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Deep learning models have exhibited exceptional effectiveness in Computational Pathology (CPath) by tackling intricate tasks across an array of histology image analysis applications. Nevertheless, the presence of out-of-distribution data…

Image and Video Processing · Electrical Eng. & Systems 2023-10-31 Mostafa Jahanifar , Manahil Raza , Kesi Xu , Trinh Vuong , Rob Jewsbury , Adam Shephard , Neda Zamanitajeddin , Jin Tae Kwak , Shan E Ahmed Raza , Fayyaz Minhas , Nasir Rajpoot

When machine learning models are deployed on a test distribution different from the training distribution, they can perform poorly, but overestimate their performance. In this work, we aim to better estimate a model's performance under…

Machine Learning · Computer Science 2020-07-08 Ching-Yao Chuang , Antonio Torralba , Stefanie Jegelka

We provide in this paper a comprehensive comparison of various transfer learning strategies and deep learning architectures for computer-aided classification of adult-type diffuse gliomas. We evaluate the generalizability of out-of-domain…

Histopathology slide digitization introduces scanner-induced domain shift that can significantly impact computational pathology models based on deep learning methods. In the state-of-the-art, this shift is often characterized at a broad…

Domain shifts in the training data are common in practical applications of machine learning; they occur for instance when the data is coming from different sources. Ideally, a ML model should work well independently of these shifts, for…

Histopathology relies on the analysis of microscopic tissue images to diagnose disease. A crucial part of tissue preparation is staining whereby a dye is used to make the salient tissue components more distinguishable. However, differences…

Image and Video Processing · Electrical Eng. & Systems 2022-08-03 Haseeb Nazki , Ognjen Arandjelović , InHwa Um , David Harrison

Magnetic Resonance Imaging (MRI) is widely used in routine clinical diagnosis and treatment. However, variations in MRI acquisition protocols result in different appearances of normal and diseased tissue in the images. Convolutional neural…

With promising results of machine learning based models in computer vision, applications on medical imaging data have been increasing exponentially. However, generalizations to complex real-world clinical data is a persistent problem. Deep…

Computer Vision and Pattern Recognition · Computer Science 2020-07-27 Nooshin Mojab , Vahid Noroozi , Darvin Yi , Manoj Prabhakar Nallabothula , Abdullah Aleem , Phillip S. Yu , Joelle A. Hallak

In histopathology, scanner-induced domain shifts are known to impede the performance of trained neural networks when tested on unseen data. Multi-domain pre-training or dedicated domain-generalization techniques can help to develop…

Automated detection of mitotic figures in histopathology images has seen vast improvements, thanks to modern deep learning-based pipelines. Application of these methods, however, is in practice limited by strong variability of images…

Computer Vision and Pattern Recognition · Computer Science 2021-03-31 Marc Aubreville , Christof Bertram , Mitko Veta , Robert Klopfleisch , Nikolas Stathonikos , Katharina Breininger , Natalie ter Hoeve , Francesco Ciompi , Andreas Maier

Deep learning has revolutionized neuroimage analysis by delivering unprecedented speed and accuracy. However, the narrow scope of many training datasets constrains model robustness and generalizability. This challenge is particularly acute…

Image and Video Processing · Electrical Eng. & Systems 2025-12-08 Malte Hoffmann

Classical Domain Adaptation methods acquire transferability by regularizing the overall distributional discrepancies between features in the source domain (labeled) and features in the target domain (unlabeled). They often do not…

Machine Learning · Computer Science 2023-06-01 Shumin Ma , Zhiri Yuan , Qi Wu , Yiyan Huang , Xixu Hu , Cheuk Hang Leung , Dongdong Wang , Zhixiang Huang

Clinical data is often affected by clinically irrelevant factors such as discrepancies between measurement devices or differing processing methods between sites. In the field of machine learning (ML), these factors are known as domains and…

In recent years, deep neural networks (DNNs) have demonstrated remarkable performance in pathology applications, potentially even outperforming expert pathologists due to their ability to learn subtle features from large datasets. One…

Image and Video Processing · Electrical Eng. & Systems 2024-09-16 Siyu , Lin , Haowen Zhou , Richard J. Cote , Mark Watson , Ramaswamy Govindan , Changhuei Yang

Images seen during test time are often not from the same distribution as images used for learning. This problem, known as domain shift, occurs when training classifiers from object-centric internet image databases and trying to apply them…

Computer Vision and Pattern Recognition · Computer Science 2013-08-21 Erik Rodner , Judy Hoffman , Jeff Donahue , Trevor Darrell , Kate Saenko

Histopathology is a reflection of the molecular changes and provides prognostic phenotypes representing the disease progression. In this study, we introduced feature scores generated from hematoxylin and eosin histology images based on deep…

Quantitative Methods · Quantitative Biology 2020-07-28 Okyaz Eminaga , Mahmood Abbas , Yuri Tolkach , Rosalie Nolley , Christian Kunder , Axel Semjonow , Martin Boegemann

Medical Image Analysis (MedIA) has emerged as a crucial tool in computer-aided diagnosis systems, particularly with the advancement of deep learning (DL) in recent years. However, well-trained deep models often experience significant…

Computer Vision and Pattern Recognition · Computer Science 2024-02-14 Ziwei Niu , Shuyi Ouyang , Shiao Xie , Yen-wei Chen , Lanfen Lin

Recognition across domains has recently become an active topic in the research community. However, it has been largely overlooked in the problem of recognition in new unseen domains. Under this condition, the delivered deep network models…

Computer Vision and Pattern Recognition · Computer Science 2020-04-15 Thanh-Dat Truong , Chi Nhan Duong , Khoa Luu , Minh-Triet Tran , Ngan Le

The hypothesis that computational models can be reliable enough to be adopted in prognosis and patient care is revolutionizing healthcare. Deep learning, in particular, has been a game changer in building predictive models, thus leading to…

Machine Learning · Statistics 2019-06-17 Jayaraman J. Thiagarajan , Deepta Rajan , Prasanna Sattigeri

Classical machine learning assumes that the training and test sets come from the same distributions. Therefore, a model learned from the labeled training data is expected to perform well on the test data. However, This assumption may not…

Machine Learning · Computer Science 2020-10-12 Abolfazl Farahani , Sahar Voghoei , Khaled Rasheed , Hamid R. Arabnia