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Statistical modeling of fMRI data is challenging as the data are both spatially and temporally correlated. Spatially, measurements are taken at thousands of contiguous regions, called voxels, and temporally measurements are taken at…

Computation · Statistics 2017-10-05 Ming Teng , Farouk S. Nathoo , Timothy D. Johnson

Neuroradiologists and neurosurgeons increasingly opt to use functional magnetic resonance imaging (fMRI) to map functionally relevant brain regions for noninvasive presurgical planning and intraoperative neuronavigation. This application…

Methodology · Statistics 2023-06-07 Andrew S. Whiteman , Andreas J. Bartsch , Jian Kang , Timothy D. Johnson

Magnetic resonance imaging (MRI) plays a vital role in the scientific investigation and clinical management of multiple sclerosis. Analyses of binary multiple sclerosis lesion maps are typically "mass univariate" and conducted with standard…

Bayesian whole-brain functional magnetic resonance imaging (fMRI) analysis with three-dimensional spatial smoothing priors has been shown to produce state-of-the-art activity maps without pre-smoothing the data. The proposed inference…

Methodology · Statistics 2020-10-02 Per Sidén , Finn Lindgren , David Bolin , Anders Eklund , Mattias Villani

Objective: Organ deformation models have the potential to improve delivery and reduce toxicity of radiotherapy, but existing data-driven motion models are based on either patient-specific or population data. We propose to combine population…

In recent years, neuroimaging has undergone a paradigm shift, moving away from the traditional brain mapping approach toward developing integrated, multivariate brain models that can predict categories of mental events. However, large…

Applications · Statistics 2022-09-19 Guoqing Wang , Abhirup Datta , Martin A. Lindquist

To date, we have seen the emergence of a large literature on multivariate disease mapping. That is, incidence of (or mortality from) multiple diseases is recorded at the scale of areal units where incidence (mortality) across the diseases…

Methodology · Statistics 2026-04-17 Garazi Retegui , María Dolores Ugarte , Jaione Etxeberria , Alan E. Gelfand

Functional Magnetic Resonance Imaging (fMRI) relies on multi-step data processing pipelines to accurately determine brain activity; among them, the crucial step of spatial smoothing. These pipelines are commonly suboptimal, given the local…

Computer Vision and Pattern Recognition · Computer Science 2017-10-03 Albert Vilamala , Kristoffer Hougaard Madsen , Lars Kai Hansen

Suppose one is faced with the challenge of tissue segmentation in MR images, without annotators at their center to provide labeled training data. One option is to go to another medical center for a trained classifier. Sadly, tissue…

Machine Learning · Statistics 2019-08-28 Wouter M. Kouw , Silas N. Ørting , Jens Petersen , Kim S. Pedersen , Marleen de Bruijne

Functional connectivity (FC) derived from resting-state fMRI plays a critical role in personalized predictions such as age and cognitive performance. However, applying foundation models(FM) to fMRI data remains challenging due to its high…

Neurons and Cognition · Quantitative Biology 2025-08-26 Yanwen Wang , Xinglin Zhao , Yijin Song , Xiaobo Liu , Yanrong Hao , Rui Cao , Xin Wen

In this work, we present an additive model for space-time data that splits the data into a temporally correlated component and a spatially correlated component. We model the spatially correlated portion using a time-varying Gaussian…

Methodology · Statistics 2017-11-13 Kristjan Greenewald , Seyoung Park , Shuheng Zhou , Alexander Giessing

The partially separable functions (PSF) model is commonly adopted in dynamic MRI reconstruction, as is the underlying signal model in many reconstruction methods including the ones relying on low-rank assumptions. Even though the PSF model…

Image and Video Processing · Electrical Eng. & Systems 2026-01-21 Rodrigo A. Lobos , Xiaokai Wang , Rex T. L. Fung , Yongli He , David Frey , Dinank Gupta , Zhongming Liu , Jeffrey A. Fessler , Douglas C. Noll

Task functional magnetic resonance imaging (fMRI) is a type of neuroimaging data used to identify areas of the brain that activate during specific tasks or stimuli. These data are conventionally modeled using a massive univariate approach…

Methodology · Statistics 2022-11-04 Daniel A. Spencer , David Bolin , Amanda F. Mejia

Functional magnetic resonance imaging (fMRI) has provided invaluable insight into our understanding of human behavior. However, large inter-individual differences in both brain anatomy and functional localization after anatomical alignment…

Applications · Statistics 2021-11-03 Guoqing Wang , Abhirup Datta , Martin A. Lindquist

Spatial documentation is exponentially increasing given the availability of Big IoT Data, enabled by the devices miniaturization and data storage capacity. Bayesian spatial statistics is a useful statistical tool to determine the dependence…

Methodology · Statistics 2020-10-01 Francisco Louzada , Diego C. Nascimento , Osafu Augustine Egbon

This paper asks whether integrating multimodal EEG and fMRI data offers a better characterisation of functional brain architectures than either modality alone. This evaluation rests upon a dynamic causal model that generates both EEG and…

Quantitative Methods · Quantitative Biology 2019-06-19 Huilin Wei , Amirhossein Jafarian , Peter Zeidman , Vladimir Litvak , Adeel Razi , Dewen Hu , Karl J. Friston

In recent years, Bayesian statistics methods in neuroscience have been showing important advances. In particular, detection of brain signals for studying the complexity of the brain is an active area of research. Functional magnetic…

Methodology · Statistics 2017-06-06 Jairo Alberto Fuquene Patiño , Brenda Betancourt , João B. M. Pereira

Stochastic process models for spatiotemporal data underlying random fields find substantial utility in a range of scientific disciplines. Subsequent to predictive inference on the values of the random field (or spatial surface indexed…

Methodology · Statistics 2024-07-26 Aritra Halder , Didong Li , Sudipto Banerjee

Motivated by the needs of selecting important features for massive neuroimaging data, we propose a spatially varying coefficient model (SVCMs) with sparsity and piecewise smoothness imposed on the coefficient functions. A new class of…

Methodology · Statistics 2015-05-01 Ran Shi , Jian Kang

We describe a diffeomorphic registration algorithm that allows groups of images to be accurately aligned to a common space, which we intend to incorporate into the SPM software. The idea is to perform inference in a probabilistic graphical…

Computer Vision and Pattern Recognition · Computer Science 2021-05-10 Mikael Brudfors , Yaël Balbastre , Guillaume Flandin , Parashkev Nachev , John Ashburner
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