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Stochastic modelling provides an indispensable tool for understanding how random events at the molecular level influence cellular functions. In practice, the common challenge is to calibrate a large number of model parameters against the…

Molecular Networks · Quantitative Biology 2015-03-17 Shuohao Liao , Tomas Vejchodsky , Radek Erban

We present computer-assisted methods for analyzing stochastic models of gene regulatory networks. The main idea that underlies this equation-free analysis is the design and execution of appropriately-initialized short bursts of stochastic…

Biological Physics · Physics 2009-11-11 Radek Erban , Ioannis G. Kevrekidis , David Adalsteinsson , Timothy C. Elston

High-dimensional tensor-valued predictors arise in modern applications, increasingly as learned representations from neural networks. Existing tensor classification methods rely on sparsity or Tucker structures and often lack theoretical…

Machine Learning · Computer Science 2025-12-16 Elynn Chen , Yuefeng Han , Jiayu Li

This paper describes a flexible framework for generalized low-rank tensor estimation problems that includes many important instances arising from applications in computational imaging, genomics, and network analysis. The proposed estimator…

Statistics Theory · Mathematics 2021-02-08 Rungang Han , Rebecca Willett , Anru R. Zhang

Tensor trains are a versatile tool to compress and work with high-dimensional data and functions. In this work we introduce the Streaming Tensor Train Approximation (STTA), a new class of algorithms for approximating a given tensor…

Numerical Analysis · Mathematics 2022-08-05 Daniel Kressner , Bart Vandereycken , Rik Voorhaar

Many cellular behaviors are regulated by gene regulation networks, kinetics of which is one of the main subjects in the study of systems biology. Because of the low number molecules in these reacting systems, stochastic effects are…

Quantitative Methods · Quantitative Biology 2011-04-26 Jinzhi Lei

In biophysics, the search for analytical solutions of stochastic models of cellular processes is often a challenging task. In recent work on models of gene expression, it was shown that a mapping based on partitioning of Poisson arrivals…

Biological Physics · Physics 2018-05-09 Hugo Tschirhart , Thierry Platini

Tensor networks such as matrix product states (MPS) and projected entangled pair states (PEPS) are commonly used to approximate quantum systems. These networks are optimized in methods such as DMRG or evolved by local operators. We provide…

Numerical Analysis · Mathematics 2020-01-07 Yifan Zhang , Edgar Solomonik

We propose a novel sparse tensor decomposition method, namely Tensor Truncated Power (TTP) method, that incorporates variable selection into the estimation of decomposition components. The sparsity is achieved via an efficient truncation…

Machine Learning · Statistics 2016-05-04 Will Wei Sun , Junwei Lu , Han Liu , Guang Cheng

This paper introduces a general framework of Semi-parametric TEnsor Factor Analysis (STEFA) that focuses on the methodology and theory of low-rank tensor decomposition with auxiliary covariates. Semi-parametric TEnsor Factor Analysis models…

Methodology · Statistics 2024-04-03 Elynn Y. Chen , Dong Xia , Chencheng Cai , Jianqing Fan

Deciphering complex gene-gene interactions remains challenging in transcriptomics as traditional methods often miss higher-order and nonlinear dependencies. This study introduces a quantum-inspired framework leveraging tensor networks (TNs)…

Molecular Networks · Quantitative Biology 2025-09-09 Olatz Sanz Larrarte , Borja Aizpurua , Reza Dastbasteh , Ruben M. Otxoa , Josu Etxezarreta Martinez

We study the Order-$k$ ($k \geq 4$) spiked tensor model for the tensor principal component analysis (PCA) problem: given $N$ i.i.d. observations of a $k$-th order tensor generated from the model $\mathbf{T} = \lambda \cdot v_*^{\otimes k} +…

Optimization and Control · Mathematics 2025-10-17 Shihong Ding , Yihong Gu , Yuanshi Liu , Cong Fang

We study the application of the novel tensor formats (TT, QTT, QTT-Tucker) to the solution of $d$-dimensional chemical master equations, applied mostly to gene regulating networks (signaling cascades, toggle switches, phage-$\lambda$). For…

Numerical Analysis · Mathematics 2013-11-14 Sergey Dolgov , Boris Khoromskij

High-dimensional tensors or multi-way data are becoming prevalent in areas such as biomedical imaging, chemometrics, networking and bibliometrics. Traditional approaches to finding lower dimensional representations of tensor data include…

Machine Learning · Statistics 2012-02-14 Genevera I. Allen

Modeling joint probability distributions over sequences has been studied from many perspectives. The physics community developed matrix product states, a tensor-train decomposition for probabilistic modeling, motivated by the need to…

Machine Learning · Computer Science 2020-10-22 Siddarth Srinivasan , Sandesh Adhikary , Jacob Miller , Guillaume Rabusseau , Byron Boots

Statistical inference for tensors has emerged as a critical challenge in analyzing high-dimensional data in modern data science. This paper introduces a unified framework for inferring general and low-Tucker-rank linear functionals of…

Statistics Theory · Mathematics 2025-01-28 Ke Xu , Elynn Chen , Yuefeng Han

In this work, we perform Bayesian inference tasks for the chemical master equation in the tensor-train format. The tensor-train approximation has been proven to be very efficient in representing high dimensional data arising from the…

There has been an increasing demand for formal methods in the design process of safety-critical synthetic genetic circuits. Probabilistic model checking techniques have demonstrated significant potential in analyzing the intrinsic…

Emerging Technologies · Computer Science 2019-01-24 Thakur Neupane , Zhen Zhang , Curtis Madsen , Hao Zheng , Chris J. Myers

Online transient stability assessment (TSA) is essential for secure and stable power system operations. The growing number of Phasor Measurement Units (PMUs) brings about massive sources of data that can enhance online TSA. However,…

Systems and Control · Electrical Eng. & Systems 2021-12-16 Rui Ma , Sara Eftekharnejad , Chen Zhong , Mustafa Cenk Gursoy

Tensor train is a hierarchical tensor network structure that helps alleviate the curse of dimensionality by parameterizing large-scale multidimensional data via a set of network of low-rank tensors. Associated with such a construction is a…

Machine Learning · Computer Science 2018-03-15 Wenqi Wang , Vaneet Aggarwal , Shuchin Aeron
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