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Background: We describe an informatics framework for researchers and clinical investigators to efficiently perform parameter sensitivity analysis and auto-tuning for algorithms that segment and classify image features in a large dataset of…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-12-13 George Teodoro , Tahsin Kurc , Luis F. R. Taveira , Alba C. M. A. Melo , Jun Kong , Joel Saltz

With the increasingly availability of digital microscopy imagery equipments there is a demand for efficient execution of whole slide tissue image applications. Through the process of sensitivity analysis it is possible to improve the output…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-11-29 Willian de Oliveira Barreiros Junior , George Teodoro

Motivated by the pressing challenges in the digital twin development for biomanufacturing systems, we introduce an adjoint sensitivity analysis (SA) approach to expedite the learning of mechanistic model parameters. In this paper, we…

Molecular Networks · Quantitative Biology 2024-07-02 Keilung Choy , Wei Xie

Social Spider Algorithm (SSA) is a recently proposed general-purpose real-parameter metaheuristic designed to solve global numerical optimization problems. This work systematically benchmarks SSA on a suite of 11 functions with different…

Neural and Evolutionary Computing · Computer Science 2015-07-10 James J. Q. Yu , Victor O. K. Li

The sensitivity of parameters in computational science problems is difficult to assess, especially for algorithms with multiple input parameters and diverse outputs. This work seeks to explore sensitivity analysis in the visualization…

Global sensitivity analysis (GSA) is frequently used to analyze the influence of uncertain parameters in mathematical models and simulations. In principle, tools from GSA may be extended to analyze the influence of parameters in statistical…

Computation · Statistics 2018-06-29 Joseph Hart , Julie Bessac , Emil Constantinescu

Recently popularized randomized methods for principal component analysis (PCA) efficiently and reliably produce nearly optimal accuracy --- even on parallel processors --- unlike the classical (deterministic) alternatives. We adapt one of…

Computation · Statistics 2011-12-23 Nathan Halko , Per-Gunnar Martinsson , Yoel Shkolnisky , Mark Tygert

Reaction-diffusion models are widely used to study spatially-extended chemical reaction systems. In order to understand how the dynamics of a reaction-diffusion model are affected by changes in its input parameters, efficient methods for…

Quantitative Methods · Quantitative Biology 2017-03-08 Christopher Lester , Christian A. Yates , Ruth E. Baker

This work presents the second-order forward and adjoint sensitivity analysis procedures (SO-FSAP and SO-ASAP) for computing exactly and efficiently the second-order functional derivatives of physical (engineering, biological, etc.) system…

Mathematical Physics · Physics 2015-05-20 Dan G. Cacuci

The edge artificial intelligence (AI) applications in next-generation mobile networks demand efficient AI-model downloading techniques to support real-time, on-device inference. However, transmitting high-dimensional AI models over wireless…

Networking and Internet Architecture · Computer Science 2026-02-17 You Zhou , Qunsong Zeng , Kaibin Huang

Programs with high levels of complexity often face challenges in adjusting execution parameters, particularly when these parameters vary based on the execution context. These dynamic parameters significantly impact the program's…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-06-18 Joao B. Fernandes , Felipe H. S. da Silva , Samuel Xavier-de-Souza , Italo A. S. Assis

A main barrier for the deployment of AI radiomic systems in clinical routine is their drop in performance under heterogeneous multicentre acquisition protocols. This work presents a performance-oriented framework for quantifying scan…

Artificial Intelligence · Computer Science 2026-05-15 D. Gil , I. Sanchez , C. Sanchez

Self-supervised adaptation (SSA) improves foundation model transfer to medical domains but is computationally prohibitive. Although parameter efficient fine-tuning methods such as LoRA have been explored for supervised adaptation, their…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Moein Sorkhei , Emir Konuk , Jingyu Guo , Chanjuan Meng , Christos Matsoukas , Kevin Smith

In this paper we extend the parametric sensitivity analysis (SA) methodology proposed in Ref. [Y. Pantazis and M. A. Katsoulakis, J. Chem. Phys. 138, 054115 (2013)] to continuous time and continuous space Markov processes represented by…

Information Theory · Computer Science 2014-12-22 Anastasios Tsourtis , Yannis Pantazis , Markos A. Katsoulakis , Vagelis Harmandaris

Segment Anything Model (SAM) has received remarkable attention as it offers a powerful and versatile solution for object segmentation in images. However, fine-tuning SAM for downstream segmentation tasks under different scenarios remains a…

Computer Vision and Pattern Recognition · Computer Science 2023-12-19 Zelin Peng , Zhengqin Xu , Zhilin Zeng , Xiaokang Yang , Wei Shen

We provide a novel method for sensitivity analysis of parametric robust Markov chains. These models incorporate parameters and sets of probability distributions to alleviate the often unrealistic assumption that precise probabilities are…

Machine Learning · Computer Science 2023-05-03 Thom Badings , Sebastian Junges , Ahmadreza Marandi , Ufuk Topcu , Nils Jansen

We present a novel approach for adaptive, differentiable parameterization of large-scale random fields. If the approach is coupled with any gradient-based optimization algorithm, it can be applied to a variety of optimization problems,…

Machine Learning · Computer Science 2020-06-09 Maksim Elizarev , Andrei Mukhin , Aleksey Khlyupin

In this work, we introduce a Self-Aware Polymorphic Architecture (SAPA) design approach to support emerging context-aware applications and mitigate the programming challenges caused by the ever-increasing complexity and heterogeneity of…

Hardware Architecture · Computer Science 2018-02-15 Michel A. Kinsy , Mihailo Isakov , Alan Ehret , Donato Kava

The complexity and size of state-of-the-art cell models have significantly increased in part due to the requirement that these models possess complex cellular functions which are thought--but not necessarily proven--to be important. Modern…

Neurons and Cognition · Quantitative Biology 2018-11-22 J. L. Hart , P. A. Gremaud , T. David

Parameter sensitivity analysis is a powerful tool in the building and analysis of biochemical network models. For stochastic simulations, parameter sensitivity analysis can be computationally expensive, requiring multiple simulations for…

Computational Physics · Physics 2015-06-04 Patrick B. Warren , Rosalind J. Allen
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