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This paper introduces a high-throughput software tool framework called {\it sam2bam} that enables users to significantly speedup pre-processing for next-generation sequencing data. The sam2bam is especially efficient on single-node…

Genomics · Quantitative Biology 2017-02-08 Takeshi Ogasawara , Yinhe Cheng , Tzy-Hwa Kathy Tzeng

Bloom Filter is a probabilistic membership data structure and it is excessively used data structure for membership query. Bloom Filter becomes the predominant data structure in approximate membership filtering. Bloom Filter extremely…

Data Structures and Algorithms · Computer Science 2019-04-01 Ripon Patgiri , Sabuzima Nayak , Samir Kumar Borgohain

Database management systems (DBMSs) carefully optimize complex multi-join queries to avoid expensive disk I/O. As servers today feature tens or hundreds of gigabytes of RAM, a significant fraction of many analytic databases becomes…

Databases · Computer Science 2015-07-22 Feilong Liu , Spyros Blanas

Motivation: Illumina DNA sequencing is now the predominant source of raw genomic data, and data volumes are growing rapidly. Bioinformatic analysis pipelines are having trouble keeping pace. A common bottleneck in such pipelines is the…

Genomics · Quantitative Biology 2014-09-09 Gregory G. Faust , Ira M. Hall

Modern key-value stores rely heavily on Log-Structured Merge (LSM) trees for write optimization, but this design introduces significant read amplification. Auxiliary structures like Bloom filters help, but impose memory costs that scale…

Data Structures and Algorithms · Computer Science 2025-08-05 Nicholas Fidalgo , Puyuan Ye

Clustering is a fundamental tool in unsupervised learning, used to group objects by distinguishing between similar and dissimilar features of a given data set. One of the most common clustering algorithms is k-means. Unfortunately, when…

Machine Learning · Statistics 2021-08-17 Olga Dorabiala , J. Nathan Kutz , Aleksandr Aravkin

The success of deep learning in supervised fine-grained recognition for domain-specific tasks relies heavily on expert annotations. The Open-Set for fine-grained Self-Supervised Learning (SSL) problem aims to enhance performance on…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Prajwal Singh , Gautam Vashishtha , Indra Deep Mastan , Shanmuganathan Raman

In a standard setting of Bayesian optimization (BO), the objective function evaluation is assumed to be highly expensive. Multi-fidelity Bayesian optimization (MFBO) accelerates BO by incorporating lower fidelity observations available with…

In many modern LLM applications, such as retrieval augmented generation, prompts have become programs themselves. In these settings, prompt programs are repeatedly called with different user queries or data instances. A big practical…

Computation and Language · Computer Science 2024-07-01 Tobias Schnabel , Jennifer Neville

Deep learning for recommendation data is one of the most pervasive and challenging AI workload in recent times. State-of-the-art recommendation models are one of the largest models matching the likes of GPT-3 and Switch Transformer.…

Information Retrieval · Computer Science 2022-01-25 Aditya Desai , Li Chou , Anshumali Shrivastava

Filters such as Bloom, quotient, and cuckoo filters are fundamental building blocks providing space-efficient approximate set membership testing. However, many applications need to associate small values with keys-functionality that filters…

Data Structures and Algorithms · Computer Science 2025-10-08 Michael A. Bender , Alex Conway , Martín Farach-Colton , Rob Johnson , Prashant Pandey

Bloom filters are a fundamental data structure for approximate membership queries, with applications ranging from data analytics to databases and genomics. Several variants have been proposed to accommodate parallel architectures. GPUs,…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-18 Daniel Jünger , Kevin Kristensen , Yunsong Wang , Xiangyao Yu , Bertil Schmidt

Writing concurrent programs for shared memory multiprocessor systems is a nightmare. This hinders users to exploit the full potential of multiprocessors. STM (Software Transactional Memory) is a promising concurrent programming paradigm…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-07-27 Ajay Singh , Sathya Peri , G Monika , Anila Kumari

Standard Bayesian Optimization (BO) assumes uniform smoothness across the search space an assumption violated in multi-regime problems such as molecular conformation search through distinct energy basins or drug discovery across…

Machine Learning · Computer Science 2026-01-29 Yan Zhang , Xuefeng Liu , Sipeng Chen , Sascha Ranftl , Chong Liu , Shibo Li

Motivation: Building the histogram of occurrences of every $k$-symbol long substring of nucleotide data is a standard step in many bioinformatics applications, known under the name of $k$-mer counting. Its applications include developing de…

Data Structures and Algorithms · Computer Science 2017-03-03 Sebastian Deorowicz , Marek Kokot , Szymon Grabowski , Agnieszka Debudaj-Grabysz

We show how to answer spatial multiple-set intersection queries in O(n(log w)/w + kt) expected time, where n is the total size of the t sets involved in the query, w is the number of bits in a memory word, k is the output size, and c is any…

Data Structures and Algorithms · Computer Science 2017-08-31 Michael T. Goodrich

Set queries are fundamental operations in computer systems and applications.This paper addresses the fundamental problem of designing a probabilistic data structure that can quickly process set queries using a small amount of memory. We…

Data Structures and Algorithms · Computer Science 2016-03-23 Tong Yang , Alex X. Liu , Muhammad Shahzad , Yuankun Zhong , Qiaobin Fu , Zi Li , Gaogang Xie , Xiaoming Li

Restricted Boltzmann Machines (RBMs) are powerful tools for modeling complex systems and extracting insights from data, but their training is hindered by the slow mixing of Markov Chain Monte Carlo (MCMC) processes, especially with highly…

Machine Learning · Computer Science 2025-12-09 Nicolas Béreux , Aurélien Decelle , Cyril Furtlehner , Lorenzo Rosset , Beatriz Seoane

Some transformer attention heads appear to function as membership testers, dedicating themselves to answering the question "has this token appeared before in the context?" We identify these heads across four language models (GPT-2 small,…

Machine Learning · Computer Science 2026-02-20 Peter Balogh

State Machine Replication (SMR) is a fundamental approach to designing service with fault tolerance. However, its requirement for the deterministic execution of transactions often results in single-threaded replicas, which cannot fully…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-11-27 Gang Wu1 , Guodong Zhao , Yidong Song