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Despite considerable progress in genome- and proteome-based high-throughput screening methods and in rational drug design, the increase in approved drugs in the past decade did not match the increase of drug development costs. Network…

Molecular Networks · Quantitative Biology 2013-05-14 Peter Csermely , Tamas Korcsmaros , Huba J. M. Kiss , Gabor London , Ruth Nussinov

Over the past few decades, statistical methods for causal inference have made impressive strides, enabling progress across a range of scientific fields. However, much of this methodological development has been confined to individual…

Methodology · Statistics 2025-09-30 Wenqi Shi , José R. Zubizarreta

Handling outliers is a fundamental challenge in multivariate data analysis because outliers may distort the structures of correlation or conditional independence. Although robust Bayesian inference has been extensively studied in univariate…

Methodology · Statistics 2025-10-27 Yasuyuki Hamura , Kaoru Irie , Shonosuke Sugasawa

Decomposing an exposure effect on an outcome into separate natural indirect effects through multiple mediators requires strict assumptions, such as correctly postulating the causal structure of the mediators, and no unmeasured confounding…

Methodology · Statistics 2021-02-04 Wen Wei Loh , Beatrijs Moerkerke , Tom Loeys , Stijn Vansteelandt

This study explores the impact of class outliers on the effectiveness of example-based explainability methods for black-box machine learning models. We reformulate existing explainability evaluation metrics, such as correctness and…

Machine Learning · Computer Science 2024-08-02 Ikhtiyor Nematov , Dimitris Sacharidis , Tomer Sagi , Katja Hose

Unsupervised outlier detection constitutes a crucial phase within data analysis and remains a dynamic realm of research. A good outlier detection algorithm should be computationally efficient, robust to tuning parameter selection, and…

Machine Learning · Statistics 2024-09-23 Sheikh Arafat , Na Sun , Maria L. Weese , Waldyn G. Martinez

Decisions based upon pairwise comparisons of multiple treatments are naturally performed in terms of the mean survival of the selected study arms or functions thereof. However, synthesis of treatment comparisons is usually performed on…

Applications · Statistics 2025-12-11 Anastasios Apsemidis , Dimitris Mavridis , Nikolaos Demiris

In the last few years, many works have tried to explain the predictions of deep learning models. Few methods, however, have been proposed to verify the accuracy or faithfulness of these explanations. Recently, influence functions, which is…

Machine Learning · Computer Science 2023-04-10 Jacob R. Epifano , Ravi P. Ramachandran , Aaron J. Masino , Ghulam Rasool

This paper introduces a universal approach to seamlessly combine out-of-distribution (OOD) detection scores. These scores encompass a wide range of techniques that leverage the self-confidence of deep learning models and the anomalous…

Machine Learning · Statistics 2024-06-25 Eduardo Dadalto , Florence Alberge , Pierre Duhamel , Pablo Piantanida

Online network crawling tasks require a lot of efforts for the researchers to collect the data. One of them is identification of important nodes, which has many applications starting from viral marketing to the prevention of disease spread.…

Social and Information Networks · Computer Science 2024-03-22 Mikhail Drobyshevskiy , Denis Aivazov , Denis Turdakov , Alexander Yatskov , Maksim Varlamov , Danil Shayhelislamov

Influence estimation methods promise to explain and debug machine learning by estimating the impact of individual samples on the final model. Yet, existing methods collapse under training randomness: the same example may appear critical in…

Machine Learning · Computer Science 2026-04-06 Subhodip Panda , Dhruv Tarsadiya , Shashwat Sourav , Prathosh A. P , Sai Praneeth Karimireddy

Modern multi-centre randomized controlled trials (MCRCTs) collect massive amounts of tabular data, and are monitored intensively for irregularities by humans. We began by empirically evaluating 6 modern machine learning-based outlier…

Machine Learning · Computer Science 2023-11-10 Walter Nelson , Jonathan Ranisau , Jeremy Petch

This paper considers inference in a linear instrumental variable regression model with many potentially weak instruments, in the presence of heterogeneous treatment effects. I first show that existing test procedures, including those that…

Econometrics · Economics 2025-04-24 Luther Yap

Random-effects meta-analyses have been widely applied in evidence synthesis for various types of medical studies. However, standard inference methods (e.g. restricted maximum likelihood estimation) usually underestimate statistical errors…

Methodology · Statistics 2019-05-13 Shonosuke Sugasawa , Hisashi Noma

How should researchers conduct causal inference when the outcome of interest is latent and measured imperfectly by multiple indicators? We develop a general nonparametric framework for identifying and estimating average treatment effects on…

Methodology · Statistics 2026-04-22 Jiawei Fu , Donald P. Green

A reliable inference of networks from data is of key interest in the Neurosciences. Several methods have been suggested in the literature to reliably determine links in a network. To decide about the presence of links, these techniques rely…

Physics and Society · Physics 2018-06-29 Gloria Cecchini , Marco Thiel , Bjoern Schelter , Linda Sommerlade

The impact of AI models on marginalized communities has traditionally been measured by identifying performance differences between specified demographic subgroups. Though this approach aims to center vulnerable groups, it risks obscuring…

Computation and Language · Computer Science 2023-12-05 Vyoma Raman , Eve Fleisig , Dan Klein

Causal discovery is to learn cause-effect relationships among variables given observational data and is important for many applications. Existing causal discovery methods assume data sufficiency, which may not be the case in many real world…

Machine Learning · Computer Science 2022-06-20 Zijun Cui , Naiyu Yin , Yuru Wang , Qiang Ji

It is widely recognized that deep neural networks are sensitive to bias in the data. This means that during training these models are likely to learn spurious correlations between data and labels, resulting in limited generalization…

Machine Learning · Computer Science 2024-12-06 Vito Paolo Pastore , Massimiliano Ciranni , Davide Marinelli , Francesca Odone , Vittorio Murino

As machine learning is increasingly deployed in the real world, it is paramount that we develop the tools necessary to analyze the decision-making of the models we train and deploy to end-users. Recently, researchers have shown that…

Machine Learning · Computer Science 2022-05-05 Andrew Silva , Rohit Chopra , Matthew Gombolay