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Spatial transcriptomics studies are becoming increasingly large and commonplace, necessitating simultaneous analysis of a large number of spatially resolved variables. Correspondingly, a diverse range of methodologies have been proposed to…

Quantitative Methods · Quantitative Biology 2025-09-09 James Boyle , Gregory Hamm , Eleanor Williams , Robin JG Hartman , Magnus Soderburg , Ian Henry , Michael Casey

Persistent homology is a powerful tool for characterizing the topology of a data set at various geometric scales. When applied to the description of molecular structures, persistent homology can capture the multiscale geometric features and…

Quantitative Methods · Quantitative Biology 2018-07-31 Zixuan Cang , Guo-Wei Wei

Persistent homology is a central methodology in topological data analysis that has been successfully implemented in many fields and is becoming increasingly popular and relevant. The output of persistent homology is a persistence diagram --…

Statistics Theory · Mathematics 2024-04-24 Konstantin Häberle , Barbara Bravi , Anthea Monod

In recent years, cosmic shear has emerged as a powerful tool to study the statistical distribution of matter in our Universe. Apart from the standard two-point correlation functions, several alternative methods like peak count statistics…

Cosmology and Nongalactic Astrophysics · Physics 2021-04-21 Sven Heydenreich , Benjamin Brück , Joachim Harnois-Déraps

We propose a method for the unsupervised clustering of hyperspectral images based on spatially regularized spectral clustering with ultrametric path distances. The proposed method efficiently combines data density and geometry to…

Computer Vision and Pattern Recognition · Computer Science 2020-04-13 Shukun Zhang , James M. Murphy

Clustering high-dimensional spatiotemporal data using an unsupervised approach is a challenging problem for many data-driven applications. Existing state-of-the-art methods for unsupervised clustering use different similarity and distance…

Machine Learning · Computer Science 2023-09-15 Omar Faruque , Francis Ndikum Nji , Mostafa Cham , Rohan Mandar Salvi , Xue Zheng , Jianwu Wang

Persistent homology is a mathematical tool used for studying the shape of data by extracting its topological features. It has gained popularity in network science due to its applicability in various network mining problems, including…

Algebraic Topology · Mathematics 2023-06-21 Mehmet Emin Aktas , Thu Nguyen , Rakin Riza , Muhammad Ifte Islam , Esra Akbas

A central problem in data-driven scientific inquiry is how to interpret structure in noisy, high-dimensional data. Topological data analysis (TDA) provides a solution via persistent homology, which encodes features of interest as…

Algebraic Topology · Mathematics 2026-02-04 Christian Lentz , Gregory Henselman-Petrusek , Lori Ziegelmeier

Latent space matching, which consists of matching distributions of features in latent space, is a crucial component for tasks such as adversarial attacks and defenses, domain adaptation, and generative modelling. Metrics for probability…

Machine Learning · Computer Science 2025-03-05 Hiu-Tung Wong , Darrick Lee , Hong Yan

In unsupervised feature learning, sample specificity based methods ignore the inter-class information, which deteriorates the discriminative capability of representation models. Clustering based methods are error-prone to explore the…

Computer Vision and Pattern Recognition · Computer Science 2020-07-16 Yifei Zhang , Chang Liu , Yu Zhou , Wei Wang , Weiping Wang , Qixiang Ye

Computational topology has recently known an important development toward data analysis, giving birth to the field of topological data analysis. Topological persistence, or persistent homology, appears as a fundamental tool in this field.…

Statistics Theory · Mathematics 2013-05-28 Frédéric Chazal , Marc Glisse , Catherine Labruère , Bertrand Michel

Clustering can be defined as the process of assembling objects into a number of groups whose elements are similar to each other in some manner. As a technique that is used in many domains, such as face clustering, plant categorization,…

Machine Learning · Computer Science 2022-04-05 Mehmet F. Demirel , Enrico Au-Yeung

The task of clustering unlabeled time series and sequences entails a particular set of challenges, namely to adequately model temporal relations and variable sequence lengths. If these challenges are not properly handled, the resulting…

Machine Learning · Statistics 2019-02-19 Daniel J. Trosten , Andreas S. Strauman , Michael Kampffmeyer , Robert Jenssen

This paper considers the problem of subspace clustering under noise. Specifically, we study the behavior of Sparse Subspace Clustering (SSC) when either adversarial or random noise is added to the unlabelled input data points, which are…

Machine Learning · Statistics 2015-01-23 Yu-Xiang Wang , Huan Xu

Finding an optimal parameter of a black-box function is important for searching stable material structures and finding optimal neural network structures, and Bayesian optimization algorithms are widely used for the purpose. However, most of…

Machine Learning · Computer Science 2019-02-27 Tatsuya Shiraishi , Tam Le , Hisashi Kashima , Makoto Yamada

Topological methods have the potential of exploring data clouds without making assumptions on their the structure. Here we propose a hierarchical topological clustering algorithm that can be implemented with any distance choice. The…

Machine Learning · Computer Science 2026-02-10 Ana Carpio , Gema Duro

This paper introduces an unsupervised method to estimate the class separability of text datasets from a topological point of view. Using persistent homology, we demonstrate how tracking the evolution of embedding manifolds during training…

Machine Learning · Computer Science 2024-06-19 Kostis Gourgoulias , Najah Ghalyan , Maxime Labonne , Yash Satsangi , Sean Moran , Joseph Sabelja

In this paper we describe the mathematical foundations of a new approach to semi-supervised Machine Learning. Using techniques of Symbolic Computation and Computer Algebra, we apply the concept of persistent homology to obtain a new…

Machine Learning · Computer Science 2023-01-30 Adrián Inés , César Domínguez , Jónathan Heras , Gadea Mata , Julio Rubio

Cluster analysis methods seek to partition a data set into homogeneous subgroups. It is useful in a wide variety of applications, including document processing and modern genetics. Conventional clustering methods are unsupervised, meaning…

Methodology · Statistics 2014-07-11 Eric Bair

Classifying images often requires manual identification of qualitative features. Machine learning approaches including convolutional neural networks can achieve accuracy comparable to human classifiers, but require extensive data and…

Atomic Physics · Physics 2022-09-05 Daniel Leykam , Irving Rondon , Dimitris G Angelakis