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For prostate cancer patients, the Gleason score is one of the most important prognostic factors, potentially determining treatment independent of the stage. However, Gleason scoring is based on subjective microscopic examination of tumor…

Disease prediction is a well-known classification problem in medical applications. GCNs provide a powerful tool for analyzing the patients' features relative to each other. This can be achieved by modeling the problem as a graph node…

Machine Learning · Computer Science 2021-11-09 Mahsa Ghorbani , Anees Kazi , Mahdieh Soleymani Baghshah , Hamid R. Rabiee , Nassir Navab

With the increase in the use of deep learning for computer-aided diagnosis in medical images, the criticism of the black-box nature of the deep learning models is also on the rise. The medical community needs interpretable models for both…

Image and Video Processing · Electrical Eng. & Systems 2020-12-21 Mookund Sureka , Abhijeet Patil , Deepak Anand , Amit Sethi

PURPOSE: Deep learning methods for classifying prostate cancer (PCa) in ultrasound images typically employ convolutional networks (CNNs) to detect cancer in small regions of interest (ROI) along a needle trace region. However, this approach…

Cervical cancer is the second most prevalent cancer affecting women today. As the early detection of cervical carcinoma relies heavily upon screening and pre-clinical testing, digital cervicography has great potential as a primary or…

Computer Vision and Pattern Recognition · Computer Science 2020-04-02 Yanglan Ou , Yuan Xue , Ye Yuan , Tao Xu , Vincent Pisztora , Jia Li , Xiaolei Huang

The recent development of high-throughput sequencing creates a large collection of multi-omics data, which enables researchers to better investigate cancer molecular profiles and cancer taxonomy based on molecular subtypes. Integrating…

Genomics · Quantitative Biology 2024-01-25 Bingjun Li , Sheida Nabavi

Graph Convolutional Networks (GCNs) have proven to be successful tools for semi-supervised learning on graph-based datasets. For sparse graphs, linear and polynomial filter functions have yielded impressive results. For large non-sparse…

Machine Learning · Computer Science 2019-05-27 Dominik Alfke , Martin Stoll

Spatial arrangement of cells of various types, such as tumor infiltrating lymphocytes and the advancing edge of a tumor, are important features for detecting and characterizing cancers. However, convolutional neural networks (CNNs) do not…

Image and Video Processing · Electrical Eng. & Systems 2019-08-15 Shrey Gadiya , Deepak Anand , Amit Sethi

The emergence of multi-parametric magnetic resonance imaging (mpMRI) has had a profound impact on the diagnosis of prostate cancers (PCa), which is the most prevalent malignancy in males in the western world, enabling a better selection of…

Prostate cancer (PCa) was the most frequently diagnosed cancer among American men in 2023. The histological grading of biopsies is essential for diagnosis, and various deep learning-based solutions have been developed to assist with this…

Image and Video Processing · Electrical Eng. & Systems 2024-09-16 Ekaterina Redekop , Mara Pleasure , Zichen Wang , Anthony Sisk , Yang Zong , Kimberly Flores , William Speier , Corey W. Arnold

Recently, Graph Convolutional Networks (GCNs) have proven to be a powerful mean for Computer Aided Diagnosis (CADx). This approach requires building a population graph to aggregate structural information, where the graph adjacency matrix…

Artificial Intelligence · Computer Science 2021-06-17 Hao Chen , Fuzhen Zhuang , Li Xiao , Ling Ma , Haiyan Liu , Ruifang Zhang , Huiqin Jiang , Qing He

Histopathological assessments, including surgical resection and core needle biopsy, are the standard procedures in the diagnosis of the prostate cancer. Current interpretation of the histopathology images includes the determination of the…

Computer Vision and Pattern Recognition · Computer Science 2017-05-12 Naiyun Zhou , Andrey Fedorov , Fiona Fennessy , Ron Kikinis , Yi Gao

Prostate cancer is one of the most common causes of cancer deaths in men. There is a growing demand for noninvasively and accurately diagnostic methods that facilitate the current standard prostate cancer risk assessment in clinical…

Image and Video Processing · Electrical Eng. & Systems 2021-12-30 Ping-Chang Lin , Teodora Szasz , Hakizumwami B. Runesha

Enhancing the robustness of deep learning models against adversarial attacks is crucial, especially in critical domains like healthcare where significant financial interests heighten the risk of such attacks. Whole slide images (WSIs) are…

Computer Vision and Pattern Recognition · Computer Science 2024-03-22 Saba Heidari Gheshlaghi , Milan Aryal , Nasim Yahyasoltani , Masoud Ganji

Generative Adversarial Networks (GANs) have shown considerable promise for mitigating the challenge of data scarcity when building machine learning-driven analysis algorithms. Specifically, a number of studies have shown that GAN-based…

Computer Vision and Pattern Recognition · Computer Science 2018-11-28 Xiaodan Hu , Audrey G. Chung , Paul Fieguth , Farzad Khalvati , Masoom A. Haider , Alexander Wong

Colorectal cancer (CRC) grading is typically carried out by assessing the degree of gland formation within histology images. To do this, it is important to consider the overall tissue micro-environment by assessing the cell-level…

Image and Video Processing · Electrical Eng. & Systems 2019-09-04 Yanning Zhou , Simon Graham , Navid Alemi Koohbanani , Muhammad Shaban , Pheng-Ann Heng , Nasir Rajpoot

Early detection of lung cancer is critical for improvement of patient survival. To address the clinical need for efficacious treatments, genetically engineered mouse models (GEMM) have become integral in identifying and evaluating the…

The exploration of cellular heterogeneity within the tumor microenvironment (TME) via single-cell RNA sequencing (scRNA-seq) is essential for understanding cancer progression and response to therapy. Current scRNA-seq approaches, however,…

Genomics · Quantitative Biology 2025-02-06 Yu-An Huang , Yue-Chao Li , Hai-Ru You , Jie Pan , Xiyue Cao , Xinyuan Li , Zhi-An Huang , Zhu-Hong You

Graph classification plays a pivotal role in various domains, including pathology, where images can be represented as graphs. In this domain, images can be represented as graphs, where nodes might represent individual nuclei, and edges…

Machine Learning · Computer Science 2025-01-29 Aditya Prakash

Graph-based learning approaches, due to their ability to encode tissue/organ structure information, are increasingly favored for grading colorectal cancer histology images. Recent graph-based techniques involve dividing whole slide images…

Image and Video Processing · Electrical Eng. & Systems 2024-05-14 Sudipta Paul , Bulent Yener , Amanda W. Lund