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During the morphogenesis of tissues and tumors, cells often interact with neighbors with different mechanical properties, but the understanding of its role is lacking. We use active Brownian Dynamics simulations to study a model co-culture…

Soft Condensed Matter · Physics 2021-01-07 Supravat Dey , Moumita Das

Intracellular transport is essential for maintaining proper cellular function in most eukaryotic cells, with perturbations in active transport resulting in several types of disease. Efficient delivery of critical cargos to specific…

Biological Physics · Physics 2016-08-16 David Ando , Nickolay Korabel , Kerwyn Casey Huang , Ajay Gopinathan

Collective cell movement, characterized by multiple cells that are in contact for substantial periods of time and undergo correlated motion, plays a central role in cancer and embryogenesis. Recent imaging experiments have provided…

Biological Physics · Physics 2020-06-03 Sumit Sinha , Abdul N Malmi-Kakkada , Xin Li , Himadri S. Samanta , D. Thirumalai

In this paper, we discuss the transport phenomena of electromagnetic waves in a two-dimensional random system which is composed of arrays of electrical dipoles, following the model presented earlier by Erdogan, et al. (J. Opt. Soc. Am. B…

Soft Condensed Matter · Physics 2009-11-10 Ken Wang , Zhen Ye

We perform molecular dynamics simulations using the extended simple point charge SPC/E water model in order to investigate the dynamical behavior of supercooled-stretched water. We focus on the behavior of the translational diffusion…

Statistical Mechanics · Physics 2007-05-23 P. A. Netz , F. Starr , M. C. Barbosa , H. Eugene Stanley

It is a well known fact that subdiffusion equations in terms of fractional derivatives can be obtained from Continuous Time Random Walk (CTRW) models with long-tailed waiting time distributions. Over the last years various authors have…

Biological Physics · Physics 2010-06-15 S. B. Yuste , E. Abad , K. Lindenberg

Diffusion of tracer particles in the cytoplasm of mammalian cells is often anomalous with a marked heterogeneity even within individual particle trajectories. Despite considerable efforts, the mechanisms behind these observations have…

Biological Physics · Physics 2020-08-05 Adal Sabri , Xinran Xu , Diego Krapf , Matthias Weiss

A packed community of exponentially proliferating microbes will spread in size exponentially. However, due to nutrient depletion, mechanical constraints, or other limitations, exponential proliferation is not indefinite, and the spreading…

Biological Physics · Physics 2026-02-02 Meiyi Yao , Joshua M. Jones , Joseph W. Larkin , Andrew Mugler

A major challenge in flow through porous media is to better understand the link between microstructure and macroscale flow and transport. For idealised microstructures, the mathematical framework of homogenisation theory can be used for…

Lateral diffusion of molecules on surfaces plays a very important role in various biological processes, including lipid transport across the cell membrane, synaptic transmission and other phenomena such as exo- and endocytosis, signal…

Analysis of PDEs · Mathematics 2013-11-12 A. B. Duncan , C. M. Elliott , G. A. Pavliotis , A. M. Stuart

Diffusion in living tissues governs essential physiological processes and is well studied within cells. Yet how extracellular molecular motion emerges from the structural complexity of tissues remains unresolved. In the brain, molecules…

A living cell's interior is one of the most complex and intrinsically dynamic systems, providing an elaborate interplay between cytosolic crowding and ATP-driven motion, which controls cellular functionality. Here, we investigated two…

Biological Physics · Physics 2019-11-14 P. Witzel , M. Götz , Y. Lanoiselée , T. Franosch , D. S. Grebenkov , D. Heinrich

The paper addresses the single-file diffusion in the presence of an absorbing boundary. The emphasis is on an interplay between the hard-core interparticle interaction and the absorption process. The resulting dynamics exhibits several…

Statistical Mechanics · Physics 2014-02-26 Artem Ryabov , Petr Chvosta

A large variety of real systems are composed by entities in relationships which can be represented by networks. In many of these systems, elements are embedded in the space and location information impacts properties and evolution. Local…

Physics and Society · Physics 2021-11-09 Michele Tirico , Stefan Balev , Antoine Dutot , Damien Olivier

Cell membranes phase separate into ordered ${\rm L_o}$ and disordered ${\rm L_d}$ domains depending on their compositions. This membrane compartmentalization is heterogeneous and regulates the localization of specific proteins related to…

Soft Condensed Matter · Physics 2023-08-11 Ken Sakamoto , Takuma Akimoto , Mayu Muramatsu , Mark S. P. Sansom , Ralf Metzler , Eiji Yamamoto

In this article, we propose a general framework to study the dynamics and topology of cellular networks that capture the geometry of cell packings in two-dimensional tissues. Such epithelia undergo large-scale deformation during…

Tissues and Organs · Quantitative Biology 2017-09-08 Matthias Merkel , Raphaël Etournay , Marko Popović , Guillaume Salbreux , Suzanne Eaton , Frank Jülicher

We consider the diffusion-advection problem in two simple cellular flow models (often invoked as examples for subdiffusive tracer's motion) and concentrate on the intermediate time range, in which the tracer's motion indeed may show…

Fluid Dynamics · Physics 2016-09-28 Patrick Pöschke , Igor M. Sokolov , Alexander A. Nepomnyashchy , Michael A. Zaks

Development, regeneration and cancer involve drastic transitions in tissue morphology. In analogy with the behavior of inert fluids, some of these transitions have been interpreted as wetting transitions. The validity and scope of this…

Diffusive transport of small molecules within the internal structures of biological and synthetic material systems is complex because the crowded environment presents chemical and physical barriers to mobility. We explored this mobility…

Soft Condensed Matter · Physics 2020-09-29 Rajarshi Guha , Subhadip Ghosh , Darrell Velegol , Peter J. Butler , Ayusman Sen , Jennifer L. Ross

Human mobility and activity patterns mediate contagion on many levels, including the spatial spread of infectious diseases, diffusion of rumors, and emergence of consensus. These patterns however are often dominated by specific locations…

Physics and Society · Physics 2011-07-05 Duygu Balcan , Alessandro Vespignani