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In precision medicine, Dynamic Treatment Regimes (DTRs) are treatment protocols that adapt over time in response to a patient's observed characteristics. A DTR is a set of decision functions that takes an individual patient's information as…

Methodology · Statistics 2022-03-17 Cong Jiang , Michael Wallace , Mary Thompson

Digital twins are virtual replicas of physical entities and are poised to transform personalized medicine through the real-time simulation and prediction of human physiology. Translating this paradigm from engineering to biomedicine…

Cognitive decline is highly heterogeneous across individuals, which complicates prognosis, trial design, and treatment planning. We present the Personalized Cognitive Decline Assessment Digital Twin (PCD-DT), a multimodal and…

Artificial Intelligence · Computer Science 2026-05-01 Bulent Soykan , Gulsah Hancerliogullari Koksalmis , Hsin-Hsiung Huang , Laura J. Brattain

While recent advances in AI-based automated decision-making have shown many benefits for businesses and society, they also come at a cost. It has for long been known that a high level of automation of decisions can lead to various…

Human-Computer Interaction · Computer Science 2021-09-29 Max Schemmer , Niklas Kühl , Gerhard Satzger

Generative AI systems are increasingly used by patients seeking everyday health guidance, yet their appropriateness in chronic care contexts remains unclear. Focusing on Type 2 Diabetes Mellitus (T2DM), this paper presents a mixed-methods…

Human-Computer Interaction · Computer Science 2026-01-06 Yibo Meng , Ruiqi Chen , Bingyi Liu , Yan Guan , Xiaolan Ding

Purpose: Digital twins are virtual interactive models of the real world, exhibiting identical behavior and properties. In surgical applications, computational analysis from digital twins can be used, for example, to enhance situational…

Driven by the dual principles of smart education and artificial intelligence technology, the online education model has rapidly emerged as an important component of the education industry. Cognitive diagnostic technology can utilize…

Artificial Intelligence · Computer Science 2025-10-28 Zhifeng Wang , Meixin Su , Yang Yang , Chunyan Zeng , Lizhi Ye

Remote medical response systems are increasingly being deployed to support emergency care in disaster-affected and infrastructure-limited environments. Enabled by GeoVision capabilities, this paper presents a Digital Twin architecture for…

Robotics · Computer Science 2026-04-16 Parham Kebria , Soheil Sabri , Laura J Brattain

This work develops a methodology for creating a data-driven digital twin from a library of physics-based models representing various asset states. The digital twin is updated using interpretable machine learning. Specifically, we use…

Computational Engineering, Finance, and Science · Computer Science 2020-04-30 Michael G. Kapteyn , Karen E. Willcox

A digital twin can be defined as an adaptive model of a complex physical system. Recent advances in computational pipelines, multiphysics solvers, artificial intelligence, big data cybernetics, data processing and management tools bring the…

Signal Processing · Electrical Eng. & Systems 2019-10-07 Adil Rasheed , Omer San , Trond Kvamsdal

Musculoskeletal disorders (MSDs) are a leading cause of disability worldwide, requiring advanced diagnostic and therapeutic tools for personalised assessment and treatment. Effective management of MSDs involves the interaction of…

Image and Video Processing · Electrical Eng. & Systems 2025-07-28 Martina Paccini , Simone Cammarasana , Giuseppe Patanè

Artificial intelligence (AI) systems accelerate medical workflows and improve diagnostic accuracy in healthcare, serving as second-opinion systems. However, the unpredictability of AI errors poses a significant challenge, particularly in…

This paper presents a novel methodological framework, called the Actor-Simulator, that incorporates the calibration of digital twins into model-based reinforcement learning for more effective control of stochastic systems with complex…

Machine Learning · Computer Science 2025-01-07 Hua Zheng , Wei Xie , Ilya O. Ryzhov , Keilung Choy

The integration of Deep Learning (DL) in System Dynamics (SD) modeling for transportation logistics offers significant advantages in scalability and predictive accuracy. However, these gains are often offset by the loss of explainability…

Artificial Intelligence · Computer Science 2025-09-11 Riccardo D'Elia , Alberto Termine , Francesco Flammini

Clinical decision-making is inherently complex, often influenced by cognitive biases, incomplete information, and case ambiguity. Large Language Models (LLMs) have shown promise as tools for supporting clinical decision-making, yet their…

Machine Learning · Computer Science 2025-07-10 Burcu Sayin , Ipek Baris Schlicht , Ngoc Vo Hong , Sara Allievi , Jacopo Staiano , Pasquale Minervini , Andrea Passerini

In this paper, we study a digital twin (DT)-empowered integrated sensing, communication, and computation network. Specifically, the users perform radar sensing and computation offloading on the same spectrum, while unmanned aerial vehicles…

Signal Processing · Electrical Eng. & Systems 2023-10-27 Bin Li , Wenshuai Liu , Wancheng Xie , Ning Zhang , Yan Zhang

Computer-aided diagnosis for medical imaging is a well-studied field that aims to provide real-time decision support systems for physicians. These systems attempt to detect and diagnose a plethora of medical conditions across a variety of…

Artificial Intelligence · Computer Science 2022-05-25 Glen Smith , Qiao Zhang , Christopher MacLellan

Clinical decision support using deep neural networks has become a topic of steadily growing interest. While recent work has repeatedly demonstrated that deep learning offers major advantages for medical image classification over traditional…

Image and Video Processing · Electrical Eng. & Systems 2022-06-10 Alexander Katzmann , Oliver Taubmann , Stephen Ahmad , Alexander Mühlberg , Michael Sühling , Horst-Michael Groß

Clinical decision-making is a feedback system where risk estimates influence treatment, which in turn changes disease trajectories, and both shape clinicians' measurement practices. Static prediction often fails clinically: models trained…

Artificial Intelligence · Computer Science 2026-05-19 Pujun Feng , Xiaoyu Guo , Seyed Ehsan Saffari , Min Hun Lee , Siew-Kei Lam , Erik Cambria , Xibin Sun , Yangtao Zhou , Tong Yang , Xiaoyu Zhang , Tao Tan , Yue Sun , Bin Cui

Optical communication is developing rapidly in the directions of hardware resource diversification, transmission system flexibility, and network function virtualization. Its proliferation poses a significant challenge to traditional optical…

Networking and Internet Architecture · Computer Science 2020-11-11 Danshi Wang , Zhiguo Zhang , Min Zhang , Meixia Fu , Jin Li , Shanyong Cai , Chunyu Zhang , Xue Chen