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Assessing heterogeneous treatment effects has become a growing interest in advancing precision medicine. Individualized treatment effects (ITE) play a critical role in such an endeavor. Concerning experimental data collected from randomized…

Machine Learning · Statistics 2018-07-23 Xiaogang Su , Annette T. Peña , Lei Liu , Richard A. Levine

Genomics has revolutionized biology, enabling the interrogation of whole transcriptomes, genome-wide binding sites for proteins, and many other molecular processes. However, individual genomic assays measure elements that interact in vivo…

Machine Learning · Statistics 2022-06-08 Sumanta Basu , Karl Kumbier , James B. Brown , Bin Yu

Random Forest (RF) is a widely used ensemble learning technique known for its robust classification performance across diverse domains. However, it often relies on hundreds of trees and all input features, leading to high inference cost and…

Machine Learning · Computer Science 2025-07-08 Sijan Bhattarai , Saurav Bhandari , Girija Bhusal , Saroj Shakya , Tapendra Pandey

Precision medicine provides customized treatments to patients based on their characteristics and is a promising approach to improving treatment efficiency. Large scale omics data are useful for patient characterization, but often their…

Machine Learning · Statistics 2023-01-24 Jianchang Hu , Silke Szymczak

Random forests are a type of ensemble method which makes predictions by combining the results of several independent trees. However, the theory of random forests has long been outpaced by their application. In this paper, we propose a novel…

Machine Learning · Computer Science 2015-07-23 Jianyuan Sun , Guoqiang Zhong , Junyu Dong , Yajuan Cai

Feature and Interaction Importance (FII) methods are essential in supervised learning for assessing the relevance of input variables and their interactions in complex prediction models. In many domains, such as personalized medicine, local…

Machine Learning · Statistics 2025-12-15 Kata Vuk , Nicolas Alexander Ihlo , Merle Behr

Random forest (RF) stands out as a highly favored machine learning approach for classification problems. The effectiveness of RF hinges on two key factors: the accuracy of individual trees and the diversity among them. In this study, we…

Machine Learning · Computer Science 2024-10-28 Ye-eun Kim , Seoung Yun Kim , Hyunjoong Kim

Precision medicine is an evolving area in the medical field and rely on biomarkers to make patient enrichment decisions, thereby providing drug development direction. A traditional statistical approach is to find the cut-off that leads to…

Methodology · Statistics 2025-04-14 Gina D'Angelo , Xiaowen Tian , Chuyu Deng , Xian Zhou

Label ranking aims to learn a mapping from instances to rankings over a finite number of predefined labels. Random forest is a powerful and one of the most successful general-purpose machine learning algorithms of modern times. In this…

Machine Learning · Computer Science 2018-06-19 Yangming Zhou , Guoping Qiu

Random Forest (RF) is a well-known data-driven algorithm applied in several fields thanks to its flexibility in modeling the relationship between the response variable and the predictors, also in case of strong non-linearities. In…

Machine Learning · Statistics 2023-10-18 Luca Patelli , Michela Cameletti , Natalia Golini , Rosaria Ignaccolo

Random forests is a state-of-the-art supervised machine learning method which behaves well in high-dimensional settings although some limitations may happen when $p$, the number of predictors, is much larger than the number of observations…

Methodology · Statistics 2019-02-01 Louis Capitaine , Robin Genuer , Rodolphe Thiébaut

Random forest is a popular machine learning approach for the analysis of high-dimensional data because it is flexible and provides variable importance measures for the selection of relevant features. However, the complex relationships…

Machine Learning · Computer Science 2023-08-07 Lucas F. Voges , Lukas C. Jarren , Stephan Seifert

The random forest algorithm, proposed by L. Breiman in 2001, has been extremely successful as a general-purpose classification and regression method. The approach, which combines several randomized decision trees and aggregates their…

Statistics Theory · Mathematics 2015-11-19 Gérard Biau , Erwan Scornet

This paper examines from an experimental perspective random forests, the increasingly used statistical method for classification and regression problems introduced by Leo Breiman in 2001. It first aims at confirming, known but sparse,…

Machine Learning · Statistics 2008-11-24 Robin Genuer , Jean-Michel Poggi , Christine Tuleau

In the fight against hard-to-treat diseases such as cancer, it is often difficult to discover new treatments that benefit all subjects. For regulatory agency approval, it is more practical to identify subgroups of subjects for whom the…

Methodology · Statistics 2014-10-09 Wei-Yin Loh , Xu He , Michael Man

Random forests (RFs) are widely used for prediction and variable importance analysis and are often believed to capture any types of interactions via recursive splitting. However, since the splits are chosen locally, interactions are only…

Methodology · Statistics 2026-01-13 Roman Hornung , Alexander Hapfelmeier

Classification is essential to the applications in the field of data mining, artificial intelligence, and fault detection. There exists a strong need in developing accurate, suitable, and efficient classification methods and algorithms with…

Artificial Intelligence · Computer Science 2024-03-19 Yingtao Ren , Xiaomin Zhu , Kaiyuan Bai , Runtong Zhang

Random Forests are widely claimed to capture interactions well. However, some simple examples suggest that they perform poorly in the presence of certain pure interactions that the conventional CART criterion struggles to capture during…

Machine Learning · Statistics 2025-08-04 Ricardo Blum , Munir Hiabu , Enno Mammen , Joseph Theo Meyer

Combining machine learning with econometric analysis is becoming increasingly prevalent in both research and practice. A common empirical strategy involves the application of predictive modeling techniques to 'mine' variables of interest…

Econometrics · Economics 2020-12-22 Mochen Yang , Edward McFowland , Gordon Burtch , Gediminas Adomavicius

Automated high-stake decision-making such as medical diagnosis requires models with high interpretability and reliability. As one of the interpretable and reliable models with good prediction ability, we consider Sparse High-order…

Machine Learning · Statistics 2021-06-10 Diptesh Das , Vo Nguyen Le Duy , Hiroyuki Hanada , Koji Tsuda , Ichiro Takeuchi
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