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This study is a first step towards using data-informed differential models to predict and control the dynamics of cancer-on-chip experiments. We consider a conceptualized one-dimensional device, containing a cancer and a population of white…

Computational Engineering, Finance, and Science · Computer Science 2026-02-06 Silvia Bertoluzza , Vittoria Bianchi , Gabriella Bretti , Lorenzo Tamellini , Pietro Zanotti

This paper is concerned with the problem of stochastic control of gene regulatory networks (GRNs) observed indirectly through noisy measurements and with uncertainty in the intervention inputs. The partial observability of the gene states…

Molecular Networks · Quantitative Biology 2017-02-27 Mahdi Imani , Ulisses Braga-Neto

Biological structure and function depend on complex regulatory interactions between many genes. A wealth of gene expression data is available from high-throughput genome-wide measurement technologies, but effective gene regulatory network…

Molecular Networks · Quantitative Biology 2016-03-28 Arwen Vanice Bradley , Ye Henry Li , Bokyung Choi , Wing Hung Wong

More than 23 million people are suffered by Heart failure worldwide. Despite the modern transplant operation is well established, the lack of heart donations becomes a big restriction on transplantation frequency. With respect to this…

Fluid Dynamics · Physics 2017-06-29 Chen Song , Vincent Heuveline

In the study of gas dynamics, theoretical modeling and numerical simulation are mostly set up with deterministic settings. Given the coarse-grained modeling in theories of fluids, considerable uncertainties may exist between flow-field…

Computational Physics · Physics 2020-08-07 Tianbai Xiao

We study the steady-state Navier-Stokes equations in the context of stochastic finite element discretizations. Specifically, we assume that the viscosity is a random field given in the form of a generalized polynomial chaos expansion. For…

Numerical Analysis · Mathematics 2016-04-26 Bedřich Sousedík , Howard C. Elman

Gene expression is a fundamental process in a living system. The small RNAs (sRNAs) is widely observed as a global regulator in gene expression. The inherent nonlinearity in this regulatory process together with the bursty production of…

Molecular Networks · Quantitative Biology 2021-10-12 Shigang Qiu , Tao Jia

Generalized polynomial chaos (gPC) method has been extensively used in uncertainty quantification problems where equations contain random variables. For gPC to achieve high accuracy, PDE solutions need to have high regularity in the random…

Numerical Analysis · Mathematics 2020-09-30 Qin Li , Jian-Guo Liu , Ruiwen Shu

We investigate the propagation of uncertainties in the Aw-Rascle-Zhang model, which belongs to a class of second order traffic flow models described by a system of nonlinear hyperbolic equations. The stochastic quantities are expanded in…

Numerical Analysis · Mathematics 2021-05-06 Stephan Gerster , Michael Herty , Elisa Iacomini

We investigate a numerical behaviour of robust deterministic optimal control problem subject to a convection diffusion equation containing uncertain inputs. Stochastic Galerkin approach, turning the original optimization problem containing…

Numerical Analysis · Mathematics 2023-03-01 Pelin Çiloğlu , Hamdullah Yücel

We consider the effect of multiple stochastic parameters on the time-average quantities of chaotic systems. We employ the recently proposed \cite{Kantarakias_Papadakis_2023} sensitivity-enhanced generalized polynomial chaos expansion,…

Chaotic Dynamics · Physics 2023-11-02 George Papadakis , Kyriakos D. Kantarakias

Gaseous flows show a diverse set of behaviors on different characteristic scales. Given the coarse-grained modeling in theories of fluids, considerable uncertainties may exist between the flow-field solutions and the real physics. To study…

Computational Physics · Physics 2021-05-05 Tianbai Xiao , Martin Frank

In this paper we study model reduction of linear and bilinear quadratic stochastic control problems with parameter uncertainties. Specifically, we consider slow-fast systems with unknown diffusion coefficient and study the convergence of…

Optimization and Control · Mathematics 2021-02-10 Hafida Bouanani , Carsten Hartmann , Omar Kebiri

Intrusive Uncertainty Quantification methods such as stochastic Galerkin are gaining popularity, whereas the classical stochastic Galerkin approach is not ensured to preserve hyperbolicity of the underlying hyperbolic system. We apply a…

Numerical Analysis · Mathematics 2019-12-20 Jakob Dürrwächter , Thomas Kuhn , Fabian Meyer , Louisa Schlachter , Florian Schneider

In this paper the optimal control of flocking models with random inputs is investigated from a numerical point of view. The effect of uncertainty in the interaction parameters is studied for a Cucker-Smale type model using a generalized…

Numerical Analysis · Mathematics 2015-03-03 Giacomo Albi , Lorenzo Pareschi , Mattia Zanella

This paper presents stochastic virtual element methods for propagating uncertainty in linear elastic stochastic problems. We first derive stochastic virtual element equations for 2D and 3D linear elastic problems that may involve…

Numerical Analysis · Mathematics 2023-11-01 Zhibao Zheng , Udo Nackenhorst

We develop a stochastic Galerkin finite element method for nonlinear elasticity and apply it to reinforced concrete members with random material properties. The strategy is based on the modified Newton-Raphson method, which consists of an…

Numerical Analysis · Mathematics 2026-01-14 Mohammad S. Ghavami , Bedřich Sousedík , Hooshang Dabbagh , Morad Ahmadnasab

This article establishes the usefulness of the Smoothness-Increasing Accuracy-Increasing (SIAC) filter for reducing the errors in the mean and variance for a wave equation with uncertain coefficients solved via generalized polynomial chaos…

Numerical Analysis · Mathematics 2025-03-19 Andrés Galindo-Olarte , Jennifer K. Ryan

This paper studies the stability and $\mathcal{H}_{\infty}$ performance analysis problem for linear networked and quantized control systems with both communication delays random packet losses. To deal with the network-induced uncertainties…

Systems and Control · Electrical Eng. & Systems 2021-03-05 Wei Ren , Junlin Xiong

In this paper, we present an approach for designing correct-by-design controllers for cyber-physical systems composed of multiple dynamically interconnected uncertain systems. We consider networked discrete-time uncertain nonlinear systems…

Systems and Control · Electrical Eng. & Systems 2023-09-06 Oliver Schön , Birgit van Huijgevoort , Sofie Haesaert , Sadegh Soudjani