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We investigate a class of diffusion-controlled reactions that are initiated at the time instance when a prescribed number $K$ among $N$ particles independently diffusing in a solvent are simultaneously bound to a target region. In the…

Chemical Physics · Physics 2023-10-17 Denis S. Grebenkov , Aanjaneya Kumar

The first-passage time (FPT), defined as the time a random walker takes to reach a target point in a confining domain, is a key quantity in the theory of stochastic processes. Its importance comes from its crucial role to quantify the…

Statistical Mechanics · Physics 2017-02-01 T. Guérin , N. Levernier , O. Bénichou , R. Voituriez

Continuous-time stochastic processes play an important role in the description of random phenomena, it is therefore of prime interest to study particular variables depending on their paths, like stopping time for example. One approach…

Probability · Mathematics 2023-01-09 Samuel Herrmann , Nicolas Massin

The Ornstein-Uhlenbeck process of diffusion in the harmonic potential is re-examined in the context of the first-passage time problem. We investigate this problem to the extent that it has not yet been fully resolved and demonstrate exact…

General Physics · Physics 2025-07-10 Przemyslaw Chelminiak

Diffusion of molecules within biological cells and tissues is strongly influenced by crowding. A key quantity to characterize diffusion is the particle lifetime, which is the time taken for a diffusing particle to exit by hitting an…

Biological Physics · Physics 2018-04-03 Elliot J Carr , Matthew J Simpson

The study of first passage times for diffusing particles reaching target states is foundational in various practical applications, including diffusion-controlled reactions. In this work, we present a bi-scaling theory for the probability…

Statistical Mechanics · Physics 2025-03-21 Talia Baravi , David A. Kessler , Eli Barkai

The problem of the time required for a diffusing molecule, within a large bounded domain, to first locate a small target is prevalent in biological modeling. Here we study this problem for a small spherical target. We develop uniform in…

Biological Physics · Physics 2013-08-06 Samuel A. Isaacson , Jay Newby

Cover times measure the speed of exhaustive searches which require the exploration of an entire spatial region(s). Applications include the immune system hunting pathogens, animals collecting food, robotic demining or cleaning, and computer…

Probability · Mathematics 2024-07-11 Hyunjoong Kim , Sean D Lawley

The search for hidden targets is a fundamental problem in many areas of science, engineering, and other fields. Studies of search processes often adopt a probabilistic framework, in which a searcher randomly explores a spatial domain for a…

Probability · Mathematics 2021-03-16 Sean D Lawley

We derive expressions for the first three moments of the decision time (DT) distribution produced via first threshold crossings by sample paths of a drift-diffusion equation. The "pure" and "extended" diffusion processes are widely used to…

Neurons and Cognition · Quantitative Biology 2016-01-26 Vaibhav Srivastava , Philip Holmes , Patrick Simen

A schematic model of over-damped motion is presented which permits one to calculate the mean first passage time for nuclear fission. Its asymptotic value may exceed considerably the lifetime suggested by Kramers rate formula, which applies…

Nuclear Theory · Physics 2009-11-10 H. Hofmann , A. G. Magner

In this paper, we study a simple model of a diffusive particle on a line, undergoing a stochastic resetting with rate $r$, via rescaling its current position by a factor $a$, which can be either positive or negative. For $|a|<1$, the…

Statistical Mechanics · Physics 2024-11-08 Marco Biroli , Yannick Feld , Alexander K. Hartmann , Satya N. Majumdar , Gregory Schehr

We present exact results for the spectrum of the fractional Laplacian in a bounded domain and apply them to First Passage Time (FPT) Statistics of L\'evy flights. We specifically show that the average is insufficient to describe the…

Statistical Mechanics · Physics 2008-07-18 E. Katzav , M. Adda-Bedia

Many problems in finance require the information on the first passage time (FPT) of a stochastic process. Mathematically, such problems are often reduced to the evaluation of the probability density of the time for such a process to cross a…

Computational Engineering, Finance, and Science · Computer Science 2025-10-20 Di Zhang , Roderick V. N. Melnik

In the scenario of the narrow escape problem (NEP) a particle diffuses in a finite container and eventually leaves it through a small "escape window" in the otherwise impermeable boundary, once it arrives to this window and over-passes an…

Statistical Mechanics · Physics 2020-01-03 D. S. Grebenkov , R. Metzler , G. Oshanin

We correct a previously erroneous calculation [Phys. Rev. E 62, 6065 (2000)] of the mean first passage time of a subdiffusive process to reach either end of a finite interval in one dimension. The mean first passage time is in fact…

Statistical Mechanics · Physics 2007-05-23 S. B. Yuste , Katja Lindenberg

We study the time until first occurrence, the first-passage time, of rare density fluctuations in diffusive systems. We approach the problem using a model consisting of many independent random walkers on a lattice. The existence of spatial…

Statistical Mechanics · Physics 2008-05-16 David P. Sanders , Hernán Larralde

We study a one-dimensional run-and-tumble particle (RTP), which is a prototypical model for active system, moving within an arbitrary external potential. Using backward Fokker-Planck equations, we derive the differential equation satisfied…

Statistical Mechanics · Physics 2025-01-27 Mathis Guéneau , Satya N. Majumdar , Gregory Schehr

Random search for one or more targets in a bounded domain occurs widely in nature, with examples ranging from animal foraging to the transport of vesicles within cells. Most theoretical studies take a searcher-centric viewpoint, focusing on…

Statistical Mechanics · Physics 2021-01-13 Paul C Bressloff

For transport processes in geometrically restricted domains, the mean first-passage time (MFPT) admits a general scaling dependence on space parameters for diffusion, anomalous diffusion, and diffusion in disordered or fractal media. For…

Statistical Mechanics · Physics 2015-06-05 Eric Akkermans , Olivier Benichou , Gerald Dunne , Alexander Teplyaev , Raphael Voituriez
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