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In a network meta-analysis, some of the collected studies may deviate markedly from the others, for example having very unusual effect sizes. These deviating studies can be regarded as outlying with respect to the rest of the network and…

Methodology · Statistics 2023-01-11 Silvia Metelli , Dimitris Mavridis , Perrine Créquit , Anna Chaimani

Network meta-analysis is an evidence synthesis method for comparing the effectiveness of multiple available treatments. To justify evidence synthesis, consistency is an important assumption; however, existing methods founded on statistical…

Methodology · Statistics 2025-04-29 Kotaro Sasaki , Hisashi Noma

Meta-analyses of diagnostic test accuracy (DTA) studies have been gaining prominence in research in clinical epidemiology and health technology development. In these DTA meta-analyses, some studies may have markedly different…

Methodology · Statistics 2021-07-14 Yuki Matsushima , Hisashi Noma , Tomohide Yamada , Toshi A. Furukawa

Outlying observations are frequently encountered across a wide spectrum of scientific domains, posing notable challenges to the generalizability of statistical models and the reproducibility of downstream analysis. They are identified…

Methodology · Statistics 2026-03-17 Dongliang Zhang , Masoud Asgharian , Martin A. Lindquist

A core data-centric learning challenge is the identification of training samples that are detrimental to model performance. Influence functions serve as a prominent tool for this task and offer a robust framework for assessing training data…

Machine Learning · Computer Science 2025-11-04 Anshuman Chhabra , Bo Li , Jian Chen , Prasant Mohapatra , Hongfu Liu

It has become routine in neuroscience studies to measure brain networks for different individuals using neuroimaging. These networks are typically expressed as adjacency matrices, with each cell containing a summary of connectivity between…

Methodology · Statistics 2022-06-30 Pritam Dey , Zhengwu Zhang , David B. Dunson

In diagnostic test accuracy meta-analysis (DTA-MA), standard inference methods using bivariate random-effects models for jointly synthesizing sensitivity and specificity can be sensitive to outlying studies and may yield misleading…

Methodology · Statistics 2026-05-01 Kotaro Sasaki , Hisashi Noma , Theodoros Evrenoglou

Random effects meta-analysis model is an important tool for integrating results from multiple independent studies. However, the standard model is based on the assumption of normal distributions for both random effects and within-study…

Methodology · Statistics 2024-06-07 Yue Wang , Jianhua Zhao , Fen Jiang , Lei Shi , Jianxin Pan

Outlier detection can serve as an extremely important tool for researchers from a wide range of fields. From the sectors of banking and marketing to the social sciences and healthcare sectors, outlier detection techniques are very useful…

Methodology · Statistics 2023-12-12 Efthymios Costa , Ioanna Papatsouma

Background: Pairwise and network meta-analyses using fixed effect and random effects models are commonly applied to synthesise evidence from randomised controlled trials. The models differ in their assumptions and the interpretation of the…

Methodology · Statistics 2017-08-04 Shijie Ren , Jeremy E. Oakley , John W. Stevens

Measuring heterogeneous influence across nodes in a network is critical in network analysis. This paper proposes an Inward and Outward Network Influence (IONI) model to assess nodal heterogeneity. Specifically, we allow for two types of…

Methodology · Statistics 2022-05-17 Yujia Wu , Wei Lan , Tao Zou , Chih-Ling Tsai

The presence of units with extreme values in the dependent and/or independent variables (i.e., vertical outliers, leveraged data) has the potential to severely bias regression coefficients and/or standard errors. This is common with short…

Econometrics · Economics 2023-12-12 Annalivia Polselli

Entities whose changes will significantly affect others in a networked system are called shakers. In recent years, some models have been proposed to detect such shaker from evolving entities. However, limited work has focused on shaker…

Computers and Society · Computer Science 2023-03-14 Chang Liao

Random-effects meta-analyses are very commonly used in medical statistics. Recent methodological developments include multivariate (multiple outcomes) and network (multiple treatments) meta-analysis. Here we provide a new model and…

Methodology · Statistics 2017-08-16 Dan Jackson , Sylwia Bujkiewicz , Martin Law , Richard D Riley , Ian White

Outliers arise in networks due to different reasons such as fraudulent behavior of malicious users or default in measurement instruments and can significantly impair network analyses. In addition, real-life networks are likely to be…

Machine Learning · Statistics 2020-12-02 Solenne Gaucher , Olga Klopp , Geneviève Robin

Estimating causal effects under interference, where the stable unit treatment value assumption is violated, is critical in fields such as regional and public economics. Much of the existing research on causal inference under interference…

Methodology · Statistics 2026-02-03 Akihiro Sato , Shonosuke Sugasawa

Random effects meta-analysis is widely used for synthesizing studies under the assumption that underlying effects come from a normal distribution. However, under certain conditions the use of alternative distributions might be more…

The impact of outliers and anomalies on model estimation and data processing is of paramount importance, as evidenced by the extensive body of research spanning various fields over several decades: thousands of research papers have been…

Artificial Intelligence · Computer Science 2023-12-13 Madalina Olteanu , Fabrice Rossi , Florian Yger

Multivariate meta-analysis is gaining prominence in evidence synthesis research because it enables simultaneous synthesis of multiple correlated outcome data, and random-effects models have generally been used for addressing between-studies…

Methodology · Statistics 2021-07-14 Hisashi Noma , Kengo Nagashima , Toshi A. Furukawa

Meta-analysis of genome-wide association studies is increasingly popular and many meta-analytic methods have been recently proposed. A majority of meta-analytic methods combine information from multiple studies by assuming that studies are…

Quantitative Methods · Quantitative Biology 2014-01-20 Buhm Han , Jae Hoon Sul , Eleazar Eskin , Paul I. W. de Bakker , Soumya Raychaudhuri
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