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The ability to determine if the brain is developing normally is a key component of pediatric neuroradiology and neurology. Brain magnetic resonance imaging (MRI) of infants demonstrates a specific pattern of development beyond simply…

Image and Video Processing · Electrical Eng. & Systems 2020-10-09 M. Shabanian , A. Siddiqui , H. Chen , J. P. DeVincenzo

Determining if the brain is developing normally is a key component of pediatric neuroradiology and neurology. Brain magnetic resonance imaging (MRI) of infants demonstrates a specific pattern of development beyond simply myelination. While…

Image and Video Processing · Electrical Eng. & Systems 2021-12-28 Mahdieh Shabanian , Markus Wenzel , John P. DeVincenzo

Understanding human fetal neurodevelopment is of great clinical importance as abnormal development is linked to adverse neuropsychiatric outcomes after birth. Recent advances in functional Magnetic Resonance Imaging (fMRI) have provided new…

Image and Video Processing · Electrical Eng. & Systems 2019-06-11 Xiangrui Li , Jasmine Hect , Moriah Thomason , Dongxiao Zhu

Important applications of advancements in machine learning, are in the area of healthcare, more so for neurological disorder detection. A crucial step towards understanding the neurological status, is to estimate the brain age using…

Image and Video Processing · Electrical Eng. & Systems 2024-07-10 Vamshi Krishna Kancharla , Neelam Sinha

Given the wide success of convolutional neural networks (CNNs) applied to natural images, researchers have begun to apply them to neuroimaging data. To date, however, exploration of novel CNN architectures tailored to neuroimaging data has…

Computer Vision and Pattern Recognition · Computer Science 2018-08-15 Pascal Sturmfels , Saige Rutherford , Mike Angstadt , Mark Peterson , Chandra Sripada , Jenna Wiens

Brain age estimation from Magnetic Resonance Images (MRI) derives the difference between a subject's biological brain age and their chronological age. This is a potential biomarker for neurodegeneration, e.g. as part of Alzheimer's disease.…

Computer Vision and Pattern Recognition · Computer Science 2020-10-02 Kyriaki-Margarita Bintsi , Vasileios Baltatzis , Arinbjörn Kolbeinsson , Alexander Hammers , Daniel Rueckert

Chronological age of healthy people is able to be predicted accurately using deep neural networks from neuroimaging data, and the predicted brain age could serve as a biomarker for detecting aging-related diseases. In this paper, a novel 3D…

Image and Video Processing · Electrical Eng. & Systems 2021-06-08 Jian Cheng , Ziyang Liu , Hao Guan , Zhenzhou Wu , Haogang Zhu , Jiyang Jiang , Wei Wen , Dacheng Tao , Tao Liu

Accurate estimation of biological brain age from three dimensional (3D) T$_1$-weighted magnetic resonance imaging (MRI) is a critical imaging biomarker for identifying accelerated aging associated with neurodegenerative diseases. Effective…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Mehreen Kanwal , Yunsik Son

Individuals age differently depending on a multitude of different factors such as lifestyle, medical history and genetics. Often, the global chronological age is not indicative of the true ageing process. An organ-based age estimation would…

Image and Video Processing · Electrical Eng. & Systems 2020-12-29 Karim Armanious , Sherif Abdulatif , Anish Rao Bhaktharaguttu , Thomas Küstner , Tobias Hepp , Sergios Gatidis , Bin Yang

Estimated brain age from magnetic resonance image (MRI) and its deviation from chronological age can provide early insights into potential neurodegenerative diseases, supporting early detection and implementation of prevention strategies.…

Using 3D CNNs on high resolution medical volumes is very computationally demanding, especially for large datasets like the UK Biobank which aims to scan 100,000 subjects. Here we demonstrate that using 2D CNNs on a few 2D projections…

Image and Video Processing · Electrical Eng. & Systems 2023-03-14 Johan Jönemo , Muhammad Usman Akbar , Robin Kämpe , J Paul Hamilton , Anders Eklund

Myelination plays an important role in the neurological development of infant brain and MRI can visualize the myelination extension as T1 high and T2 low signal intensity at white matter. We tried to construct a convolutional neural network…

Early diagnosis, playing an important role in preventing progress and treating the Alzheimer's disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related…

Machine Learning · Computer Science 2016-07-05 Ehsan Hosseini-Asl , Georgy Gimel'farb , Ayman El-Baz

Prediction of the cognitive evolution of a person susceptible to develop a neurodegenerative disorder is crucial to provide an appropriate treatment as soon as possible. In this paper we propose a 3D siamese network designed to extract…

Image and Video Processing · Electrical Eng. & Systems 2019-09-04 Cecilia Ostertag , Marie Beurton-Aimar , Thierry Urruty

Brain age gap estimation (BrainAGE) is a promising imaging-derived biomarker of neurobiological aging and disease risk, yet current approaches rely predominantly on T1-weighted structural MRI (T1w), overlooking functional vascular changes…

Image and Video Processing · Electrical Eng. & Systems 2025-12-10 Jordan Jomsky , Kay C. Igwe , Zongyu Li , Yiren Zhang , Max Lashley , Tal Nuriel , Andrew Laine , Jia Guo

Human brain development is a complex and dynamic process that begins during the first weeks of pregnancy and lasts until early adulthood. This chapter focuses on the developmental window from prenatal period to infancy, probably the most…

Neurons and Cognition · Quantitative Biology 2025-05-01 Arnaud Cachia , Jean-François Mangin , Jessica Dubois

Machine learning analysis of neuroimaging data can accurately predict chronological age in healthy people and deviations from healthy brain ageing have been associated with cognitive impairment and disease. Here we sought to further…

Brain age prediction based on children's brain MRI is an important biomarker for brain health and brain development analysis. In this paper, we consider the 3D brain MRI volume as a sequence of 2D images and propose a new framework using…

Computer Vision and Pattern Recognition · Computer Science 2020-02-24 Sheng He , Randy L. Gollub , Shawn N. Murphy , Juan David Perez , Sanjay Prabhu , Rudolph Pienaar , Richard L. Robertson , P. Ellen Grant , Yangming Ou

Precise 3D segmentation of infant brain tissues is an essential step towards comprehensive volumetric studies and quantitative analysis of early brain developement. However, computing such segmentations is very challenging, especially for…

Computer Vision and Pattern Recognition · Computer Science 2017-12-20 Jose Dolz , Christian Desrosiers , Li Wang , Jing Yuan , Dinggang Shen , Ismail Ben Ayed
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