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Fluorescence Molecular Tomography (FMT) is a promising technique for non-invasive 3D visualization of fluorescent probes, but its reconstruction remains challenging due to the inherent ill-posedness and reliance on inaccurate or…

Image and Video Processing · Electrical Eng. & Systems 2025-11-07 Shihan Zhao , Jianru Zhang , Yanan Wu , Linlin Li , Siyuan Shen , Xingjun Zhu , Guoyan Zheng , Jiahua Jiang , Wuwei Ren

Fluorescence molecular tomography (FMT) is a sensitive optical imaging technology widely used in biomedical research. However, the ill-posedness of the inverse problem poses a huge challenge to FMT reconstruction. Although end-to-end deep…

Image and Video Processing · Electrical Eng. & Systems 2025-03-18 Peng Zhang , Qianqian Xue , Xingyu Liu , Guanglei Zhang , Wenjian Wang , Jiye Liang

Fluorescence molecular tomography (FMT) has potential of providing high contrast images for breast tumor detection. Computational phantom provides a convenient way to a wide variety of fluorophore distribution configurations in patients and…

Medical Physics · Physics 2018-04-02 Yansong Zhu , Abhinav K. Jha , Arman Rahmim

Fluorescence molecular tomography (FMT) is a promising modality for non-invasive imaging of internal fluorescence agents in biological tissues especially in small animal models, with applications in diagnosis, therapy, and drug design. In…

Optics · Physics 2023-08-09 Wenxiang Cong , Ge Wang

Photoacoustic tomography is a hybrid imaging technique that combines high optical tissue contrast with high ultrasound resolution. Direct reconstruction methods such as filtered backprojection, time reversal and least squares suffer from…

We present a reconstruction method involving maximum-likelihood expectation maximization (MLEM) to model Poisson noise as applied to fluorescence molecular tomography (FMT). MLEM is initialized with the output from a sparse…

Medical Physics · Physics 2018-04-03 Yansong Zhu , Abhinav K. Jha , Dean F. Wong , Arman Rahmim

Fluorescence Molecular Tomography (FMT) is a widely used non-invasive optical imaging technology in biomedical research. It usually faces significant accuracy challenges in depth reconstruction, and conventional iterative methods struggle…

Numerical Analysis · Mathematics 2025-10-08 Ruchi Guo , Jiahua Jiang , Bangti Jin , Wuwei Ren , Jianru Zhang

The image reconstruction problem consists in finding an approximation of a function f starting from its Radon transform Rf. This problem arises in the ambit of medical imaging when one tries to reconstruct the internal structure of the…

Numerical Analysis · Mathematics 2011-11-28 Amos Sironi

In this study, we investigate the inverse source problem arising in bioluminescence tomography, the objective of which is to reconstruct both the support and the intensity of an internal light source from boundary measurements governed by…

Numerical Analysis · Mathematics 2025-11-25 Qianqian Wu , Rongfang Gong , Wei Gong , Ziyi Zhang , Shengfeng Zhu

The iterative refinement method (IRM) has been very successfully applied in many different fields for examples the modern quantum chemical calculation and CT image reconstruction. It is proved that the refinement method can create an exact…

Medical Physics · Physics 2015-12-23 Kang Yang , Kevin Yang , Xintie Yang , Shuang-Ren Zhao

One of the advantages of spectral computed tomography (CT) is it can achieve accurate material components using the material decomposition methods. The image-based material decomposition is a common method to obtain specific material…

Image and Video Processing · Electrical Eng. & Systems 2019-10-18 Weiwen Wu , Peijun Chen , Vince Vardhanabhuti , Weifei Wu , Hengyong Yu

Maximum likelihood iteration is one of the most commonly used reconstruction algorithms in quantum tomography. The main appeal of the method is that it is easy to implement and that it converges reliably to a physically meaningful density…

Quantum Physics · Physics 2025-08-21 Florian Oberender

Optical diffraction tomography is an indispensable tool for studying objects in three-dimensions due to its ability to accurately reconstruct scattering objects. Until now this technique has been limited to coherent light because spatial…

We propose a model-based image reconstruction method for photoacoustic tomography(PAT) involving a novel form of regularization and demonstrate its ability to recover good quality images from significantly reduced size datasets. The…

Image and Video Processing · Electrical Eng. & Systems 2020-12-29 Nadaparambil Aravindakshan Rejesh , Sandeep Kumar Kalva , Manojit Pramanik , Muthuvel Arigovindan

With the advent of infrared long-baseline interferometers with more than two telescopes, both the size and the completeness of interferometric data sets have significantly increased, allowing images based on models with no a priori…

Instrumentation and Methods for Astrophysics · Physics 2015-05-28 Stéphanie Renard , Eric Thiébaut , Fabien Malbet

Magnetic Resonance Fingerprinting (MRF) reconstructs tissue maps based on a sequence of very highly undersampled images. In order to be able to perform MRF reconstruction, state-of-the-art MRF methods rely on priors such as the MR physics…

Image and Video Processing · Electrical Eng. & Systems 2020-10-20 Simon Arberet , Xiao Chen , Boris Mailhe , Peter Speier , Gregor Koerzdoerfer , Mathias Nittka , Heiko Meyer , Mariappan S. Nadar

Magnetic resonance fingerprinting (MRF) provides a unique concept for simultaneous and fast acquisition of multiple quantitative MR parameters. Despite acquisition efficiency, adoption of MRF into the clinics is hindered by its dictionary…

Image and Video Processing · Electrical Eng. & Systems 2020-08-11 Fabian Balsiger , Alain Jungo , Olivier Scheidegger , Pierre G. Carlier , Mauricio Reyes , Benjamin Marty

The spatial resolution of images of living samples obtained by fluorescence microscopes is physically limited due to the diffraction of visible light, which makes the study of entities of size less than the diffraction barrier (around 200…

Image and Video Processing · Electrical Eng. & Systems 2023-03-21 Vasiliki Stergiopoulou , Subhadip Mukherjee , Luca Calatroni , Laure Blanc-Féraud

Spectral computed tomography (CT) has a great potential in material identification and decomposition. To achieve high-quality material composition images and further suppress the x-ray beam hardening artifacts, we first propose a one-step…

Computer Vision and Pattern Recognition · Computer Science 2020-01-08 Weiwen Wu , Qian Wang , Fenglin Liu , Yining Zhu , Hengyong Yu

In this work, we propose a new paradigm of iterative model-based reconstruction algorithms for providing real-time solution for zooming-in and refining a region of interest in medical and clinical tomographic images. This algorithmic…

Image and Video Processing · Electrical Eng. & Systems 2025-12-01 Junqi Tang , Guixian Xu , Jinglai Li
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