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In the 21st century, biosensors have gathered much wider attention than ever before, irrespective of the technology that promises to bring them forward. With the recent COVID-19 outbreak, the concern and efforts to restore global health and…

Medical Physics · Physics 2023-02-14 Vinayak Pachkawade

Current efforts in the biomedical sciences and related interdisciplinary fields are focused on gaining a molecular understanding of health and disease, which is a problem of daunting complexity that spans many orders of magnitude in…

Quantitative Methods · Quantitative Biology 2014-01-24 Julián Candia , Jayanth R. Banavar , Wolfgang Losert

Accurate and comprehensive diatomic molecular spectroscopic data have long been vital in a wide variety of applications for measuring and monitoring astrophysical, industrial and other gaseous environments. These data are also used…

Chemical Physics · Physics 2021-03-19 Laura K. McKemmish

Microbial identification is a central issue in microbiology, in particular in the fields of infectious diseases diagnosis and industrial quality control. The concept of species is tightly linked to the concept of biological and clinical…

Machine Learning · Statistics 2015-06-25 Kévin Vervier , Pierre Mahé , Jean-Baptiste Veyrieras , Jean-Philippe Vert

Major biological discoveries have been made by interrogating living organisms with light. However, the limited penetration of unscattered photons within biological tissues severely limits the depth range covered by optical methods.…

Microscopy is the workhorse of the physical and life sciences, producing crisp images of everything from atoms to cells well beyond the capabilities of the human eye. However, the analysis of these images is frequently little better than…

Soft Condensed Matter · Physics 2017-10-18 Matthew Bierbaum , Brian D. Leahy , Alexander A. Alemi , Itai Cohen , James P. Sethna

The fast-growing field of soft matter research requires increasingly sophisticated tools for experimental studies. One of the oldest and most widely used tools to study soft matter systems is optical microscopy. Recent advances in optical…

Soft Condensed Matter · Physics 2011-08-17 Taewoo Lee , Bohdan Senyuk , Rahul P. Trivedi , Ivan I. Smalyukh

Multidimensional imaging techniques provide powerful ways to examine various kinds of scientific questions. The routinely produced datasets in the terabyte-range, however, can hardly be analyzed manually and require an extensive use of…

Computer Vision and Pattern Recognition · Computer Science 2016-08-31 Johannes Stegmaier

Miniaturized endoscopy has advanced accurate visual perception within the human body. Prevailing research remains limited to conventional cameras employing convex lenses, where the physical constraints with millimetre-scale thickness impose…

Computer Vision and Pattern Recognition · Computer Science 2025-08-06 Wuyang Li , Wentao Pan , Xiaoyuan Liu , Zhendong Luo , Chenxin Li , Hengyu Liu , Din Ping Tsai , Mu Ku Chen , Yixuan Yuan

Marine microalgae are widespread in the ocean and play a crucial role in the ecosystem. Automatic identification and location of marine microalgae in microscopy images would help establish marine ecological environment monitoring and water…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Shizheng Zhou , Juntao Jiang , Xiaohan Hong , Yan Hong , Pengcheng Fu

We construct an image formation theory that covers the majority of optical microscopy techniques that use diverse coherent or incoherent light-matter interactions. The theories of individual microscopy methods could not previously be…

Optics · Physics 2025-07-30 Naoki Fukutake , Shuichi Makita , Yoshiaki Yasuno

Metadata is one of the most important aspects for advancing data management practices within all research communities. Definitions and schemes of metadata are inter alia of particular significance in the domain of neutron and photon…

Data Analysis, Statistics and Probability · Physics 2025-01-29 Amir Tosson , Mohammad Reza , Christian Gutt

Modern research in the life sciences is unthinkable without computational methods for extracting, quantifying and visualizing information derived from biological microscopy imaging data. In the past decade, we observed a dramatic increase…

Security especially in the fields of IoT, industrial automation and critical infrastructure is paramount nowadays and a hot research topic. In order to ensure confidence in research results they need to be reproducible. In the past we…

Hardware Architecture · Computer Science 2024-07-10 Dmytro Petryk , Ievgen Kabin , Peter Langendörfer , Zoya Dyka

The conversion of phase variations in an optical wavefield into intensity information is of fundamental importance for optical imaging technology including microscopy of biological cells. While conventional approaches to phase-imaging…

Optics · Physics 2022-09-07 Lukas Wesemann , Jon Rickett , Timothy J. Davis , Ann Roberts

Segmentation, or the outlining of objects within images, is a critical step in the measurement and analysis of cells within microscopy images. While improvements continue to be made in tools that rely on classical methods for segmentation,…

Quantitative Methods · Quantitative Biology 2024-03-15 Nodar Gogoberidze , Beth A. Cimini

Recently developed technologies to generate single-cell genomic data have made a revolutionary impact in the field of biology. Multi-omics assays offer even greater opportunities to understand cellular states and biological processes.…

Genomics · Quantitative Biology 2022-01-19 Stefan Stanojevic , Yijun Li , Lana X. Garmire

The scarcity of high-quality data remains a primary bottleneck in adapting multimodal generative models for medical image editing. Existing medical image editing datasets often suffer from limited diversity, neglect of medical image…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Yongfan Lai , Wen Qian , Bo Liu , Hongyan Li , Hao Luo , Fan Wang , Bohan Zhuang , Shenda Hong

In the interdisciplinary field of microscopy research, managing and integrating large volumes of data stored across disparate platforms remains a major challenge. Data types such as bioimages, experimental records, and spectral information…

Computational Engineering, Finance, and Science · Computer Science 2025-08-29 Rodrigo Escobar Díaz Guerrero , Jamile Mohammad Jafari , Tobias Meyer-Zedler , Michael Schmitt , Juergen Popp , Thomas Bocklitz