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Background: The study of genome-scale metabolic models and their underlying networks is one of the most important fields in systems biology. The complexity of these models and their description makes the use of computational tools an…

Molecular Networks · Quantitative Biology 2012-12-03 D. Gamermann , A. Montagud , R. A. Jaime Infante , J. Triana , P. F. de Córdoba , J. F. Urchueguía

Von Neumann architecture based computers isolate/physically separate computation and storage units i.e. data is shuttled between computation unit (processor) and memory unit to realize logic/ arithmetic and storage functions. This…

Emerging Technologies · Computer Science 2020-02-17 Sandeep Kaur Kingra , Vivek Parmar , Che-Chia Chang , Boris Hudec , Tuo-Hung Hou , Manan Suri

Compute in-memory (CIM) is a promising technique that minimizes data transport, the primary performance bottleneck and energy cost of most data intensive applications. This has found wide-spread adoption in accelerating neural networks for…

Signal Processing · Electrical Eng. & Systems 2021-02-16 Brian Crafton , Samuel Spetalnick , Arijit Raychowdhury

Graph Neural Networks (GNNs) are emerging ML models to analyze graph-structure data. Graph Neural Network (GNN) execution involves both compute-intensive and memory-intensive kernels, the latter dominates the total time, being significantly…

Long short-term memory (LSTM) is one of the robust recurrent neural network architectures for learning sequential data. However, it requires considerable computational power to learn and implement both software and hardware aspects. This…

Machine Learning · Computer Science 2023-01-13 Nelly Elsayed , Zag ElSayed , Anthony S. Maida

Memory persistency models provide a foundation for persistent programming by specifying which (and when) writes to non-volatile memory (NVM) become persistent. Memory persistency models for the Intel-x86 and Arm architectures have been…

Programming Languages · Computer Science 2024-05-30 Vasileios Klimis , Alastair F. Donaldson , Viktor Vafeiadis , John Wickerson , Azalea Raad

Biologically inspired model (BIM) for image recognition is a robust computational architecture, which has attracted widespread attention. BIM can be described as a four-layer structure based on the mechanisms of the visual cortex. Although…

Computer Vision and Pattern Recognition · Computer Science 2017-10-30 Yan-Feng Lu , Li-Hao Jia , Hong Qaio , Yi Li

Processing-in-memory (PIM) is a promising choice for accelerating deep neural networks (DNNs) featuring high efficiency and low power. However, the rapid upscaling of neural network model sizes poses a crucial challenge for the limited…

Hardware Architecture · Computer Science 2024-11-21 Ruibao Wang , Bonan Yan

Machine learning continues to grow in popularity in academia, in industry, and is increasingly used in other fields. However, most of the common metrics used to evaluate even simple binary classification models have shortcomings that are…

Machine Learning · Computer Science 2024-12-25 David H. Brown , Davide Chicco

Machine-learned interatomic potentials (MLIPs) are revolutionizing computational materials science and chemistry by offering an efficient alternative to {\em ab initio} molecular dynamics (MD) simulations. However, fitting high-quality…

Computational Physics · Physics 2025-12-12 Ilgar Baghishov , Jan Janssen , Graeme Henkelman , Danny Perez

This document discusses the Information Theoretically Efficient Model (ITEM), a computerized system to generate an information theoretically efficient multinomial logistic regression from a general dataset. More specifically, this model is…

Machine Learning · Computer Science 2014-11-05 Tyler Ward

Large Language Models (LLMs) are typically trained in two phases: pre-training on large internet-scale datasets, and fine-tuning for downstream tasks. Given the higher computational demand of pre-training, it's intuitive to assume that…

Machine Learning · Computer Science 2024-10-15 James Liu , Guangxuan Xiao , Kai Li , Jason D. Lee , Song Han , Tri Dao , Tianle Cai

In-memory computing is a promising approach to addressing the processor-memory data transfer bottleneck in computing systems. We propose Spin-Transfer Torque Compute-in-Memory (STT-CiM), a design for in-memory computing with Spin-Transfer…

Emerging Technologies · Computer Science 2017-11-22 Shubham Jain , Ashish Ranjan , Kaushik Roy , Anand Raghunathan

Over the past 15 years, hundreds of bias mitigation methods have been proposed in the pursuit of fairness in machine learning (ML). However, algorithmic biases are domain-, task-, and model-specific, leading to a `portability trap': bias…

Machine Learning · Computer Science 2025-05-29 MaryBeth Defrance , Guillaume Bied , Maarten Buyl , Jefrey Lijffijt , Tijl De Bie

High-end ARM processors are emerging in data centers and HPC systems, posing as a strong contender to x86 machines. Memory-centric profiling is an important approach for dissecting an application's bottlenecks on memory access and guiding…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-10-03 Samuel Miksits , Ruimin Shi , Maya Gokhale , Jacob Wahlgren , Gabin Schieffer , Ivy Peng

State space models (SSMs) have recently emerged as a powerful framework for long sequence processing, outperforming traditional methods on diverse benchmarks. Fundamentally, SSMs can generalize both recurrent and convolutional networks and…

Signal Processing · Electrical Eng. & Systems 2025-12-24 Xiaoyu Zhang , Mingtao Hu , Sen Lu , Soohyeon Kim , Eric Yeu-Jer Lee , Yuyang Liu , Wei D. Lu

A school of thought contends that human decision making exhibits quantum-like logic. While it is not known whether the brain may indeed be driven by actual quantum mechanisms, some researchers suggest that the decision logic is…

Quantum Physics · Physics 2020-04-10 Alex Bocharov , Michael Freedman , Eshan Kemp , Martin Roetteler , Krysta M. Svore

In the quest for knowledge about how to make good process models, recent research focus is shifting from studying the quality of process models to studying the process of process modeling (often abbreviated as PPM) itself. This paper…

Software Engineering · Computer Science 2015-11-13 Jan Claes , Irene Vanderfeesten , Jakob Pinggera , Hajo A. Reijers , Barbara Weber , Geert Poels

Memory performance is often the main bottleneck in modern computing systems. In recent years, researchers have attempted to scale the memory wall by leveraging new technology such as CXL, HBM, and in- and near-memory processing. Developers…

Performance · Computer Science 2024-11-20 Ashwin Poduval , Hayden Coffey , Michael Swift

Item response theory (IRT) models typically rely on a normality assumption for subject-specific latent traits, which is often unrealistic in practice. Semiparametric extensions based on Dirichlet process mixtures offer a more flexible…

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