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The key to dynamic or multi-contrast magnetic resonance imaging (MRI) reconstruction lies in exploring inter-frame or inter-contrast information. Currently, the unrolled model, an approach combining iterative MRI reconstruction steps with…
Confocal laser-scanning microscopy (CLSM) is one of the most popular optical architectures for fluorescence imaging. In CLSM, a focused laser beam excites the fluorescence emission from a specific specimen position. Some actuators scan the…
We consider an inverse transport problem in fluorescence ultrasound modulated optical tomography (fUMOT) with angularly averaged illuminations and measurements. We study the uniqueness and stability of the reconstruction of the absorption…
Functional Magnetic Resonance Imaging (fMRI) is a neuroimaging technique with pivotal importance due to its scientific and clinical applications. As with any widely used imaging modality, there is a need to ensure the quality of the same,…
Full Waveform Inversion (FWI) is a powerful wave-based imaging technique, but its inherent ill-posedness and non-convexity lead to local minima and poor convergence. Regularization methods stabilize FWI by incorporating prior information…
To overcome the physical barriers caused by light diffraction, super-resolution techniques are often applied in fluorescence microscopy. State-of-the-art approaches require specific and often demanding acquisition conditions to achieve…
Photo-acoustic Tomography (PAT) and Thermo-acoustic Tomography (TAT) are medical imaging modalities that combine the high contrast of radiative properties of tissues with the high resolution of ultrasound. In both modalities, a first step…
PURPOSE: We develop a practical, iterative algorithm for image-reconstruction in under-sampled tomographic systems, such as digital breast tomosynthesis (DBT). METHOD: The algorithm controls image regularity by minimizing the image total…
We consider the problem of reconstructing 2D images from randomly under-sampled confocal microscopy samples. The well known and widely celebrated total variation regularization, which is the L1 norm of derivatives, turns out to be…
Diffuse optical breast imaging utilizes near-infrared (NIR) light propagation through tissues to assess the optical properties of tissue for the identification of abnormal tissue. This optical imaging approach is sensitive, cost-effective,…
Fluorescence fluctuations-based super-resolution microscopy (FF-SRM) is an emerging field promising low-cost and live-cell compatible imaging beyond the resolution of conventional optical microscopy. A comprehensive overview on how the…
Fluorescence microscopy (FM) imaging is a fundamental technique for observing live cell division, one of the most essential processes in the cycle of life and death. Observing 3D live cells requires scanning through the cell volume while…
Tuning the regularization hyperparameter $\alpha$ in inverse problems has been a longstanding problem. This is particularly true in the case of fetal brain magnetic resonance imaging, where an isotropic high-resolution volume is…
With the advent of multi-coil imaging and compressed sensing, a number of model based reconstruction algorithms have been created. They incorporate a multitude of different regularization functions based on physics, observed phenomenology,…
The Fluorescence detector Array of Single-pixel Telescopes (FAST) is one of several proposed designs for a next-generation cosmic-ray detector. Such detectors will require enormous collecting areas whilst also needing to remain…
Optical Deflectometric Tomography (ODT) provides an accurate characterization of transparent materials whose complex surfaces present a real challenge for manufacture and control. In ODT, the refractive index map (RIM) of a transparent…
Kernelized maximum-likelihood (ML) expectation maximization (EM) methods have recently gained prominence in PET image reconstruction, outperforming many previous state-of-the-art methods. But they are not immune to the problems of…
This paper presents an innovative set of tools to support a methodology for the multichannel interpolation (MCI) of a discrete signal. It is shown that a bandlimited signal $f$ can be exactly reconstructed from finite samples of $g_k$…
Optical-resolution fluorescence imaging through and within complex samples presents a significant challenge due to random light scattering, with substantial implications across multiple fields. While significant advancements in coherent…
The structured illumination microscopy using unknown speckle patterns has shown the capacity to surpass the Abbe's diffraction barrier, giving the possibility to design cheap and versatile SIM devices. However, the state-of-the-art joint…