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Development of fast methods to conduct in silico experiments using computational models of cellular signaling is a promising approach toward advances in personalized medicine. However, software-based cellular network simulation has…

Molecular Networks · Quantitative Biology 2018-11-20 Kevin Gilboy , Khaled Sayed , Niteesh Sundaram , Kara Bocan , Natasa Miskov-Zivanov

Next-generation supercomputers will feature more hierarchical and heterogeneous memory systems with different memory technologies working side-by-side. A critical question is whether at large scale existing HPC applications and emerging…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-04-27 Ivy Bo Peng , Stefano Markidis , Erwin Laure , Gokcen Kestor , Roberto Gioiosa

Most parallel applications suffer from load imbalance, a crucial performance degradation factor. In particle simulations, this is mainly due to the migration of particles between processing elements, which eventually gather unevenly and…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-08-26 Anthony Boulmier , Nabil Abdennadher , Bastien Chopard

This study addresses the challenge of simulating realistic particle systems by proposing a novel particle decomposition scheme that improves the parallel performance of surface resolved particle simulations. Realistic particle systems often…

Fluid Dynamics · Physics 2024-03-21 J. E. Marquardt , N. Hafen , M. J. Krause

High-quality computational and data-intensive (CDI) applications are critical for advancing research frontiers in almost all disciplines. Despite their importance, there is a significant gap due to the lack of comprehensive best practices…

Computational Engineering, Finance, and Science · Computer Science 2024-06-05 Parinaz Barakhshan , Rudolf Eigenmann

When building Deep Learning (DL) models, data scientists and software engineers manage the trade-off between their accuracy, or any other suitable success criteria, and their complexity. In an environment with high computational power, a…

Machine Learning · Computer Science 2021-03-15 Roger Creus Castanyer , Silverio Martínez-Fernández , Xavier Franch

Studying the reliability of complex systems using machine learning techniques involves facing a series of technical and practical challenges, ranging from the intrinsic nature of the system and data to the difficulties in modeling and…

Machine Learning · Computer Science 2024-10-08 Maria Luz Gamiz , Fernando Navas-Gomez , Rafael Nozal-Cañadas , Rocio Raya-Miranda

The rapid evolution of Large Language Models (LLMs) has markedly expanded their application across diverse domains, transforming how complex problems are approached and solved. Initially conceived to predict subsequent words in texts, these…

Artificial Intelligence · Computer Science 2024-07-11 Sumedh Rasal , E. J. Hauer

CFD users of supercomputers usually resort to rule-of-thumb methods to select the number of subdomains (partitions) when relying on MPI-based parallelization. One common approach is to set a minimum number of elements or cells per…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-06-30 G. Houzeaux , R. M. Badia , R. Borrell , D. Dosimont , J. Ejarque , M. Garcia-Gasulla , V. López

Big data powered Deep Learning (DL) and its applications have blossomed in recent years, fueled by three technological trends: a large amount of digitized data openly accessible, a growing number of DL software frameworks in open source and…

Performance · Computer Science 2019-08-20 Yanzhao Wu , Ling Liu , Calton Pu , Wenqi Cao , Semih Sahin , Wenqi Wei , Qi Zhang

Due to decelerating gains in single-core CPU performance, computationally expensive simulations are increasingly executed on highly parallel hardware platforms. Agent-based simulations, where simulated entities act with a certain degree of…

Multiagent Systems · Computer Science 2018-07-04 Jiajian Xiao , Philipp Andelfinger , David Eckhoff , Wentong Cai , Alois Knoll

Today high-performance computing (HPC) platforms are still dominated by batch jobs. Accordingly, effective batch job scheduling is crucial to obtain high system efficiency. Existing HPC batch job schedulers typically leverage heuristic…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-09-03 Di Zhang , Dong Dai , Youbiao He , Forrest Sheng Bao , Bing Xie

For many applications of pulsed radiation, the time-history of the radiation intensity must be optimized to induce a desired time-history of conditions. This optimization is normally performed using multi-physics simulations of the system.…

Computational Physics · Physics 2019-03-14 Damian C. Swift , George B. Zimmerman

Neural population activity exhibits complex, nonlinear dynamics, varying in time, over trials, and across experimental conditions. Here, we develop Conditionally Linear Dynamical System (CLDS) models as a general-purpose method to…

Neurons and Cognition · Quantitative Biology 2025-10-31 Victor Geadah , Amin Nejatbakhsh , David Lipshutz , Jonathan W. Pillow , Alex H. Williams

Simulations play a crucial role in the modern scientific process. Yet despite (or due to) this ubiquity, the Data Science community shares neither a comprehensive definition for a "high-quality" study nor a consolidated guide to designing…

Computation · Statistics 2025-05-16 Corrine F Elliott , James PC Duncan , Tiffany M Tang , Merle Behr , Karl Kumbier , Bin Yu

We study the problem of optimal incentive design for voluntary participation of electricity customers in a Direct Load Scheduling (DLS) program, a new form of Direct Load Control (DLC) based on a three way communication protocol between…

Systems and Control · Computer Science 2013-10-02 Mahnoosh Alizadeh , Yuanzhang Xiao , Anna Scaglione , Mihaela van der Schaar

Taking advantage of their data-driven and model-free features, Deep Reinforcement Learning (DRL) algorithms have the potential to deal with the increasing level of uncertainty due to the introduction of renewable-based generation. To deal…

Systems and Control · Electrical Eng. & Systems 2022-08-02 Hou Shengren , Edgar Mauricio Salazar , Pedro P. Vergara , Peter Palensky

The cloud datacenter has numerous hosts as well as application requests where resources are dynamic. The demands placed on the resource allocation are diverse. These factors could lead to load imbalances, which affect scheduling efficiency…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-11-07 Sakshi Chhabra , Ashutosh Kumar Singh

Science Data Systems (SDS) handle science data from acquisition through processing to distribution. They are deployed in the Cloud today, and the efficiency of Cloud instance utilization is critical to success. Conventional SDS are unable…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-12-21 Lei Pan , Twinkle Jain

Applications' performance is influenced by the mapping of processes to computing nodes, the frequency and volume of exchanges among processing elements, the network capacity, and the routing protocol. A poor mapping of application processes…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-03-11 Jonas H. Müller Korndörfer , Mario Bielert , Laércio L. Pilla , Florina M. Ciorba
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