular Networks · Quantitative Biology 2024-01-19 Claus Kadelka , Taras-Michael Butrie , Evan Hilton , Jack Kinseth , Addison Schmidt , Haris Serdarevic

Efficiently retrieving an enormous chemical library to design targeted molecules is crucial for accelerating drug discovery, organic chemistry, and optoelectronic materials. Despite the emergence of generative models to produce novel…

Computational Engineering, Finance, and Science · Computer Science 2024-09-13 Zijun Chen , Yu Wang , Liuzhenghao Lv , Hao Li , Zongying Lin , Li Yuan , Yonghong Tian

Score-based generative models (SGMs) have proven to be powerful tools for designing new proteins. Designing proteins that bind a pre-specified target is highly relevant to a range of medical and industrial applications. Despite the flurry…

Biomolecules · Quantitative Biology 2024-09-30 John D Boom , Matthew Greenig , Pietro Sormanni , Pietro Liò

The present study proposes a multi-objective framework for structure selection of nonlinear systems which are represented by polynomial NARX models. This framework integrates the key components of Multi-Criteria Decision Making (MCDM) which…

Systems and Control · Electrical Eng. & Systems 2019-08-20 Faizal Hafiz , Akshya Swain , Eduardo MAM Mendes

Effective operation and seamless cooperation of robotic systems are a fundamental component of next-generation technologies and applications. In contexts such as disaster response, swarm operations require coordinated behavior and mobility…

Multiagent Systems · Computer Science 2024-04-03 Raffaele Galliera , Thies Möhlenhof , Alessandro Amato , Daniel Duran , Kristen Brent Venable , Niranjan Suri

The evolutionary origins of structural features in reconstructed gene-regulatory networks (GRNs) remain poorly understood, especially given the random aspects of gene expression. Here, we extend a classical model of GRN evolution to allow a…

Populations and Evolution · Quantitative Biology 2026-04-30 Leonardo Ivan Estrella Dzib , James Holehouse