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Linear mixed models (LMMs), which incorporate fixed and random effects, are key tools for analyzing heterogeneous data, such as in personalized medicine. Nowadays, this type of data is increasingly wide, sometimes containing thousands of…

Machine Learning · Statistics 2026-05-15 Ryan Thompson , Matt P. Wand , Joanna J. J. Wang

The mixed effects model for repeated measures (MMRM) has been widely used for the analysis of longitudinal clinical data collected at a number of fixed time points. We propose a robust extension of the MMRM for skewed and heavy-tailed data…

Methodology · Statistics 2019-08-12 Yongqiang Tang

Estimating treatment effects using observation data often relies on the assumption of no unmeasured confounders. However, unmeasured confounding variables may exist in many real-world problems. It can lead to a biased estimation without…

Methodology · Statistics 2024-11-19 Namhwa Lee , Shujie Ma

Standard random-effects meta-analysis relies heavily on the assumption that the underlying true effects are normally distributed. In the social sciences, where evidence synthesis increasingly involves large, highly heterogeneous datasets,…

Methodology · Statistics 2026-05-01 Daihe Sui , Elizabeth Tipton

Mixed linear models are commonly used in repeated measures studies. They account for the dependence amongst observations obtained from the same experimental unit. Oftentimes, the number of observations is small, and it is thus important to…

Methodology · Statistics 2011-08-05 Tatiane F. N. Melo , Silvia L. P. Ferrari , Francisco Cribari-Neto

Fixed effects models are very flexible because they do not make assumptions on the distribution of effects and can also be used if the heterogeneity component is correlated with explanatory variables. A disadvantage is the large number of…

Methodology · Statistics 2015-12-17 Moritz Berger , Gerhard Tutz

General log-linear models specified by non-negative integer design matrices have a potentially wide range of applications, although using models without the genuine overall effect, that is, ones which cannot be reparameterized to include a…

Methodology · Statistics 2023-01-02 Anna Klimova , Matthias Kuhn

The ensemble empirical mode decomposition (EEMD) and its complete variant (CEEMDAN) are adaptive, noise-assisted data analysis methods that improve on the ordinary empirical mode decomposition (EMD). All these methods decompose possibly…

Computation · Statistics 2017-07-04 P. J. J. Luukko , J. Helske , E. Räsänen

This paper addresses challenges in flexibly modeling multimodal data that lie on constrained spaces. Such data are commonly found in spatial applications, such as climatology and criminology, where measurements are restricted to a…

Computation · Statistics 2019-12-03 Putu Ayu Sudyanti , Vinayak Rao

We study the problem of learning a mixture of multiple linear dynamical systems (LDSs) from unlabeled short sample trajectories, each generated by one of the LDS models. Despite the wide applicability of mixture models for time-series data,…

Machine Learning · Statistics 2022-05-26 Yanxi Chen , H. Vincent Poor

The analysis of experimental data with mixed-effects models requires decisions about the specification of the appropriate random-effects structure. Recently, Barr, Levy, Scheepers, and Tily, 2013 recommended fitting `maximal' models with…

Methodology · Statistics 2018-05-29 Douglas Bates , Reinhold Kliegl , Shravan Vasishth , Harald Baayen

Exponential tilting is a technique commonly used in fields such as statistics, probability, information theory, and optimization to create parametric distribution shifts. Despite its prevalence in related fields, tilting has not seen…

Machine Learning · Computer Science 2023-06-02 Tian Li , Ahmad Beirami , Maziar Sanjabi , Virginia Smith

Recent works have shown an interest in investigating the frequentist asymptotic properties of Bayesian procedures for high-dimensional linear models under sparsity constraints. However, there exists a gap in the literature regarding…

Statistics Theory · Mathematics 2025-09-23 Marion Naveau , Maud Delattre , Laure Sansonnet

Item response theory (IRT) models typically rely on a normality assumption for subject-specific latent traits, which is often unrealistic in practice. Semiparametric extensions based on Dirichlet process mixtures offer a more flexible…

The adaptive asymmetric trimmed mean is a known way of estimating central location, usually in conjunction with the bootstrap. It is here modified and applied to meta-analysis, as a way of dealing with outlying results by down-weighting the…

Applications · Statistics 2019-07-17 Rose Baker

Online controlled experiments face growing challenges from overlapping tests on shared traffic, where interactions between concurrent experiments obscure insights into feature combinations and produce effect estimates that do not correspond…

Methodology · Statistics 2026-04-21 Reza Hosseini

Longitudinal targeted maximum likelihood estimation (LTMLE) has very rarely been used to estimate dynamic treatment effects in the context of time-dependent confounding affected by prior treatment when faced with long follow-up times,…

A mixed data frame (MDF) is a table collecting categorical, numerical and count observations. The use of MDF is widespread in statistics and the applications are numerous from abundance data in ecology to recommender systems. In many cases,…

Methodology · Statistics 2019-03-27 Geneviève Robin , Olga Klopp , Julie Josse , Éric Moulines , Robert Tibshirani

Linear mixed effects models are highly flexible in handling a broad range of data types and are therefore widely used in applications. A key part in the analysis of data is model selection, which often aims to choose a parsimonious model…

Methodology · Statistics 2013-06-12 Samuel Müller , J. L. Scealy , A. H. Welsh

Non-linear mixed effects modeling and simulation (NLME M&S) is evaluated to be used for standardization with longitudinal data in presence of confounders. Standardization is a well-known method in causal inference to correct for confounding…