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Domain shift in the field of histopathological imaging is a common phenomenon due to the intra- and inter-hospital variability of staining and digitization protocols. The implementation of robust models, capable of creating generalized…

Computer Vision and Pattern Recognition · Computer Science 2024-12-06 Ilán Carretero , Pablo Meseguer , Rocío del Amor , Valery Naranjo

Domain shift in digital histopathology can occur when different stains or scanners are used, during stain translation, etc. A deep neural network trained on source data may not generalise well to data that has undergone some domain shift.…

Image and Video Processing · Electrical Eng. & Systems 2022-05-10 Zeeshan Nisar , Jelica Vasiljević , Pierre Gançarski , Thomas Lampert

In AI-based histopathology, domain shifts are common and well-studied. However, this research focuses on stain and scanner variations, which do not show the full picture -- shifts may be combinations of other shifts, or "invisible" shifts…

Image and Video Processing · Electrical Eng. & Systems 2023-05-10 Andrew Walker

While deep learning models become more widespread, their ability to handle unseen data and generalize for any scenario is yet to be challenged. In medical imaging, there is a high heterogeneity of distributions among images based on the…

Image and Video Processing · Electrical Eng. & Systems 2025-05-01 Eduardo H. P. Pooch , Pedro L. Ballester , Rodrigo C. Barros

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

As many algorithms depend on a suitable representation of data, learning unique features is considered a crucial task. Although supervised techniques using deep neural networks have boosted the performance of representation learning, the…

Computer Vision and Pattern Recognition · Computer Science 2020-09-07 Milad Sikaroudi , Amir Safarpoor , Benyamin Ghojogh , Sobhan Shafiei , Mark Crowley , H. R. Tizhoosh

Whole Slide Images (WSIs) in digital pathology are used to diagnose cancer subtypes. The difference in procedures to acquire WSIs at various trial sites gives rise to variability in the histopathology images, thus making consistent…

Image and Video Processing · Electrical Eng. & Systems 2022-04-07 Milad Sikaroudi , Shahryar Rahnamayan , H. R. Tizhoosh

The well known domain shift issue causes model performance to degrade when deployed to a new target domain with different statistics to training. Domain adaptation techniques alleviate this, but need some instances from the target domain to…

Machine Learning · Computer Science 2019-06-11 Yiying Li , Yongxin Yang , Wei Zhou , Timothy M. Hospedales

The limited ability of Convolutional Neural Networks to generalize to images from previously unseen domains is a major limitation, in particular, for safety-critical clinical tasks such as dermoscopic skin cancer classification. In order to…

Computer Vision and Pattern Recognition · Computer Science 2023-07-04 Katharina Fogelberg , Sireesha Chamarthi , Roman C. Maron , Julia Niebling , Titus J. Brinker

In real-life applications, machine learning models often face scenarios where there is a change in data distribution between training and test domains. When the aim is to make predictions on distributions different from those seen at…

Machine Learning · Computer Science 2021-11-04 Lucas Mansilla , Rodrigo Echeveste , Diego H. Milone , Enzo Ferrante

Deep learning-based methods deliver state-of-the-art performance for solving inverse problems that arise in computational imaging. These methods can be broadly divided into two groups: (1) learn a network to map measurements to the signal…

Image and Video Processing · Electrical Eng. & Systems 2023-10-11 Nebiyou Yismaw , Ulugbek S. Kamilov , M. Salman Asif

Histopathology is critical for the diagnosis of many diseases, including cancer. These protocols typically require pathologists to manually evaluate slides under a microscope, which is time-consuming and subjective, leading to interest in…

Computer Vision and Pattern Recognition · Computer Science 2023-03-07 Kianoush Falahkheirkhah , Alex Lu , David Alvarez-Melis , Grace Huynh

Machine learning techniques used in computer-aided medical image analysis usually suffer from the domain shift problem caused by different distributions between source/reference data and target data. As a promising solution, domain…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Hao Guan , Mingxia Liu

Purpose: Medical images acquired using different scanners and protocols can differ substantially in their appearance. This phenomenon, scanner domain shift, can result in a drop in the performance of deep neural networks which are trained…

Image and Video Processing · Electrical Eng. & Systems 2024-10-03 Brian Guo , Darui Lu , Gregory Szumel , Rongze Gui , Tingyu Wang , Nicholas Konz , Maciej A. Mazurowski

Model generalization capacity at domain shift (e.g., various imaging protocols and scanners) is crucial for deep learning methods in real-world clinical deployment. This paper tackles the challenging problem of domain generalization, i.e.,…

Computer Vision and Pattern Recognition · Computer Science 2020-07-07 Quande Liu , Qi Dou , Pheng-Ann Heng

Supervised deep learning models often achieve excellent performance within their training distribution but struggle to generalize beyond it. In cancer histopathology, for example, a convolutional neural network (CNN) may classify cancer…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Justin Cheung , Samuel Savine , Calvin Nguyen , Lin Lu , Alhassan S. Yasin

Preparing and scanning histopathology slides consists of several steps, each with a multitude of parameters. The parameters can vary between pathology labs and within the same lab over time, resulting in significant variability of the…

Computer Vision and Pattern Recognition · Computer Science 2018-01-11 Maxime W. Lafarge , Josien P. W. Pluim , Koen A. J. Eppenhof , Pim Moeskops , Mitko Veta

While machine learning is currently transforming the field of histopathology, the domain lacks a comprehensive evaluation of state-of-the-art models based on essential but complementary quality requirements beyond a mere classification…

Image and Video Processing · Electrical Eng. & Systems 2023-05-11 Maximilian Springenberg , Annika Frommholz , Markus Wenzel , Eva Weicken , Jackie Ma , Nils Strodthoff

Numerous Deep Learning (DL) classification models have been developed for a large spectrum of medical image analysis applications, which promises to reshape various facets of medical practice. Despite early advances in DL model validation…

Image and Video Processing · Electrical Eng. & Systems 2024-10-22 Sarah Matta , Mathieu Lamard , Philippe Zhang , Alexandre Le Guilcher , Laurent Borderie , Béatrice Cochener , Gwenolé Quellec

Recent advances in deep learning for medical image segmentation demonstrate expert-level accuracy. However, in clinically realistic environments, such methods have marginal performance due to differences in image domains, including…

Computer Vision and Pattern Recognition · Computer Science 2019-06-13 Ling Zhang , Xiaosong Wang , Dong Yang , Thomas Sanford , Stephanie Harmon , Baris Turkbey , Holger Roth , Andriy Myronenko , Daguang Xu , Ziyue Xu
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